Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies DOI Creative Commons
E. R. de Kloet

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2022, Volume and Issue: 24, P. 100352 - 100352

Published: April 13, 2022

Cortisol and corticosterone (CORT) coordinate circadian events manage the stress response by differential activation of two complementary brain receptor systems, i.e., mineralocorticoid (MR) glucocorticoid (GR), which mediate rapid non-genomic slow genomic actions. Several recent discoveries are highlighted from molecular fine-tuning MR/GR balance FKBP5 to CORTs role in neural network regulation underlying adaptation emotional, cognitive, social domains behavior. The data suggest that MR mediates CORT action on risk assessment, interaction, selection, while GR promotes memory consolidation behavioral adaptation; there also sex differences action. New evidence suggests targeting resets a dysregulated system resilience.

Language: Английский

Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy DOI Creative Commons
Yang Xu, YangQuan Chen,

Jia‐xin Xing

et al.

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: Jan. 24, 2025

Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on biological functions associated with NDs, emphasizing role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed molecular underpinnings effects EE, including modulation key signaling pathways such extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), AMPK/SIRT1, which were implicated neuroprotection synaptic plasticity. Additionally, we scrutinized influence epigenetic modifications autophagy, processes pivotal ND pathogenesis. Animal models, encompassing both rodents larger animals, offer insights into disease-modifying underscoring complementary approach pharmacological interventions. In summary, emerges promising strategy augment function decelerate progression NDs.

Language: Английский

Citations

1
The relative benefits of environmental enrichment on learning and memory are greater when stressed: A meta-analysis of interactions in rodents DOI
Erin L. Macartney, Malgorzata Lagisz, Shinichi Nakagawa

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 135, P. 104554 - 104554

Published: Feb. 8, 2022

Language: Английский

Citations

34
Environmental Enrichment and Epigenetic Changes in the Brain: From the Outside to the Deep Inside DOI
Rodrigo F. Torres, Nuria Llontop, Cristian Espinoza

et al.

Sub-cellular biochemistry/Subcellular biochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 217 - 230

Published: Jan. 1, 2025

Language: Английский

Citations

0
Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes DOI Creative Commons

Mark Wulczynski,

Stephen P. J. Brooks,

Judy Green

et al.

Animal Microbiome, Journal Year: 2025, Volume and Issue: 7(1)

Published: Jan. 31, 2025

Environmental enrichment (EE) is commonly included as an important component of animal housing to promote well being laboratory animals; however, much remains be learned about the impact chewable forms EE on experimental outcomes in context nutritional and microbiome-related studies, whether differ between sexes. In present study, nylon chew bones (gnaw sticks, GS) were evaluated for their effects fermentation profiles, microbial community structure, cytokine profiles gastrointestinal systemic tissues pair-housed female male Sprague Dawley (SD) rats. Food consumption weight gain not significantly altered by access GS. Cecal short-chain fatty acid branched-chain differed sexes rats with GS, alpha diversity microbiome decreased females provided Sex-related tissue also without These findings indicate that including GS can influence microbiota immune-related parameters, a sex dependent manner. This shows environmental strategies need clearly reported publications properly evaluate compare results, especially respect use studies examining diet, immune parameters.

Language: Английский

Citations

0
The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle DOI
Mijail Rojas‐Carvajal,

Andrey Sequeira‐Cordero,

Juan C. Brenes

et al.

European Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 55(9-10), P. 2359 - 2392

Published: Feb. 27, 2021

Mounting evidence shows that physical activity, social interaction and sensorimotor stimulation provided by environmental enrichment (EE) exert several neurobehavioural effects traditionally interpreted as enhancements relative to standard housing (SH) conditions. However, this rather indicates SH induces many deficits, which could be ameliorated exposing animals an environment vaguely mimicking some features of their wild habitat. Rearing rodents in isolation (SI) can aggravate such restored or EE. It is not surprising, therefore, most preclinical stress models have included severe unnatural stressors produce a response prominent enough distinguishable from SI-frequently used control groups. Although current induce stress-related phenotype, they may fail represent the our urban lifestyle characterized SI, poor working environments, sedentarism, obesity limited access recreational activities exercise. In following review, we discuss living areas how exposures performing green environments are relievers. Based on commonalities between human animal EE, conditions (e.g., SI-SH-EE) adapted study modern lifestyle. The model might easy implement replicate leading more translational results. also contribute accomplishing ethical commitments promoting refinement procedures stress, diminishing suffering, enhancing welfare eventually reducing number experimental needed.

