The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Emerging role of environmental pollutants in inflammatory bowel disease risk, outcomes and underlying mechanisms DOI
María Manuela Estevinho, Vishal Midya, Shirley Cohen‐Mekelburg

et al.

Gut, Journal Year: 2024, Volume and Issue: unknown, P. gutjnl - 332523

Published: Aug. 23, 2024

Epidemiological and translational data increasingly implicate environmental pollutants in inflammatory bowel disease (IBD). Indeed, the global incidence of IBD has been rising, particularly developing countries, parallel with increased use chemicals synthetic materials daily life escalating pollution levels. Recent nationwide ecological studies have reported associations between agricultural pesticides IBD, Crohn’s disease. Exposure to other chemical categories also linked an risk IBD. To synthesise available identify knowledge gaps, we conducted a systematic review human that on impact outcomes. Furthermore, summarised vitro animal investigating mechanisms underlying these associations. The 32 included corroborate heavy transition metals, except zinc, air pollutants, per- polyfluorinated substances, are associated exposure being disease-related adverse outcomes as well. narrative preclinical suggests several overlapping associations, including intestinal permeability, systemic inflammation dysbiosis. A consolidated understanding exposures is key identification potentially modifiable factors inform strategies towards prediction, prevention mitigation

Language: Английский

Citations

10
Fenpropathrin disrupted the gills of common carp (Cyprinus carpio L.) through oxidative stress, inflammatory responses, apoptosis, and transcriptional alterations DOI Creative Commons
Wenhua Wang,

Shaoyu Mou,

Wenyao Xiu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 271, P. 116007 - 116007

Published: Jan. 26, 2024

Fenpropathrin (FEN) is an extensively utilized synthetic pyrethroid insecticide frequently found in aquatic ecosystems. However, the adverse effects and potential mechanisms of FEN on species are poorly understood. In this work, common carp were treated with at concentrations 0.45 1.35 μg/L for 14 days, after which tissue structure, physiological alterations, mRNA transcriptome gills evaluated. Specifically, exposure caused pathological damage to carp, downregulated levels claudin-1, occludin, zonula occluden-1 (ZO-1), inhibited Na

Language: Английский

Citations

6
Effect of microcystin-LR on intestinal microbiota, metabolism, and health of zebrafish (Danio rerio) DOI
Yiyi Feng, Liuying Li, Qingping Ma

et al.

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178838 - 178838

Published: Feb. 12, 2025

Language: Английский

Citations

0
Toxicological effects of chemical pesticides in fish: Focusing on intestinal injury and gut microbial dysbiosis DOI
Bizhang Dong,

Hyo-Bang Moon

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 211, P. 106405 - 106405

Published: April 9, 2025

Language: Английский

Citations

0
Revelation of benzo(a)pyrene-induced latent toxicity mechanism to intestinal histomorphology and oxidative status for common carp (Cyprinus carpio) through transcriptional and single-cell sequencing DOI

Qirui Hao,

Zhongxiang Chen, Ze Fan

et al.

Aquaculture, Journal Year: 2024, Volume and Issue: 585, P. 740712 - 740712

Published: Feb. 24, 2024

Language: Английский

Citations

2
Risk Assessment of Fenpropathrin: Cause Hepatotoxicity and Nephrotoxicity in Common Carp (Cyprinus carpio L.) DOI Open Access

Gongming Zhu,

Zhihui Liu, Hao Wang

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9822 - 9822

Published: Sept. 11, 2024

The synthetic pyrethroid pesticide fenpropathrin (FEN) is extensively used worldwide and has frequently been detected in biota the environment, whilst negative effects toxicological mechanisms of FEN on non-target organisms are still unknown. In present study, healthy immature common carp were treated with (0.45 1.35 μg/L) for a duration 14 days, impacts possible fish investigated. Biochemical analyses results showed that exposure altered levels glucose (GLU), total cholesterol (T-CHO), triglyceride (TG), albumin (ALB), alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate (AST) serum, caused histological injury liver kidney, indicating may cause hepatotoxicity nephrotoxicity carp. addition, also activities superoxide dismutase (SOD) catalase (CAT) upregulated reactive oxygen species (ROS), elevated malondialdehyde (MDA) kidney. Meanwhile, tumor necrosis factor-α (TNF-α) interleukin-1β (IL-1β) upregulated, oxidative stress inflammatory reaction be involved by FEN. Furthermore, RNA-seq analysis revealed treatment induced diverse array transcriptional changes kidney downregulated differentially expressed genes (DEGs) concentrated multiple pathways, especially cell cycle DNA replication, suggesting induce arrest hepatocytes renal cells, subsequently inducing nephrotoxicity. Overall, study enhances our comprehension toxic provides empirical evidence to support risk assessment organisms.

Language: Английский

Citations

2
Investigating the role of the ROS/CncC-xenobiotics signaling pathway in the response to Fenpropathrin in Cyprinus carpio lymphocytes: Involving lipid peroxidation and Fe2+ metabolism imbalance DOI
Lei Diao, Jing Gao, Yuxun Zhou

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 205, P. 106142 - 106142

Published: Sept. 19, 2024

Language: Английский

Citations

1
Developmental effects of fenpropathrin on zebrafish (Danio rerio) embryo-larvae: Toxic endpoints and potential mechanism DOI
Junguo Ma,

Chunyu Diao,

Yidan Zhang

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2024, Volume and Issue: 208, P. 106262 - 106262

Published: Dec. 17, 2024

Language: Английский

Citations

1
Effect of dietary vitamin D3 on growth performance and functional homeostasis of particular intestinal segments in grass carp fingerlings DOI

Hao Sun,

Pei Ge, Jiaxi Liu

et al.

Aquaculture International, Journal Year: 2024, Volume and Issue: 32(5), P. 5677 - 5697

Published: Feb. 27, 2024

Language: Английский

Citations

0
The mechanistic pathway induced by fenpropathrin toxicity: Oxidative stress, signaling pathway, and mitochondrial damage DOI
Soliman Mm, Adel F. Tohamy, Abdelbary Prince

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2024, Volume and Issue: 38(11)

Published: Oct. 17, 2024

Abstract Fenpropathrin (FNP) is a kind of insecticide and acaricide known as pyrethroid. It very effective, has wide range activities, works quickly. Internationally, it commonly considered the most powerful pyrethroid insecticide. Nevertheless, an increasing amount data indicates substantial link between adverse effects on nontarget species, including liver toxicity, kidney nerve damage, reproductive toxicity. Oxidative stress plays vital role in toxicity fenpropathrin, addition to its mechanical mechanism. This study offers thorough examination harmful oxidative mitochondrial processes, well signaling pathways involved these effects. The significant impact emphasizes Fenpropathrin.

Language: Английский

Citations

0