Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice DOI Creative Commons

Mackenzie Newman,

Heather Connery,

Swapna Kannan

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 941 - 941

Published: July 14, 2024

Fentanyl overdose is a survivable condition that commonly resolves without chronic overt changes in phenotype. While the acute physiological effects of fentanyl overdose, such as opioid-induced respiratory depression (OIRD) and Wooden Chest Syndrome, represent immediate risks lethality, little known about longer-term systemic or organ-level impacts for survivors. In this study, we investigated single, bolus on components cardiopulmonary system up to one week post. SKH1 mice were administered subcutaneous at highest non-lethal dose (62 mg/kg), LD10 (110 LD50 (135 before euthanasia 40 min, 6 h, 24 7 d post-exposure. The cerebral cortex, heart, lungs, plasma assayed using an immune monitoring 48-plex panel. results showed significantly dysregulated cytokine, chemokine, growth factor concentrations compared time-matched controls, principally hearts, then lungs lesser extent, length with cortex largely unaffected. Major significant analytes contributing variance included eotaxin-1, IL-33, betacellulin, which generally downregulated across time. study suggest toxicity may persist from single have wide implications endurance expanding population

Language: Английский

Monoamine receptors targeted by methamphetamine differentially modulate basal and fentanyl-depressed respiration in mice DOI
Harrison Elder,

D. Matthew Walentiny,

Patrick M. Beardsley

et al.

Pharmacology Biochemistry and Behavior, Journal Year: 2025, Volume and Issue: unknown, P. 174004 - 174004

Published: March 1, 2025

Language: Английский

Citations

0
Ultrasensitive Isomer Discrimination: A Joint Surface‐Enhanced Raman Scattering (SERS) Spectroscopy and Machine Learning Strategy DOI Creative Commons
Verónica Montes‐García, Víctor F. Martín, Manuel Obelleiro‐Liz

et al.

Advanced Sensor Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 21, 2025

Abstract Isomer discrimination is of paramount importance across various sectors, including pharmaceuticals, agriculture, and the food industry, owing to their unique physicochemical characteristics. Because extremely similar characteristics, traditional analytical methods fail or encounter severe limitations in isomer discrimination. To overcome this grand challenge, a novel sensing strategy proposed based on surface‐enhanced Raman scattering (SERS) substrates (i.e., plasmonic platforms) combined with machine learning algorithms. These platforms exhibit exceptional signal uniformity wide regions sensitivity, enabling structural isomers (hydroquinone, resorcinol, pyrocatechol), geometric ((Z/E)‐stilbene, (Z/E)‐resveratrol), optical (R/S‐ibuprofen). Notably, for analysis isomers, 1‐naphthalenethiol employed as probe facilitate specific orientation surface platform through, first time, π–π interactions. The integration methodologies, such Partial Least Squares Regression Artificial Neural Networks, significantly enhances both quantitative classification accuracy, achieving detection limits low 2 × 10⁻⁸ m . Validation commercially available ibuprofen samples shows excellent agreement circular dichroism results, highlighting method's robustness precision. provides versatile, ultrasensitive, reliable solution discrimination, broad applications environmental monitoring, clinical diagnostics.

Language: Английский

Citations

0
Synthetic cannabinoid receptor agonists exacerbate fentanyl-elicited respiratory depression and confer resistance to naloxone rescue in mice DOI

J S James,

Jessica Thrush,

Taher M Yusufali

et al.

Drug and Alcohol Dependence, Journal Year: 2025, Volume and Issue: 272, P. 112672 - 112672

Published: April 15, 2025

Language: Английский

Citations

0
Fentanyl Overdose Causes Prolonged Cardiopulmonary Dysregulation in Male SKH1 Mice DOI Creative Commons

Mackenzie Newman,

Heather Connery,

Swapna Kannan

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(7), P. 941 - 941

Published: July 14, 2024

Fentanyl overdose is a survivable condition that commonly resolves without chronic overt changes in phenotype. While the acute physiological effects of fentanyl overdose, such as opioid-induced respiratory depression (OIRD) and Wooden Chest Syndrome, represent immediate risks lethality, little known about longer-term systemic or organ-level impacts for survivors. In this study, we investigated single, bolus on components cardiopulmonary system up to one week post. SKH1 mice were administered subcutaneous at highest non-lethal dose (62 mg/kg), LD10 (110 LD50 (135 before euthanasia 40 min, 6 h, 24 7 d post-exposure. The cerebral cortex, heart, lungs, plasma assayed using an immune monitoring 48-plex panel. results showed significantly dysregulated cytokine, chemokine, growth factor concentrations compared time-matched controls, principally hearts, then lungs lesser extent, length with cortex largely unaffected. Major significant analytes contributing variance included eotaxin-1, IL-33, betacellulin, which generally downregulated across time. study suggest toxicity may persist from single have wide implications endurance expanding population

Language: Английский

Citations

0