Language: Английский

Citations

30
Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression- and anxiety-like behavior, but have differential effects on amygdala gene expression DOI Creative Commons
Zachary A. Cordner, Isaiah Marshall-Thomas, Gretha J. Boersma

et al.

Neurobiology of Stress, Journal Year: 2021, Volume and Issue: 15, P. 100392 - 100392

Published: Sept. 11, 2021

The adverse effects of stress on brain and behavior have long been known well-studied, with abundant evidence linking to, among other things, mood anxiety disorders. Likewise, many investigated potential treatments for stress-related phenotypes demonstrated good response to standard antidepressant medications like selective serotonin reuptake inhibitors (SSRIs), as well environmental manipulations exercise or enrichment. However, the extent which various act overlapping pathways in is less understood. Here, we used a widely studied social defeat paradigm induce robust depression- anxiety-like phenotype chronic corticosterone elevation that persisted at least 4 weeks wild type male mice. When mice were treated either SSRI fluoxetine an enriched environment, both led similar behavioral recovery from defeat. We then focused amygdala assessed defeat, fluoxetine, enrichment 168 genes broadly related synaptic plasticity oxidative stress. found 24 differentially expressed Interestingly, broad normalization stress-induced expression pattern while changes separate set genes. Together, this study provides additional insight into gene amygdala. findings also suggest that, subset assessed, strikingly divergent amygdala, despite leading outcomes.

Language: Английский

Citations

27
Environmental Enrichment in Stroke Research: an Update DOI

Laura Tartari Neves,

Lisiê Valéria Paz, Andréa Wieck

et al.

Translational Stroke Research, Journal Year: 2023, Volume and Issue: 15(2), P. 339 - 351

Published: Jan. 31, 2023

Language: Английский

Citations

11
Socioeconomic Disparities in Hypothalamic-Pituitary-Adrenal Axis Regulation and Prefrontal Cortical Structure DOI Creative Commons
Emily C. Merz, Brent Myers, Melissa Hansen

et al.

Biological Psychiatry Global Open Science, Journal Year: 2023, Volume and Issue: 4(1), P. 83 - 96

Published: Oct. 30, 2023

Socioeconomic disadvantage during childhood predicts an increased risk for mental health problems across the life span. shapes multiple aspects of children's proximal environments and increases exposure to chronic stressors. Drawing from literatures, we propose that socioeconomic may lead adaptive changes in regulation stress response systems including hypothalamic-pituitary-adrenal (HPA) axis. These changes, turn, affect development prefrontal cortical (PFC) circuitry responsible top-down control over cognitive emotional processes. Translational findings indicate reduces dendritic complexity spine density medial PFC anterior cingulate cortex, part through altered HPA axis regulation. has frequently been associated with reduced gray matter dorsolateral ventrolateral cortex lower fractional anisotropy superior longitudinal fasciculus, cingulum bundle, uncinate fasciculus middle adolescence. Evidence disparities hair cortisol concentrations children accumulated, although null have reported. Coupled links between levels these results support mechanistic roles circuits. Future studies should simultaneously consider dimensions factors, stimulation, while focusing on epigenetic processes genetic moderators elucidate how context influence involved control. findings, which point modifiable can be harnessed inform policy more effective prevention strategies.

Language: Английский

Citations

11
A novel probiotic formula, BLLL, ameliorates chronic stress-induced depression-like behaviors in mice by reducing neuroinflammation and increasing neurotrophic factors DOI Creative Commons

Minxiu Ye,

Feng Ji, Chao Huang

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 26, 2024

Probiotics have been recognized for their various biological activities, including antioxidant and anti-inflammatory properties. This study investigates the therapeutic effect of a novel probiotic formula, BLLL, consisting

Language: Английский

Citations

4
Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats. DOI
Jeffrey W. Grimm,

Frances Sauter,

Derek MacDougall

et al.

Physiology & Behavior, Journal Year: 2025, Volume and Issue: 291, P. 114810 - 114810

Published: Jan. 10, 2025

Language: Английский

Citations

0