Suppression of ergosterol biosynthesis by dictamnine confers resistance to gray mold on harvested fruit DOI
Kui Liu, Yuhan Liu,

Yangzhi Liu

et al.

Food Microbiology, Journal Year: 2024, Volume and Issue: 127, P. 104681 - 104681

Published: Nov. 17, 2024

Language: Английский

Chemical compositions, health benefits, safety assessment, and industrial applications of wampee (Clausena lansium (Lour.) Skeels): A comprehensive review DOI

L. Ding,

Xiaoze Liu,

Tao Fei

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104922 - 104922

Published: Feb. 1, 2025

Language: Английский

Citations

1

A concise enzyme cascade enables the manufacture of natural and halogenated protoberberine alkaloids DOI Creative Commons
Fei Li, Zhenbo Yuan, Yue Gao

et al.

Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)

Published: Feb. 23, 2025

Language: Английский

Citations

0

Quality control methods established in view of the characteristics of component type of Yuhuang Shengji ointment based on HPLC, ICP-MS and GC e-nose DOI Creative Commons
Kewei Wang,

Xilong Qian,

Ying Zhang

et al.

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY (CHINESE VERSION), Journal Year: 2025, Volume and Issue: unknown, P. 100550 - 100550

Published: April 1, 2025

Language: Английский

Citations

0

From pathway to products: Canadian achievements in plant specialized metabolism DOI
Karen Cristine Gonçalves dos Santos, Fatima Awwad, Natacha Mérindol

et al.

Genome, Journal Year: 2025, Volume and Issue: 68, P. 1 - 23

Published: Jan. 1, 2025

Canada has made significant contributions to the field of plant biochemistry, with numerous researchers actively focusing on elucidating biosynthetic pathways specialized metabolites and producing these compounds in heterologous systems, such as bacteria, yeast, or other species. The review aims highlight strengths Canadian research this domain over last three decades. It will describe advances pathway elucidation, enzyme characterization, production enzymes particularly areas alkaloids, terpenoids, phenolic compounds. have not only pivotal scientific discoveries but also ensured continuity excellence by mentoring new generations principal investigators metabolites. These warrant recognition financial support retain future talent maintain Canada's leadership progress global stage.

Language: Английский

Citations

0

Acetylcholinesterase inhibition studies of alkaloid components from Crinum asiaticum var. sinicum : in vitro assessments by molecular docking and molecular dynamics simulations DOI
Ngo Viet Duc,

Vu Thi Trang,

Hoang Le Tuan Anh

et al.

Journal of Asian Natural Products Research, Journal Year: 2023, Volume and Issue: 26(5), P. 652 - 662

Published: Oct. 27, 2023

Alkaloids are among the most important and best-known secondary metabolites as sources of new drugs from medicinal plants marine organisms. A phytochemical investigation whole plant Crinum asiaticum var. sinicum resulted in isolation seven alkaloids (1–7), including one dimeric compound, bis-(-)-8-demethylmaritidine (1). Their structures were elucidated using NMR HR-ESI-MS. The absolute configuration compound 1 was established by circular dichroism spectroscopy. All isolated compounds evaluated for their inhibitory effects on acetylcholinesterase (AChE) activity vitro. Among them, exhibited potent AChE inhibition. Moreover, molecular docking dynamics simulations carried out active to investigate binding interactions behavior protein-ligand complex. Therefore, may be a potential candidate effectively treating Alzheimer's disease.

Language: Английский

Citations

4

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy DOI Creative Commons
Siyu Li, Xinyu Lin,

Lijuan Duan

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: June 19, 2024

Graphical Abstract Therapeutic mechanisms of natural alkaloids in epilepsy treatment.

Language: Английский

Citations

1

Molecular imaging of excitability difference between alkaloids/salts (nicotine, nicotinic benzoate, caffeine and arecoline hydrobromide) DOI
Dawei Yan, Xiaomin Liu, Yihan Gao

et al.

Journal of Pharmacological and Toxicological Methods, Journal Year: 2024, Volume and Issue: unknown, P. 107569 - 107569

Published: Oct. 1, 2024

Language: Английский

Citations

0

Transcriptome analysis of Citrus Aurantium L. to study synephrine biosynthesis during developmental stages DOI Creative Commons
Can Zhong,

Xitao Yang,

Juan Niu

et al.

PeerJ, Journal Year: 2024, Volume and Issue: 12, P. e17965 - e17965

Published: Sept. 9, 2024

Citrus aurantium L., sometimes known as “sour orange,” is an important Chinese herb with young, immature fruits, or “zhishi,” that are high in synephrine. Synephrine a commonly utilized natural chemical promising applications effectively increasing metabolism, heat expenditure, energy level, oxidative fat, and weight loss. However, little about the genes pathways involved synephrine production during critical developmental stages of C. which limits development industry. According to this study, concentration gradually decreased fruit developed. Transcriptome sequencing was used examine DEGs associated connections served foundation for creating synephrine-rich L. Comparisons conducted between different obtain DEGs, number varied from 690 3,019. Tyrosine tryptophan biosynthesis, glycolysis/gluconeogenesis, pentose phosphate pathway, phenylalanine, tyrosine metabolism were main KEGG substantially enriched. The results showed 25 among these may be related synthesis. WGCNA one-way ANOVA analysis adoption variance across groups suggested 11 might play crucial role synthesis should therefore further analyzed. We also selected six at random analyzed their expression levels by RT-qPCR, repeatability reliability demonstrated our finished RNA-seq study results. These useful selecting modifying increase quantity sour oranges.

Language: Английский

Citations

0

Suppression of ergosterol biosynthesis by dictamnine confers resistance to gray mold on harvested fruit DOI
Kui Liu, Yuhan Liu,

Yangzhi Liu

et al.

Food Microbiology, Journal Year: 2024, Volume and Issue: 127, P. 104681 - 104681

Published: Nov. 17, 2024

Language: Английский

Citations

0