Balancing Hope and Harm: A Qualitative Exploration of Ethical Aspects of using AI in Parkinson’s Disease (Preprint) DOI
Jamie Linnéa Luckhaus, Therese Scott Duncan, Anna Kharko

et al.

Published: March 20, 2025

BACKGROUND As Parkinson’s disease (PD) rates increase, so does interest in finding new technological solutions for PD management. Despite substantial efforts to explore potential applications of AI management, research from people with (PwP)’s perspectives on remains limited. OBJECTIVE To ethical considerations management a PwP perspective. METHODS A qualitative triangulation 13 interviews and two focus groups an expert panel six European countries was carried out using abductive thematic analysis. The biomedical principles conceptualized by Beauchamp Childress guided the Participants varied diagnosis, experiences backgrounds. researcher involved start finish, providing valuable insights data collection RESULTS While optimistic that could enhance autonomy beneficence through personalized, actionable their healthcare professionals, concerns arose over patient involvement, model accuracy privacy, injustices, psychological impact. Risk prediction, prognosis, medication response were viewed differently terms value considerations, risk prediction being perceived as most ethically complex. uphold autonomy, it considered important be patient-accessible, sensitive should communicated professional who recognizes individual differences desiring responding predictions. CONCLUSIONS felt personalize (self-)care increase harm widening inequalities highlight importance safeguards. Our findings underscore integrations prioritize needs, actively involving development, implementation, interpretation predictive AI, guidelines assist professionals avoid harm. Different forms implementation precautions taken risk, progression, prediction.

Language: Английский

The neurotoxicity of pesticides: Implications for Parkinson's disease DOI Creative Commons
Leslie Amaral,

Mário Martins,

Manuela Côrte‐Real

et al.

Chemosphere, Journal Year: 2025, Volume and Issue: 377, P. 144348 - 144348

Published: April 9, 2025

Parkinson's disease (PD) is the fastest-growing neurodegenerative disorder worldwide, and no effective cure currently available. Neuropathologically, PD characterized by selective degeneration of dopaminergic neurons in substantia nigra accumulation alpha-synuclein (aSyn)-rich proteinaceous inclusions within surviving neurons. As a multifactorial disorder, approximately 85 % cases are sporadic with unknown etiology. Among many risk factors implicated PD, exposure to neurotoxic pesticides stands out as significant contributor. While effects still uncharacterized, it has already been shown that rotenone, paraquat, maneb, dieldrin affect critical cellular pathways, including mitochondrial proteasomal dysfunction, aSyn aggregation, autophagy dysregulation, disruption dopamine metabolism. With constant rise pesticide usage meet demands growing human population, environmental contamination subsequent development also increasing. This review explores molecular mechanisms which influences development, shedding light on their role pathogenesis highlighting need for preventative measures regulatory oversight mitigate these risks.

Language: Английский

Citations

0
Optical coherence tomography reveals retinal structural abnormalities in α-synucleinopathies: insights from the Padua-CESNE cohort DOI Creative Commons
Marta Campagnolo, Marco Puthenparampil, Aron Emmi

et al.

Journal of Neural Transmission, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Language: Английский

Citations

0
Balancing Hope and Harm: A Qualitative Exploration of Ethical Aspects of using AI in Parkinson’s Disease (Preprint) DOI
Jamie Linnéa Luckhaus, Therese Scott Duncan, Anna Kharko

et al.

Published: March 20, 2025

BACKGROUND As Parkinson’s disease (PD) rates increase, so does interest in finding new technological solutions for PD management. Despite substantial efforts to explore potential applications of AI management, research from people with (PwP)’s perspectives on remains limited. OBJECTIVE To ethical considerations management a PwP perspective. METHODS A qualitative triangulation 13 interviews and two focus groups an expert panel six European countries was carried out using abductive thematic analysis. The biomedical principles conceptualized by Beauchamp Childress guided the Participants varied diagnosis, experiences backgrounds. researcher involved start finish, providing valuable insights data collection RESULTS While optimistic that could enhance autonomy beneficence through personalized, actionable their healthcare professionals, concerns arose over patient involvement, model accuracy privacy, injustices, psychological impact. Risk prediction, prognosis, medication response were viewed differently terms value considerations, risk prediction being perceived as most ethically complex. uphold autonomy, it considered important be patient-accessible, sensitive should communicated professional who recognizes individual differences desiring responding predictions. CONCLUSIONS felt personalize (self-)care increase harm widening inequalities highlight importance safeguards. Our findings underscore integrations prioritize needs, actively involving development, implementation, interpretation predictive AI, guidelines assist professionals avoid harm. Different forms implementation precautions taken risk, progression, prediction.

Language: Английский

Citations

0