BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Nov. 7, 2024
Long-COVID is a new multisectoral healthcare challenge. This study aims at understanding experiences, knowledge, attitudes and (information) needs that GPs had have in relation to how these evolved since the beginning of COVID-19 pandemic.
Language: Английский
The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(8), P. 845 - 855
Published: April 22, 2024
Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.
Language: Английский
Citations
62
Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 27, 2025
The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had devastating global impacts since its emergence in late 2019. However, it also prompted an unprecedented scientific response (Cauchemez et al., 2024). While acute phase of pandemic largely subsided due to quarantining, vaccination efforts and improved treatments, a new challenge emerged form post-COVID inflammatory syndromes. A hallmark severe was excessive inflammation involving multiple organ systems, characterized cytokine storms, coagulation dysfunction, tissue damage. Even after recovery from infection, many patients continue experience persistent symptoms affecting various body condition now known as "long COVID" or "post-acute sequelae infection" (PASC) (Barber 2021, Davis 2023; Liu Porter 2023).The complex nature syndromes presents significant healthcare systems worldwide. Symptoms can vary widely between may affect including respiratory, cardiovascular, neurological, gastrointestinal systems. Common complaints include fatigue, cognitive dysfunction ("brain fog"), shortness breath, anxiety, depression, sleep disturbances. underlying mechanisms these are not fully understood but thought involve ongoing inflammation, autonomic potential autoimmune processes triggered initial infection.Conventional medical approaches treating have shown limited success, highlighting need for novel integrative strategies. Natural products plant-based medicines long history use conditions modulating immune function. Many compounds well-documented anti-inflammatory, antioxidant, immunomodulatory properties that could potentially address multifaceted syndromes.The impact COVID cannot be overstated. With millions people worldwide experiencing following social, economic, burdens immense. development effective treatments is therefore paramount importance. As we navigate long-term consequences interdisciplinary collaboration conventional complementary medicine will crucial. By combining strengths therapeutic diagnostic methods, better equipped tackle challenges posed studies this Research Topic demonstrate such pave way future research critical area.This explored innovative using natural products, medicinal plants, nutrients, methods. articles collection investigate range their anti-inflammatory help alleviate lingering symptoms. Additionally, nutritional interventions traditional techniques support with examined.The presented explores several promising avenues interventions. These specific vitamins nutrients function reduce herbal extracts properties, comprehensive lifestyle addressing diet physical activity. targeting aspects simultaneously, offer advantages over single-target pharmaceutical interventions.Moreover, delves into methods complement assessing monitoring provide valuable insights interplay physiological imbalances, allowing more personalized holistic treatment our understanding continues evolve, provides options work concert improve outcomes affected patients.1. Deng al. examined relationship fat-soluble vitamin status antibody responses cohort 141 healthy adults. They found higher plasma D levels were associated lower anti-SARS-CoV-2 titers, both wild-type Omicron variants. This unexpected finding suggests play role vaccine-induced immunity, further on optimal vaccine efficacy.2. Pourfarzi conducted randomized controlled trial testing web-based intervention focused nutrition activity preventing COVID-19. study involved 303 women aged 30-60 who previously contracted group received online educational sessions After 4 weeks, showed improvements weight, BMI, status, compared controls. Importantly, incidence infection during follow-up period, suggesting modifications risk.3. Gaylis evaluated nutraceutical supplement containing compounds, β-caryophyllene, pregnenolone, herbs vitamins, In open-label 51 participants, significantly weakness, issues, breath weeks treatment. demonstrated multi-component approach symptomatology COVID.4. Joung investigated effects extract (Myelophil) fatigue patients. non-randomized, observational study, without control group. Myelophil administered 49 participants (18 males, 31 females) study. administration, scores, quality life measures. evidence efficacy managing symptoms.5. Bioinformatics biology employed Qain identification hub genes, shared pathways, molecular biomarkers, candidate therapeutics management sepsis sepsis-induced ARDS context infection. 189 differentially expressed genes (DEGs) among datasets identified. Construction protein-protein interaction networks revealed six (CD247, CD2, CD40LG, KLRB1, LCN2, RETN) exhibited alterations across COVID-19, sepsis, geriatric ARDS. Functional analysis underscored interconnection sepsis/sepsis-ARDS enabling targets, transcription factor-gene interactions, DEG-microRNA co-regulatory networks, prospective drug chemical compound interactions genes.6. Qian Zeng Jinhua Qinggan Granules (JHQG), Traditional Chinese Medicine formulation, mass spectrometry, network pharmacology, single-cell RNA sequencing analysis. researchers identified 73 components JHQG constructed showing target proteins, cells. Results suggest mitigate inhibiting activated neutrophils, monocytes, plasmoblasts, effector T cells peripheral blood. findings JHQG's mechanism action safe viral infections like COVID-19.7. Ahmad published first survey reviewing application AI methodologies Long COVID. Twenty papers met inclusion criteria (innovative clear results 2020) employing ML NLP data discussed. Thirteen other seven applying text mining data. data, implemented, accuracy, precision each twenty reviewed detail. analyze temporal symptom physiologically monitor time, assist detecting early signs worsening COVID, facilitating timely adaptation protocols hence improving patient outcome. made strides exploring collected diverse interventions, formulations modifications. Collectively, those underscores importance opens investigations area public health.It important note while encouraging, needed establish safety Large-scale, trials crucial validating determining protocols. medications must carefully considered ensure safety.
