Molecular Markers in Oral Lichen Planus - Insight into Pathogenesis DOI Creative Commons
Maria Zaharieva Mutafchieva, Milena Draganova-Filipova, Georgi Tomov

et al.

Head and Neck Pathology, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 26, 2025

Abstract Purpose Oral lichen planus (OLP) is a chronic inflammatory disease, characterized by immune-mediated basal keratinocyte apoptosis. In recent years the importance of programmed cell death for tissue destruction in OLP has been disputed, while at same time an increased proliferative index reported epithelium these lesions. considered as precancerous condition. This study investigated expression pro-apoptotic, anti-apoptotic and markers lesions attempt to understand more about pathogenesis malignant potential disease. Methods Twenty patients with histologically confirmed were compared ten healthy controls through immunohistochemical analysis levels p53, p63, bcl-2, Ki-67 COX-2. Results The results demonstrated significantly decreased p63 normal oral mucosa. Ki-67, COX-2 not different from those control group. A significant association was found between ( p = 0.001), well p53 0.016). Expression apoptotic appeared be independent each other 0.44). intensity any five analyzed related severity clinical manifestation. Conclusions obtained suggest that apoptosis may dominant mechanism disease’s pathogenesis. Decreased on hand appears play important role. Among possible effects this protein deficiency are activation death, cycle arrest, cellular senescence, or anoikis; suppression proliferation changes differentiation. observed reduction Ki67 bcl-2 predisposes epithelial thinning, erosions and/or ulcers. For presented cohort, there no molecular evidence

Language: Английский

Laser patterned microcoagulation (LPM) in the management of desquamative gingivitis secondary to oral lichen planus: A randomized controlled pilot clinical trial (LPM TRIAL) DOI

Saravanan Sampoornam Pape Reddy,

Harjeet Singh,

Delfin Lovelina Francis

et al.

Lasers in Medical Science, Journal Year: 2025, Volume and Issue: 40(1)

Published: April 11, 2025

Language: Английский

Citations

0
Molecular Markers in Oral Lichen Planus - Insight into Pathogenesis DOI Creative Commons
Maria Zaharieva Mutafchieva, Milena Draganova-Filipova, Georgi Tomov

et al.

Head and Neck Pathology, Journal Year: 2025, Volume and Issue: 19(1)

Published: March 26, 2025

Abstract Purpose Oral lichen planus (OLP) is a chronic inflammatory disease, characterized by immune-mediated basal keratinocyte apoptosis. In recent years the importance of programmed cell death for tissue destruction in OLP has been disputed, while at same time an increased proliferative index reported epithelium these lesions. considered as precancerous condition. This study investigated expression pro-apoptotic, anti-apoptotic and markers lesions attempt to understand more about pathogenesis malignant potential disease. Methods Twenty patients with histologically confirmed were compared ten healthy controls through immunohistochemical analysis levels p53, p63, bcl-2, Ki-67 COX-2. Results The results demonstrated significantly decreased p63 normal oral mucosa. Ki-67, COX-2 not different from those control group. A significant association was found between ( p = 0.001), well p53 0.016). Expression apoptotic appeared be independent each other 0.44). intensity any five analyzed related severity clinical manifestation. Conclusions obtained suggest that apoptosis may dominant mechanism disease’s pathogenesis. Decreased on hand appears play important role. Among possible effects this protein deficiency are activation death, cycle arrest, cellular senescence, or anoikis; suppression proliferation changes differentiation. observed reduction Ki67 bcl-2 predisposes epithelial thinning, erosions and/or ulcers. For presented cohort, there no molecular evidence

Language: Английский

Citations

0