Sex differences in neuroimmunoendocrine communication. Involvement on longevity

Mechanisms of Ageing and Development, Journal Year: 2023, Volume and Issue: 211, P. 111798 - 111798

Published: March 11, 2023

Endocrine, nervous, and immune systems work coordinately to maintain the global homeostasis of organism. They show sex differences in their functions that, turn, contribute beyond reproductive function. Females display a better control energetic metabolism improved neuroprotection have more antioxidant defenses inflammatory status than males, which is associated with robust response that males. These are present from early stages life, being relevant adulthood influencing aging trajectory each may different life lifespan between sexes.

Language: Английский

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Enriched environment exposure during development positively impacts the structure and function of the visual cortex in mice

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: April 29, 2023

Optimal conditions of development have been interest for decades, since genetics alone cannot fully explain how an individual matures. In the present study, we used optical brain imaging to investigate whether a relatively simple enrichment can positively influence visual cortex mice. The paradigm was composed larger cages housing multiple mice that contained several toys, hiding places, nesting material and spinning wheel were moved or replaced at regular intervals. We compared C57BL/6N adult (> P60) had raised either in enriched environment (EE; n = 16) standard (ST; 12) from 1 week before birth adulthood, encompassing all cortical developmental stages. Here, report significant beneficial changes on structure function following environmental throughout lifespan. More specifically, retinotopic mapping through intrinsic signal revealed size primary greater reared EE controls. addition, field coverage wider. Finally, organization representation (as determined by magnification) versus its eccentricity also differed between two groups. did not observe any differences females males within each group. Taken together, these data demonstrate specific benefits cortex, which suggests adaptation their realities.

Language: Английский

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THE ROLE OF GENE-ENVIRONMENT INTERACTIONS IN SOCIAL DYSFUNCTION: FOCUS ON PRECLINICAL EVIDENCE FROM MOUSE STUDIES

Neuropharmacology, Journal Year: 2024, Volume and Issue: 261, P. 110179 - 110179

Published: Oct. 5, 2024

Language: Английский

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An early enriched experience drives targeted microglial engulfment of miswired neural circuitry during a restricted postnatal period

Glia, Journal Year: 2024, Volume and Issue: 72(7), P. 1217 - 1235

Published: March 21, 2024

Abstract Brain function is critically dependent on correct circuit assembly. Microglia are well‐known for their important roles in immunological defense and neural plasticity, but whether they can also mediate experience‐induced correction of miswired circuitry unclear. Ten‐m3 knockout (KO) mice display a pronounced stereotyped visuotopic mismapping ipsilateral retinal inputs visual thalamus, providing useful model to probe mechanisms. Environmental enrichment (EE) commenced around birth, not later life, drive partial the most mismapped KO mice. Here, we assess unlocks capacity microglia selectively engulf remove circuitry, timing this effect. Expression microglial‐associated lysosomal protein CD68 showed clear enrichment‐driven, spatially restricted change which had at postnatal day (P)18, was evident P21, more robust P25, ceased by P30. This observed specifically corrective pruning site absent control site. An engulfment assay P25 EE‐driven microglial‐uptake axon terminals. temporally specific, as no enrichment‐driven microglial seen P18 mice, nor locus. The timecourse determined anatomically, aligned with pattern reactivity engulfment. Collectively, these findings show experience targeted during window. may have therapeutic implications neurodevelopmental conditions involving aberrant connectivity.

Language: Английский

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Sex, Drugs, and TBI: The Effects of Sex Hormones and TrkB Activation on Alcohol-Related Behavior Following a Traumatic Brain Injury

Published: Jan. 1, 2024

Traumatic brain injury (TBI) and alcohol use disorder (AUD) exhibit a bidirectional relationship: AUD increases the risk of incurring TBI and, inversely, history future AUD. The second portion this relationship has not been as thoroughly investigated. Our lab previously demonstrated that juvenile significantly self-administration in females compared to uninjured injured developed conditioned place preference (CPP) for ethanol. Given stark sex difference, dissertation will examine mechanism through which occurred by investigating how manipulations steroids might affect result. We found ovariectomized were exposed testosterone perinatally did develop CPP Meanwhile, male mice gonadectomized at postnatal day (PND) 4 adulthood display any difference their alcohol-related behaviors. Additionally, we analyzed axonal degeneration investigate whether there was an effect hormone manipulation on severity, impact wherein increased. Still, no steroid manipulation. also saw have microglia number, indicating see behaviors is due changes severity. However, find increased males while females. These results indicate hormones are involved altered following early life. Previous work increase attenuated after they placed enriched environment (EE) immediately kept until adulthood. environmental enrichment traditionally shown neurogenesis brain-derived neurotrophic factor (BDNF) levels BDNF dysregulation associated with both pathology AUD, investigated different durations EE would alter expression genes related neuroplasticity context TBI. one week decreased these genes. five weeks neuroplasticity-related then asked 7,8-dihydroxyflavone, agonist tropomyosin receptor kinase (TrkB), activated BDNF, mimic effects self-administration. Interestingly, 7,8-DHF consumption but drinking animals. given compelling overlap TBI, posttraumatic stress (PTSD), employed elevated plus maze assess anxiety-related treatment, or treatment. examined differentially recovery although reduced degeneration, 7,8-DHF. Lastly, short-term treatment hippocampal neurogenesis. Importantly, amount newly formed cells hippocampus, suggesting could negatively when time point.

Language: Английский

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Restricted Daily Exposure of Environmental Enrichment: Bridging the Practical Gap from Animal Studies to Human Application

International Journal of Environmental Research and Public Health, Journal Year: 2024, Volume and Issue: 21(12), P. 1584 - 1584

Published: Nov. 27, 2024

Daily restricted environmental enrichment (REE) refers to limited, structured periods of aimed at improving both physical and cognitive well-being in animals humans. This review explores the significance REE, focusing on studies that investigate 2 3 h daily protocols. Through an analysis 21 key studies, this paper highlights how even brief REE can lead substantial improvements brain plasticity, function, stress resilience. The tracks evolution from early research enriched environments modern applications human rehabilitation, particularly for stroke recovery mental health treatment. While traditional approach often involves continuous exposure, recent suggests yield comparable benefits, offering a practical, scalable solution clinical settings. underscores importance adapting individual needs developing flexible, home-based programs broader application.

Language: Английский

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Psychopharmacology across the Lifespan

Pharmacology Biochemistry and Behavior, Journal Year: 2022, Volume and Issue: 222, P. 173494 - 173494

Published: Nov. 21, 2022

Language: Английский

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