Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1702 - 1702
Published: Oct. 16, 2024
Pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and secondary (SPF), is a progressive lung disease that significantly impairs respiratory function. Accurate differentiation between IPF SPF crucial for effective management. This study explores the association hepatic conditions, evaluating utility of various hemogram-derived ratios scores in distinguishing SPF.
Language: Английский
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107659 - 107659
Published: Feb. 1, 2025
Ribonucleic acid (RNA) aptamers are single-stranded RNAs that bind to target proteins or other molecules with high specificity and affinity, modulating biological functions through distinct mechanisms. These can act n as antagonists block pathological interactions, agonists activate signaling pathways, delivery vehicles for therapeutic cargos such siRNAs miRNAs. The advances in RNA nanotechnology further enhances the versatility of aptamers, offering scalable platforms engineering. In this review, we have summarized recent developments aptamer-mediated provide an overview its potential treating cardiovascular respiratory disorders, including atherosclerosis, acute coronary syndromes, heart failure, lung cancer, pulmonary hypertension, asthma, chronic obstructive disease (COPD), injury, viral infections, fibrosis. By integrating aptamer technologies innovative systems, hold revolutionize treatment landscape cardiopulmonary diseases.
Language: Английский
Citations
1
Critical Care, Journal Year: 2024, Volume and Issue: 28(1)
Published: Oct. 31, 2024
Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of various respiratory diseases. Effective monitoring lung crucial for optimal management improved outcomes patients This review describes acute chronic diseases characterized by significant current clinical tools assessing health. Furthermore, we summarized mechanisms cell death observed in these highlighted recently identified biomarkers plasma indicative to specific types scaffold structure lung. Last, propose an artificial intelligence-driven model assess disease predict mortality prognosis, aiming achieve precision personalized medicine.
Language: Английский
Citations
6
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Oct. 7, 2024
Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disorder for which effective treatments remain limited. Recent investigations revealed potential link between altered glucose metabolism the activation of fibroblasts, key cells responsible generating depositing extracellular matrix proteins within interstitium during IPF development.
Language: Английский
Citations
4
OMICS A Journal of Integrative Biology, Journal Year: 2025, Volume and Issue: 29(3), P. 87 - 95
Published: Feb. 3, 2025
Innovation in drug discovery for human diseases stands to benefit from systems science and next-generation phenomics approaches. An example is idiopathic pulmonary fibrosis (IPF) that a chronic disorder leading respiratory failure which preventive therapeutic medicines are sorely needed. Matrix metalloproteinases (MMPs), particularly MMP1 MMP7, have been associated with IPF pathogenesis thus relevant discovery. This study evaluates the comparative potentials of doxycycline, pirfenidone, nintedanib relation MMP7 using molecular docking, dynamics simulations, approach. Adsorption, distribution, metabolism, excretion, toxicity analysis revealed doxycycline adhered Lipinski's rule five, while pirfenidone exhibited no violations. The favorable safety profiles, lethal dose 50 values being 2240kg, 580, 500 mg/kg, respectively. Homology modeling validated accuracy structures target proteins, is, MMP7. Protein Contacts Atlas tool, platform broadens scope research, was employed visualize protein contacts at atomic levels, revealing interaction surfaces Docking studies superior binding affinities candidate proteins (-6.9 kcal/mol -7.9 MMP7) compared pirfenidone. Molecular simulations further demonstrated stability protein-ligand complexes. These findings highlight notable potential future therapeutics innovation. By integrating silico approach, this opens up new avenues development possibly, precision/personalized consider signatures candidates each patient.
Language: Английский
Citations
0
Cell Biology and Toxicology, Journal Year: 2025, Volume and Issue: 41(1)
Published: Feb. 7, 2025
Autophagy related genes (ATGs) play essential roles in maintaining cellular functions, although biological and pathological alterations of ATG phenotypes remain poorly understood. To address this knowledge gap, we utilized the single-cell sequencing technology to elucidate transcriptomic atlas ATGs lung diseases, with a focus on epithelium lymphocytes. This study conducted comprehensive investigation into RNA profiles tissues obtained from healthy subjects patients different diseases through (scRNA-seq), including COVID-19 acute damage, idiopathic pulmonary fibrosis (IPF), chronic obstructive disease (COPD), systemic sclerosis (SSC), adenocarcinoma (LUAD). Our findings revealed significant variations expression across epithelial cell subsets, e.g., over-expression MAPK8 basal cells, ATG10 club BCL2 goblet subset. The changes autophagy-related pathways varied between lymphocyte subsets. We identified disease-associated expression, BCL2, BCL2L1, PRKCD, PRKCQ inflammatory (COPD IPF), MAP2K7, MAPK3, RHEB cancer (LUAD), as compared normal tissues. Key ligand-receptor pairs (e.g., CD6-ALCAM, CD99-CD99) signaling APP, CD74) might serve biomarkers for diseases. evaluate responses external challenges, examined lines exposed cigarette smoking extract (CSE), lysophosphatidylcholine (lysoPC), lipopolysaccharide (LPS), cholesterol at various doses durations. Notable were observed CFLAR, EIF2S1, PPP2CA, PPP2CB A549 H1299 against CSE LPS. heterogeneity was dependent pathologic conditions, well among phenotypes, behaviors, severity In conclusion, our data provide new insights biology pathogenesis, implications progression prognosis.
