Photodynamic antibacterial chemotherapy activities of P(V) and Ga(III) triarylcorroles and their silver nanoparticle conjugates DOI
Rodah C. Soy,

Pertunia R. Macigane,

John Mack

et al.

Journal of Porphyrins and Phthalocyanines, Journal Year: 2024, Volume and Issue: 28(07), P. 469 - 486

Published: July 1, 2024

Silver nanoparticle (AgNP) conjugates of two series P(V) and Ga(III) corroles with 4-thiomethylphenyl- (1-P V Cor-AgNPs 1-Ga III Cor-AgNPs), thien-3-yl- (2-P 2-Ga thien-2-yl- (3-P 3-Ga Cor-AgNPs) 5-bromothien-2-yl- (4-P 4-Ga meso-aryl rings have been synthesized characterized, so that their in vitro photodynamic antimicrobial chemotherapy (PACT) properties could be investigated against S. aureus E. coli. The 4-P Cor complexes are reported for the first time this context, while 1-3-P Corr 1-3-Ga were previously during a study therapy (PDT) activity gold MCF-7 breast cancer cells. heavy atom effects bromine atoms result increases singlet oxygen quantum yield values to 0.59 0.72, respectively, from 0.47 0.69 3-P Cor. Conjugation AgNPs results further slight due an external effect significantly enhances photostability dyes. 1-4-P found higher PACT activities than 1-4-Ga lower aggregation since there is trans-axial ligation. Complete eradication coli Log[Formula: see text] reduction 7.04 was achieved 20μg.mL[Formula: 3-4-P 3-4-Ga despite difficulties typically encountered context Gram-([Formula: bacteria.

Language: Английский

Blue-Light-Activated Water-Soluble Sn(IV)-Porphyrins for Antibacterial Photodynamic Therapy (aPDT) against Drug-Resistant Bacterial Pathogens DOI
Tushar Nagarajan,

M. Gayathri,

John Mack

et al.

Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: 21(5), P. 2365 - 2374

Published: April 15, 2024

Antimicrobial resistance has emerged as a global threat to the treatment of infectious diseases. Antibacterial photodynamic therapy (aPDT) is promising alternative approach and highly suitable for cutaneous bacterial infections through topical applications. aPDT relies on light-responsive compounds called photosensitizer (PS) dyes, which generate reactive oxygen species (ROS) when induced by light, thereby killing cells. Despite several previous studies in this area, molecular details targeting cell death mediated PS dyes are poorly understood. In study, we further investigate antibacterial properties two water-soluble Sn(IV) tetrapyridylporphyrins that were quaternized with methyl hexyl groups (1 2). follow-up demonstrate Sn(IV)-porphyrins can be photoexcited blue light (a 427 nm LED) exhibit various levels bactericidal activity against both Gram-(+) Gram-(−) strains bacteria. Using localization fluorescence microscopy, show 2 targets membrane more effectively than 1 exhibits comparatively higher activity. multiple reporters, photoactivation results extensive collateral damage cells including DNA cleavage, damage, delocalization central systems necessary growth division. summary, investigation provides deep insights into mechanism Sn(IV)-porphyrins. Moreover, our offers new method evaluating PS, may inspire discovery enhanced

Language: Английский

Citations

3
Photophysical Properties of Meso-tetrakis(p-methoxycarbonylphenyl) N-confused Porphyrin DOI
Lili Wang,

Ying-Hong Mu,

Wanhong Li

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: 1340, P. 142536 - 142536

Published: April 29, 2025

Language: Английский

Citations

0
Influence of supramolecular self-assembly of oppositely charged Co- and Sn-porphyrins on the their spectral-luminescent properties in aqueous and aqueous micellar media of ionic surfactants DOI

Elena Yu. Kaigorodova,

G.M. Mamardashvili,

Ivan Yu. Kurochkin

et al.

Optical Materials, Journal Year: 2024, Volume and Issue: 154, P. 115805 - 115805

Published: July 11, 2024

Language: Английский

Citations

1
Photodynamic antibacterial chemotherapy activities of P(V) and Ga(III) triarylcorroles and their silver nanoparticle conjugates DOI
Rodah C. Soy,

Pertunia R. Macigane,

John Mack

et al.

Journal of Porphyrins and Phthalocyanines, Journal Year: 2024, Volume and Issue: 28(07), P. 469 - 486

Published: July 1, 2024

Silver nanoparticle (AgNP) conjugates of two series P(V) and Ga(III) corroles with 4-thiomethylphenyl- (1-P V Cor-AgNPs 1-Ga III Cor-AgNPs), thien-3-yl- (2-P 2-Ga thien-2-yl- (3-P 3-Ga Cor-AgNPs) 5-bromothien-2-yl- (4-P 4-Ga meso-aryl rings have been synthesized characterized, so that their in vitro photodynamic antimicrobial chemotherapy (PACT) properties could be investigated against S. aureus E. coli. The 4-P Cor complexes are reported for the first time this context, while 1-3-P Corr 1-3-Ga were previously during a study therapy (PDT) activity gold MCF-7 breast cancer cells. heavy atom effects bromine atoms result increases singlet oxygen quantum yield values to 0.59 0.72, respectively, from 0.47 0.69 3-P Cor. Conjugation AgNPs results further slight due an external effect significantly enhances photostability dyes. 1-4-P found higher PACT activities than 1-4-Ga lower aggregation since there is trans-axial ligation. Complete eradication coli Log[Formula: see text] reduction 7.04 was achieved 20μg.mL[Formula: 3-4-P 3-4-Ga despite difficulties typically encountered context Gram-([Formula: bacteria.

Language: Английский

Citations

0