FDA-Approved Antibacterials and Echinocandins

Antibiotics, Journal Year: 2025, Volume and Issue: 14(2), P. 166 - 166

Published: Feb. 7, 2025

Since 1955, a total of 12 peptide-based drugs with antimicrobial or antifungal properties have received approval from the Food and Drug Administration (FDA). Peptides present promising opportunity to address serious infections that may be challenging manage through other means. exhibit capability leverage various mechanisms, in some cases, multiple mechanisms are employed for this purpose. Despite initial dating back FDA recently approved an echinocandin peptide just last year. The ongoing approvals underscore significance peptides addressing medical challenges. Approximately 22 therapeutics antibacterial spectrum currently undergoing phases clinical trials, showing results. In review, analyzed terms their chemical structure, indication, mode action, development journey, concluding arrival pharmaceutical market.

Language: Английский

Lasso peptides: A focus on therapeutic index

World Journal of Microbiology and Biotechnology, Journal Year: 2025, Volume and Issue: 41(5)

Published: April 28, 2025

Language: Английский