Language: Английский
Citations
0
BMC Pulmonary Medicine, Journal Year: 2024, Volume and Issue: 24(1)
Published: July 19, 2024
Abstract Background This study aimed to investigate risk factors for acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) based on baseline high-resolution computed tomography (HRCT). Methods prospective observational enrolled patients with IPF treated at the General Hospital Ningxia Medical University between January 2019 and 2021. HRCT-derived quantitative parameters were analyzed. Results A total 102 [92 (90.2%) males a mean age 67 years] included, median follow-up 32 (24-40.5) months. AE occurred in 30 (29.4%) patients. Multivariable logistic regression analysis identified Doppler transthoracic echocardiography suggestive hypertension (PH) (13.43; 95% CI: 4.18–41.09; P < 0.001), honeycombing (OR 1.08; 1.02–1.14; = 0.013), whole lung volume 0.99; 0.99-1.00; 0.037) as independent AE-IPF. The combination PH, honeycombing, volume, percentage predicted forced vital capacity (FVC% pred) showed high area under curve from receiver operating characteristic curves 0.888, sensitivity 90% specificity 78%. Conclusions emphasizes that CT (honeycombing, volume) may serve FVC% pred, PH aid predicting
Language: Английский
Citations
2
Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)
Published: Aug. 30, 2024
Eosinophils, traditionally associated with allergic phenomena, play a pivotal role in inflammatory responses. Despite accumulating evidence suggesting their pro-inflammatory function upon activation, the underlying mechanisms governing eosinophil activation remain incompletely characterized. In this study, we investigate local of pulmonary and colon eosinophils within microenvironment. Leveraging transcriptional sequencing, identify TGF-β as putative regulator leading to secretion granule proteins, including peroxidase. Genetic deletion receptors on resulted inhibition peroxidase synthesis, affirming significance signaling activation. Using models HDM-induced asthma DSS-induced colitis, demonstrate indispensability TGF-β-driven both disease contexts. Notably, while did not significantly influence asthmatic inflammation, its knockout conferred protection against experimental colitis. This study delineates distinct pattern responses, highlighting regulating behavior. These findings deepen our comprehension eosinophil-related pathophysiology may pave way for targeted therapeutic approaches diseases.
Language: Английский
Citations
2
International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 661 - 679
Published: Nov. 22, 2024
Lung cancer is a leading cause of cancer-related mortality worldwide, characterized by its aggressive nature and poor prognosis. Matrix metalloproteinases (MMPs), family zinc-dependent endopeptidases, play pivotal role in the progression lung cancer. They contribute to tumor invasion, metastasis, angiogenesis, modulation microenvironment degrading extracellular matrix components regulating various cellular signaling pathways. Elevated levels specific MMPs, such as MMP-2, MMP-9, MMP-14, have been associated with advanced disease stages reduced survival rates. As such, MMPs emerged valuable biomarkers for diagnosis, prognosis, prediction treatment responses This review aims provide comprehensive overview current understanding cancer, highlighting their diagnostic prognostic significance, well potential therapeutic targets. Despite initial setbacks developing broad-spectrum MMP inhibitors, recent advancements spurred interest more selective inhibitors that minimize off-target effects enhance efficacy. Furthermore, combining MMP-targeted therapies conventional treatments, chemotherapy immunotherapy, holds promise improving clinical outcomes. Future research directions include exploring novel regulatory mechanisms activity, integrating into personalized medicine approaches. field progresses, targeting may offer new avenues improve prognosis patients, making this promising area investigation.
Language: Английский
Citations
1
Medicina, Journal Year: 2024, Volume and Issue: 60(10), P. 1702 - 1702
Published: Oct. 16, 2024
Pulmonary fibrosis, including idiopathic pulmonary fibrosis (IPF) and secondary (SPF), is a progressive lung disease that significantly impairs respiratory function. Accurate differentiation between IPF SPF crucial for effective management. This study explores the association hepatic conditions, evaluating utility of various hemogram-derived ratios scores in distinguishing SPF.
Language: Английский
Citations
1