Ameliorative effect of Nyctanthes arbor-tristis L. by suppression of pentylenetetrazole-induced kindling in mice: An insight from EEG, neurobehavioral and in-silico studies DOI Open Access

Usman Javaid,

Syeda Afroz, Waseem Ashraf

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116791 - 116791

Published: May 21, 2024

Epilepsy is an abiding condition associated with recurrent seizure attacks along neurological and psychological emanation owing to disparity of excitatory inhibitory neurotransmission. The current study encompasses the assessment Nyctanthes arbor-tristis L. methanolic extract (Na.Cr) in management convulsive state concomitant conditions epilepsy. latency incidence was assessed using pentylenetetrazol (PTZ) kindling models EEG Na.Cr pretreated mice, trailed by behavior (anxiety memory), biochemical assay, histopathological alterations, chemical profiling through GCMS, molecular docking. chronic PTZ-induced kindled mice depicted salvation a dose-related pattern outcomes were noticeable at 400 mg/kg. mg/kg defends progress seizures EEG. Co-morbid emanating epileptic outbreaks validated behavioral testing outcome defense related anxiety (P<0.001) cognitive deficit isolated brains evaluated for oxidative stress demonstrated effect dose-dependent pattern. Treatment Na.Cr. also preserved brain from PTZ induced neuronal damage as indicated analysis. Furthermore, GCMS predicted 28 compounds abundantly found plant. results congregated experiments deliver valued evidence about defensive response apportioned which might be due decline stress, AChE level, GABAergic modulation. These activities may contribute fundamental pharmacology elucidate some mechanisms behind arbor-tristis.

Language: Английский

Ameliorative effect of Nyctanthes arbor-tristis L. by suppression of pentylenetetrazole-induced kindling in mice: An insight from EEG, neurobehavioral and in-silico studies DOI Open Access

Usman Javaid,

Syeda Afroz, Waseem Ashraf

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 175, P. 116791 - 116791

Published: May 21, 2024

Epilepsy is an abiding condition associated with recurrent seizure attacks along neurological and psychological emanation owing to disparity of excitatory inhibitory neurotransmission. The current study encompasses the assessment Nyctanthes arbor-tristis L. methanolic extract (Na.Cr) in management convulsive state concomitant conditions epilepsy. latency incidence was assessed using pentylenetetrazol (PTZ) kindling models EEG Na.Cr pretreated mice, trailed by behavior (anxiety memory), biochemical assay, histopathological alterations, chemical profiling through GCMS, molecular docking. chronic PTZ-induced kindled mice depicted salvation a dose-related pattern outcomes were noticeable at 400 mg/kg. mg/kg defends progress seizures EEG. Co-morbid emanating epileptic outbreaks validated behavioral testing outcome defense related anxiety (P<0.001) cognitive deficit isolated brains evaluated for oxidative stress demonstrated effect dose-dependent pattern. Treatment Na.Cr. also preserved brain from PTZ induced neuronal damage as indicated analysis. Furthermore, GCMS predicted 28 compounds abundantly found plant. results congregated experiments deliver valued evidence about defensive response apportioned which might be due decline stress, AChE level, GABAergic modulation. These activities may contribute fundamental pharmacology elucidate some mechanisms behind arbor-tristis.

Language: Английский

Citations

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