Self-Management Systems for Patients and Clinicians in Parkinson’s Disease Care: A Scoping Review DOI Creative Commons

Selina Boege,

Madison Milne‐Ives, Ananya Ananthakrishnan

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(7), P. 1387 - 1404

Published: Oct. 11, 2024

Digital self-management tools including mobile apps and wearables can enhance personalized care in Parkinson's disease, incorporating patient clinician feedback into their evaluation empower users nurture patient-clinician relationships, necessitating a review to assess the state of art refine use.

Language: Английский

Cell therapy for neurological disorders DOI

Soshana Svendsen,

Clive N. Svendsen

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(10), P. 2756 - 2770

Published: Oct. 1, 2024

Language: Английский

Citations

9
Biological definitions of synucleinopathies should be anchored in clinical trajectories and encompass the complex biology of the disease DOI Creative Commons
David Bendetowicz, Vincent Planche, Erwan Bézard

et al.

Journal of Parkinson s Disease, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Recently, two proposals for defining Parkinson's disease and its related pathogenic processes have been published. In this viewpoint, we discuss the primary drivers behind these efforts, future directions, challenges that must be addressed. While finding biomarkers is a mandatory step better precision medicine optimal patient stratification in therapeutic trials, argue biological definition of based on single biomarker will struggle to account complexity mechanisms involved developing disease. Additionally, asymptomatic patients should rely thorough understanding patients’ clinical trajectories, which currently not case synucleinopathies.

Language: Английский

Citations

0
Biological frameworks for Parkinson’s disease: the heterogeneity SAAgged DOI
Annamaria Landolfi, Cristiano Sorrentino, Paolo Barone

et al.

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: April 1, 2025

Language: Английский

Citations

0
Abundant non-inclusion α-synuclein pathology in Lewy body-negative LRRK2-mutant cases DOI Creative Commons
Nanna Møller Jensen, Zagorka Vitic,

Mia R. Antorini

et al.

Acta Neuropathologica, Journal Year: 2025, Volume and Issue: 149(1)

Published: May 2, 2025

Abstract Lewy body diseases are common neurodegenerative diseases, including Parkinson’s disease (PD) and dementia with bodies, which lead to both motor non-motor symptoms. They neuropathologically characterized by loss of neuromelanized neurons in the substantia nigra pars compacta α-synuclein-immunopositive inclusions (Lewy bodies) several types brain. A fraction monogenic PD cases, however, represent a conundrum, as they can present clinical but do not have bodies upon neuropathological examination. For LRRK2, presence or absence is related any specific mutation gene different presentation neuropathology be even same family. Here, we first evidence widespread α-synuclein accumulation detected proximity ligation assay (PLA) using MJFR14-6-4-2 antibody six body-negative LRRK2 cases compare levels five patients verified healthy controls. We show that non-inclusion aggregated form particulate PLA signal dominant while Lewy-like found late-stage disease. Furthermore, displayed prominent pontocerebellar tracts inferior olivary nuclei brainstem, was seen idiopathic cases. These results suggest Lewy-body negative LRRK2-related associated lack aggregation rather deficiency formation inclusions.

Language: Английский

Citations

0
Clinicians’ viewpoints on current paradigms of care and research in Parkinson’s disease DOI
Thomas Müller, Carsten Buhmann,

Martin Delf

et al.

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(12), P. 1455 - 1462

Published: Aug. 19, 2024

Language: Английский

Citations

0
Self-Management Systems for Patients and Clinicians in Parkinson’s Disease Care: A Scoping Review DOI Creative Commons

Selina Boege,

Madison Milne‐Ives, Ananya Ananthakrishnan

et al.

Journal of Parkinson s Disease, Journal Year: 2024, Volume and Issue: 14(7), P. 1387 - 1404

Published: Oct. 11, 2024

Digital self-management tools including mobile apps and wearables can enhance personalized care in Parkinson's disease, incorporating patient clinician feedback into their evaluation empower users nurture patient-clinician relationships, necessitating a review to assess the state of art refine use.

Language: Английский

Citations

0