Anxiety treatment: Updated options DOI Creative Commons
Yury P. Sivolap, Anna A. Portnova

Meditsinskiy sovet = Medical Council, Journal Year: 2025, Volume and Issue: 3, P. 111 - 116

Published: April 12, 2025

Generalized anxiety disorder and other spectrum disorders constitute the category of most common mental disorders. Three lines pharmacological therapy are used in treatment disorders: 1) selective serotonin reuptake inhibitors (SSRI) norepinephrine (SNRI); 2) benzodiazepines; 3) antipsychotics. Along with SSRI SNRI, groups antidepressants disorders, drugs anxiolytic properties, such as pregabalin, being considered alternatives to benzodiazepines. Drugs each three categories characterized by both advantages disadvantages that limit their clinical use, which determines need find new treatments for One modern promising generalized is Aviandr, was designated AVN-101 CD-008-0045 at stages development initial testing. The efficacy safety Aviandr has been proven results randomized controlled trials; addition, effectiveness drug improving condition patients who have suffered from acute coronavirus infection noted. In addition its effect, shows ability reduce depressive symptoms exhibits a number additional effects. A notable feature gives it over traditional comparable effectiveness, absence daytime sleepiness, often occurs when benzodiazepines prescribed, side effects typical SSRI.

Language: Английский

Novel Thyroid Hormone Receptor-β Agonist TG68 Exerts Anti-Inflammatory, Lipid-Lowering and Anxiolytic Effects in a High-Fat Diet (HFD) Mouse Model of Obesity DOI Creative Commons
Beatrice Polini,

Caterina Ricardi,

F. Di Lupo

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 580 - 580

Published: April 11, 2025

Recent advances in drug development allowed for the identification of THRβ-selective thyromimetic TG68 as a very promising lipid lowering and anti-amyloid agent. In current study, we first investigated neuroprotective effects on vitro human models neuroinflammation β-amyloid neurotoxicity order to expand our knowledge therapeutic potential this novel thyromimetic. Subsequently, examined metabolic inflammatory profiles, along with cognitive changes, using high-fat diet (HFD) mouse model obesity. Our data demonstrated that was able prevent either LPS/TNFα-induced response or β-amyloid-induced cytotoxicity microglial (HMC3) cells. Next, HFD-fed mice, treatment (10 mg/kg/day; 2 weeks) significantly reduced anxiety-like behavior stretch–attend posture (SAP) tests while producing 12% BW loss significant decrease blood glucose levels. Notably, these highlight close relationship between improved serum parameters reduction anxious behavior. Moreover, administration observed efficiently counteract HFD-altered central peripheral expressions mice selected biomarkers dysfunction, inflammation, neurotoxicity, revealing effects. conclusion, work provides preliminary evidence may represent opportunity interlinked diseases such obesity neurodegenerative diseases.

Language: Английский

Citations

0
Anxiety treatment: Updated options DOI Creative Commons
Yury P. Sivolap, Anna A. Portnova

Meditsinskiy sovet = Medical Council, Journal Year: 2025, Volume and Issue: 3, P. 111 - 116

Published: April 12, 2025

Generalized anxiety disorder and other spectrum disorders constitute the category of most common mental disorders. Three lines pharmacological therapy are used in treatment disorders: 1) selective serotonin reuptake inhibitors (SSRI) norepinephrine (SNRI); 2) benzodiazepines; 3) antipsychotics. Along with SSRI SNRI, groups antidepressants disorders, drugs anxiolytic properties, such as pregabalin, being considered alternatives to benzodiazepines. Drugs each three categories characterized by both advantages disadvantages that limit their clinical use, which determines need find new treatments for One modern promising generalized is Aviandr, was designated AVN-101 CD-008-0045 at stages development initial testing. The efficacy safety Aviandr has been proven results randomized controlled trials; addition, effectiveness drug improving condition patients who have suffered from acute coronavirus infection noted. In addition its effect, shows ability reduce depressive symptoms exhibits a number additional effects. A notable feature gives it over traditional comparable effectiveness, absence daytime sleepiness, often occurs when benzodiazepines prescribed, side effects typical SSRI.

Language: Английский

Citations

0