Pulsed electromagnetic field ameliorates the progression of osteoarthritis via the Sirt1/NF-κB pathway

Arthritis Research & Therapy, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 14, 2025

Abstract Background Pulsed electromagnetic field (PEMF) is a non-invasive treatment that utilizes fields to reduce inflammation and promote tissue repair. However, PEMFs’ anti-inflammatory effect on osteoarthritis (OA) the potential mechanism has not been fully elucidated. Methods Human chondrocytes (C28/I2) were stimulated with interleukin (IL)-1β or without of PEMF. CCK-8 assay Kit was used detect cell viability. RT-qPCR, ELISA, immunofluorescent staining western blot analyze relative markers inflammatory response extracellular matrix (ECM) under PEMF related mechanism. Besides, significance role Sirt1 assessed by using inhibitor (EX-527). Moreover, immunohistochemistry immunofluorescence carried out evaluate curative OA mice induced destabilization medial meniscus (DMM). Results inhibited IL-1β-mediated expression pro-inflammatory factors. alleviated IL-1β-induced degradation ECM increasing Col2a1 ACAN, while inhibiting MMP13 ADAMTS5. At level, increased activation NF-κB pathway. Furthermore, blocking EX-527 attenuated inhibition pathway in chondrocytes. In vivo, PEMF-treated showed low modified mankin scores, reduced number osteophytes preserved joint structure. Conclusions Our results suggest inhibits blocks factors activating Sirt1, which may be novel strategy for OA.

Language: Английский

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Application and progress of magnetic field therapy for spinal cord injury

Journal of Neurorestoratology, Journal Year: 2025, Volume and Issue: unknown, P. 100205 - 100205

Published: March 1, 2025

Language: Английский

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Are New Approaches Needed to Solidify Pulsed Electromagnetic Fields and Osteoarthritis Associations: A 50-year Retrospective Showing Promise but No Definitive Lab or Clinical Research Conclusions (1974-2024)

Published: April 19, 2024

Background: Osteoarthritis, a painful oftentimes disabling joint disorder affects many older adults and others globally. Involving progressive distinctive biologic as well structural alterations of the articular cartilage tissue lining freely moving joints such knee often underlying bone condition is presently considered incurable. Objective: In seeking to advance therapies for this condition, report was designed examine rationale potential efficacy of, applying pulsed electromagnetic fields clinically purposes reducing osteoarthritis pain other related symptoms disease features, especially through its impact on cartilage, most consistently implicated in disease. Methods: Available English language literature published largely PUBMED between 1974 2024 were reviewed a) general; b) specifically whether favourable changes itself might be expected from application some form an osteoarthritic c) why occurs, if observed. Key search terms used were: Pulsed Electromagnetic Fields, Cartilage, Chondrocyte, Disability Osteoarthritis. Results: The data revealed large body basic clinical research field has persisted over time with no definitive conclusion, but tentative support possible use mitigating improving homeostasis function via several pathways. Conclusion: Further carefully controlled short long term alongside comparable lab studies appear strongly indicated may help better validate more mainstream and/or targeted one or forms facilitating reparative processes osteoarthritis, while pain, inflammation, stiffness magnitude derangement dysfunction.

Language: Английский

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Effects of pulsed electromagnetic field and retrowalking in patients with chronic non-specific low back pain: a pilot study

Revista Pesquisa em Fisioterapia, Journal Year: 2024, Volume and Issue: 14, P. e5608 - e5608

Published: Aug. 9, 2024

INTRODUCTION: Chronic non-specific low back pain (CNSLBP) is a major worldwide condition that has severe emotional, social, and economic consequences. Management difficult, requiring the development of new, effective, safe approaches. OBJECTIVES: This study was conducted to examine effects Pulsed Electromagnetic Fields (PEMF) retrowalking on pain, disability, spinal mobility, hamstring tightness, balance, kinesiophobia in patients with chronic pain. MATERIALS AND METHODS: Participants (n= 48) CNSLBP were randomised into four groups; Group A: Conventional group, B: PEMF C: D: group. The interventions given three times per week for six weeks. outcomes mobility kinesiophobia, measured at baseline after 6 RESULTS: result suggested significant improvement balance. However, no (flexion extension ROM) observed during sixth between-group comparison. maximum seen group D followed by C B comparison A. CONCLUSION: It can be concluded when combination significantly decrease improve balance

Language: Английский

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In Vitro Regulation of Collective Cell Migration: Understanding the Role of Physical and Chemical Microenvironments

Progress in Biophysics and Molecular Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

Language: Английский

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Optimization of Pulsed Electromagnetic Field Parameters for Knee Osteoarthritis Treatment and its Clinical Validations

Journal of Medical and Biological Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 10, 2024

Language: Английский

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