Intravenous Indoxacarb Toxicity: A Rare Case of Unusual Exposure with Clinical Implications DOI Creative Commons

Hamidreza Farhadi Rad,

Maryam Shahrokhi, Habibeh Mashayekhi‐Sardoo

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: unknown, P. 101876 - 101876

Published: Dec. 1, 2024

Language: Английский

A Comprehensive Review of Nanoparticle-Based Drug Delivery for Modulating PI3K/AKT/mTOR-Mediated Autophagy in Cancer DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Sujay Kumar Bhajan

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(5), P. 1868 - 1868

Published: Feb. 21, 2025

The phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of the rapamycin (mTOR) pathway plays a crucial role in regulation autophagy, cellular mechanism vital for homeostasis through degradation damaged organelles and proteins. dysregulation this is significantly associated with cancer progression, metastasis, resistance to therapy. Targeting PI3K/AKT/mTOR signaling presents promising strategy treatment; however, traditional therapeutics frequently encounter issues related nonspecific distribution systemic toxicity. Nanoparticle-based drug delivery systems represent significant advancement addressing these limitations. Nanoparticles enhance bioavailability, stability, targeted therapeutic agents, facilitating precise modulation autophagy cells. Functionalized nanoparticles, such as liposomes, polymeric metal-based nanocarriers, facilitate tumor tissues, minimizing off-target effects improving efficacy. These can deliver multiple agents concurrently, enhancing PI3K/AKT/mTOR-mediated oncogenic pathways. This review examines advancements nanoparticle-mediated that pathway, emphasizing their contribution precision side integration nanotechnology molecularly therapies substantial potential resistance. Future initiatives must prioritize optimization clinical translation patient outcomes.

Language: Английский

Citations

1
Design, Synthesis, Antibacterial Activity, and Antivirulence Factor of Novel 1,2,4-Thiadiazole Derivatives Containing an Amide Moiety DOI
Yong Zhang, Mei Zhu, Xiaoyan Zhao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: 73(9), P. 5150 - 5162

Published: Feb. 18, 2025

To develop antibacterial agents with novel mechanisms of action, a series 1,2,4-thiadiazole derivatives containing amide structures were designed and synthesized. The activities against Xanthomonas oryzae pv. oryzicola (Xoc), (Xoo), Pseudomonas syringae actinidiae (Psa) evaluated, all exhibited excellent activities. Among them, compound Z4 demonstrated significant Xoo, Xoc, Psa, EC50 values 0.32, 0.43, 11.06 mg/L, respectively. Compound protective activity 49.42% curative 44.93% rice bacterial leaf blight. In addition, could inhibit pathogenic bacteria by inhibiting variety virulence factors (exopolysaccharides, biofilms, motility, extracellular enzymes). stimulated the biochemical process self-defense signaling affecting cell transcription translation induced genes controlled hypersensitivity reactions to resist pathogen infection.

Language: Английский

Citations

0
Sublethal indoxacarb exposure alters pheromone production and ovarian development in the yellow peach moth, Conogethes punctiferalis DOI
Yunhui Zhang, Yao Zhang, Zhen Li

et al.

Pesticide Biochemistry and Physiology, Journal Year: 2025, Volume and Issue: 210, P. 106368 - 106368

Published: March 9, 2025

Language: Английский

Citations

0
Lower toxicity of HFPO-DA compared to its predecessor PFOA to the earthworm Eisenia fetida: Evidence from oxidative stress and transcriptomic analysis DOI

Ruolin Wu,

Xiaole Wang, Jingwen Zhang

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 486, P. 137003 - 137003

Published: Dec. 24, 2024

Language: Английский

Citations

2
PDCD4 Inhibition Alleviates Neuropathic Pain by regulating Spinal Autophagy and neuroinflammation DOI Creative Commons
Ting Zhang,

Le Qi,

Kai Sun

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: June 26, 2024

Abstract Neuropathic pain is still a clinical challenge. Inflammatory responses and autophagy in the spinal cord are important mechanisms for occurrence maintain of neuropathic pain. PDCD4 an molecule that regulates inflammatory autophagy. However, regulatory role unknown modulation. In this study we found expression CCI mice was increased. Inhibition by intrathecal injection adeno-associated virus alleviated enhanced mice, inhibited activation MAPK pathway glia, as well factors. Intrathecal inhibitor 3-MA reversed inhibition induced relief change Our results indicate alleviates sensitization may be developed into therapeutic target.

Language: Английский

Citations

0
Sulfone derivatives containing an oxazole moiety as potential antibacterial agents: design, synthesis, antibacterial activity, and mechanism DOI
Yong Zhang, Mei Zhu,

Zongnan Zhu

et al.

Pest Management Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract BACKGROUND Bacterial diseases in plants pose a serious threat to crop production, leading substantial food loss every year. Prolonged and repeated use of single antibacterial agent can promote resistance pathogenic bacteria. Therefore, there is an urgent need develop efficient agents for the treatment bacterial diseases. RESULTS Sulfone derivatives containing oxazole moiety were designed synthesized. Subsequently, their biological activities evaluated. The half‐maximal effective concentration (EC 50 ) value compound F10 against Xanthomonas oryzae pv. oryzicola ( Xoc was 1.1 mg/L, which higher than those commercial agents, thiodiazole‐copper (91.5 mg/L) bismerthiazol (76.0 mg/L). curative protective effects leaf streak rice 43.8% 48.4%, respectively, at 200 significantly superior (25.0% 25.8%, respectively) (31.3% 38.7%, respectively). Compound inhibits by increasing permeability cell membrane, inhibiting production extracellular polysaccharides, affecting flagellar movement on membrane. In addition, reduces pathogenicity bacteria, induces accumulation reactive oxygen species (ROS) produces adverse reactions. weakens signal transduction plant hormones, programmed death, enhancing ability resist infection through autoimmune response rice. CONCLUSION be used as potential future applications. © 2024 Society Chemical Industry.

Language: Английский

Citations

0
pH/Enzyme-responsive nanocarrier pesticide delivery system: Realizing targeted release in pest gut for enhanced Apis cerana safety DOI

Pengrui Du,

Xuehua Shao, Hao Wu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 503, P. 158419 - 158419

Published: Dec. 8, 2024

Language: Английский

Citations

0
Intravenous Indoxacarb Toxicity: A Rare Case of Unusual Exposure with Clinical Implications DOI Creative Commons

Hamidreza Farhadi Rad,

Maryam Shahrokhi, Habibeh Mashayekhi‐Sardoo

et al.

Toxicology Reports, Journal Year: 2024, Volume and Issue: unknown, P. 101876 - 101876

Published: Dec. 1, 2024

Language: Английский

Citations

0