Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies DOI Creative Commons
E. R. de Kloet

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2022, Volume and Issue: 24, P. 100352 - 100352

Published: April 13, 2022

Cortisol and corticosterone (CORT) coordinate circadian events manage the stress response by differential activation of two complementary brain receptor systems, i.e., mineralocorticoid (MR) glucocorticoid (GR), which mediate rapid non-genomic slow genomic actions. Several recent discoveries are highlighted from molecular fine-tuning MR/GR balance FKBP5 to CORTs role in neural network regulation underlying adaptation emotional, cognitive, social domains behavior. The data suggest that MR mediates CORT action on risk assessment, interaction, selection, while GR promotes memory consolidation behavioral adaptation; there also sex differences action. New evidence suggests targeting resets a dysregulated system resilience.

Language: Английский

Reduction of restricted repetitive behavior by environmental enrichment: Potential neurobiological mechanisms DOI
Anna L. Farmer, Mark H. Lewis

Neuroscience & Biobehavioral Reviews, Journal Year: 2023, Volume and Issue: 152, P. 105291 - 105291

Published: June 21, 2023

Language: Английский

Citations

7
Τhe neuroprotective role of environmental enrichment against behavioral, morphological, neuroendocrine and molecular changes following chronic unpredictable mild stress: A systematic review DOI Creative Commons
Εvgenia Dandi, Evangelia Spandou, Christina Dalla

et al.

European Journal of Neuroscience, Journal Year: 2023, Volume and Issue: 58(4), P. 3003 - 3025

Published: July 17, 2023

Abstract Environmental factors interact with biological and genetic influencing the development well‐being of an organism. The interest in better understanding role environment on behavior physiology led to animal models environmental manipulations. enrichment (EE), condition that allows cognitive sensory stimulation as well social interaction, improves function, reduces anxiety depressive‐like promotes neuroplasticity. In addition, it exerts protection against neurodegenerative disorders, aging deficits aggravated by stressful experiences. Given beneficial effects EE brain behavior, preclinical studies have focused its protective alternative, non‐invasive manipulation, help organism cope stress. A valid, reliable effective model chronic stress enhances depression‐like is unpredictable mild (CUMS). variety stressors unpredictability time sequence exposure prevent habituation, render CUMS ethologically relevant model. has been associated dysregulation hypothalamic–pituitary–adrenal axis, elevation basal levels hormones, reduction volume, dendritic atrophy alterations markers synaptic plasticity. Although numerous underlined compensatory negative various regimens (e.g. restraint isolation), research concerning interaction between sparse. purpose current systematic review present up‐to‐date findings regarding CUMS.

Language: Английский

Citations

7
The systemic effects of the enriched environment on the conditioned fear reaction DOI Creative Commons

Grigory Grigoryan

Frontiers in Behavioral Neuroscience, Journal Year: 2023, Volume and Issue: 17

Published: Aug. 22, 2023

In this review, a hypothesis is proposed to explain the beneficial effect of an enriched environment (EE) on conditioned fear reaction (CFR) from perspective functional system behavioral control. According hypothesis, EE affects all act components, including processing sensory information, memory, motivational and reinforcing systems, motor activities, which weakens CFR. Animals raised in have effects that are comparable those context (CTX) CS pre-exposures at latent inhibition. An abundance stimuli constant contact with them provide formation CS-noUS CTX-noUS connections later, during CFR learning, slow down diminish fear. The also contributes faster information habituation it. As result, many lose their significance, subjects simply ignore them. And finally, brain mechanisms, induces impairment search activity, worsens memory consolidation, leads reduction

Language: Английский

Citations

7
Different influences of anxiety models, environmental enrichment, standard conditions and intraspecies variation (sex, personality and strain) on stress and quality of life in adult and juvenile zebrafish: A systematic review DOI
Jhon Buenhombre, Erika Alexandra Daza-Cardona, Pêssi Socorro Lima de Sousa

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 131, P. 765 - 791

Published: Sept. 27, 2021

Language: Английский

Citations

16
Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies DOI Creative Commons
E. R. de Kloet

Current Opinion in Endocrine and Metabolic Research, Journal Year: 2022, Volume and Issue: 24, P. 100352 - 100352

Published: April 13, 2022

Cortisol and corticosterone (CORT) coordinate circadian events manage the stress response by differential activation of two complementary brain receptor systems, i.e., mineralocorticoid (MR) glucocorticoid (GR), which mediate rapid non-genomic slow genomic actions. Several recent discoveries are highlighted from molecular fine-tuning MR/GR balance FKBP5 to CORTs role in neural network regulation underlying adaptation emotional, cognitive, social domains behavior. The data suggest that MR mediates CORT action on risk assessment, interaction, selection, while GR promotes memory consolidation behavioral adaptation; there also sex differences action. New evidence suggests targeting resets a dysregulated system resilience.

Language: Английский

Citations

12