Language: Английский
Citations
1
动物学研究, Journal Year: 2024, Volume and Issue: 45(4), P. 747 - 766
Published: Jan. 1, 2024
The distribution of the immune system throughout body complicates
Language: Английский
Citations
4
BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)
Published: Feb. 4, 2025
Language: Английский
Citations
0
Psychiatry Research, Journal Year: 2025, Volume and Issue: 347, P. 116413 - 116413
Published: Feb. 19, 2025
Language: Английский
Citations
0
Infectious Diseases & Immunity, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Long coronavirus disease (COVID) is defined as the continuation or development of new symptoms three months after severe acute respiratory syndrome 2 (SARS-CoV-2) infection, and that last for at least two months, with no other explanation their cause. This includes various clinical manifestations affect multiple organ systems, such complications in respiratory, cardiovascular, neurological, musculoskeletal systems. The most commonly reported include fatigue, cognitive dysfunction, dyspnea, chest pain; however, prevalence severity these vary greatly among individuals. underlying mechanisms long COVID are complex multifaceted, encompassing viral persistence, immune system mitochondrial abnormalities, endothelial impairment, alterations microbiome. Further, has imposed a significant burden on individuals, healthcare economy by impairing an individual’s quality life functional capacity, thereby increasing costs demand care rehabilitation services. review summarizes definition, phenotypes, mechanisms, current treatment advancements highlights specific research directions future investigation.
Language: Английский
Citations
0
Viruses, Journal Year: 2025, Volume and Issue: 17(3), P. 394 - 394
Published: March 11, 2025
Data are limited for assessing the effect of COVID infection on endothelial function, pre- and post-pandemic. The objective this study was to assess changes in pre-pandemic cardiovascular parameters after COVID-19 infection. This prospective cohort used EndoPAT2000 Itamar Medical Ltd., Caesarea, Israel, measure augmentation index (AI; arterial elasticity) reactive hyperemic (RHI; function). Markers inflammation, gut integrity were collected at post-pandemic visits. COVID-negative COVID-positive participants matched covariates, AI ≥ 5.0 defined as having worse AI. Among 156 participants, 50% had documented Groups balanced (p > 0.05) characteristics. Increases oxLDL = 0.03) observed group, a negative inflammatory markers (sVCAM-1, sTNF-RI, sTNF-RII, sCD14) (I-FABP, BDG) compared < 0.05). There 16.7% 0.02) increase proportion with 5.0, without significant change 0.09) among group. status, female sex, higher IL-6 sCD163 associated an is independently stiffness. For survivors, sex inflammation
Language: Английский
Citations
0
Chinese Medical Journal, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Topics in Pain Management, Journal Year: 2025, Volume and Issue: 40(10), P. 1 - 5
Published: April 13, 2025
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 19, 2025
Individuals living with long COVID experience a range of symptoms that affect their ability to carry out daily activities or participate in social and community life. This study aimed analyze association between functional disability the occurrence symptoms, as well effect symptom persistence time on disability. is cross-sectional using data from SulCovid-19 study, which interviewed individuals who had COVID-19 December 2020 March 2021. The outcome was assessed Basic Activities Daily Living (BADL) Instrumental (IADL) scales, while exposures were COVID. Adjusted analyses outcomes exposures, stratified by after acute phase infection, performed Poisson regression robust variance adjustment. prevalence BADL 4.8% (95%CI 4.0;5.6), for IADL disability, it 8.4% 7.4;9.4). main associated dyspnea, dry cough sore throat, IADL, they joint pain, muscle loss sensation, nasal congestion, throat runny nose. When tertiles relationship found ageusia and, congestion 3rd tertile, only be related tertile. Long wiht limitations capacity adults seniors. findings can used guide care rehabilitation disabilities have COVID-19, particularly referral appropriate health professionals.
Language: Английский
Citations
0