medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: June 29, 2023

Abstract Background Parkinson’s disease (PD) and Essential Tremor (ET) are heterogeneous, yet distinct disorders. At the same time, PD ET show overlapping features such as phenotypes with predominant tremor. These heterogeneities overlaps pose challenges for clinical management research may indicate transdiagnostic, shared mechanisms Objectives To test hypothesis that MRI reveal structural brain changes related to tremor rather than diagnoses in patients. For this, we compared regional volumes between three patient groups diagnoses: ET, tremor-dominant phenotype (PD-T), non-tremor-dominant (PD-nT). Methods We studied 164 patients (18 38 PD-T, 108 PD-nT) who were evaluated deep stimulation. All underwent MRI, standardized assessment of motor symptoms. groups. Results Volumes thalamus, pallidum, pre-cerebellar upper brainstem (midbrain, pons, superior cerebellar peduncle) differed across smallest intermediate largest PD-nT. Differences reached significance when comparing or PD-T PD-nT but not PD-T. Thalamic correlated more severe less levodopa-responsive PD. In contrast subcortical findings, cortical thickness frontal parietal regions was thinner Conclusions identified tremor-related volume loss cerebellothalamic interconnected (pallidum), potentially suggesting pointing towards a transdiagnostic signature

Language: Английский