The Pharmacological Efficacy of Baicalin in Inflammatory Diseases

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(11), P. 9317 - 9317

Published: May 26, 2023

Baicalin is one of the most abundant flavonoids found in dried roots Scutellaria baicalensis Georgi (SBG) belonging to genus Scutellaria. While baicalin demonstrated have anti-inflammatory, antiviral, antitumor, antibacterial, anticonvulsant, antioxidant, hepatoprotective, and neuroprotective effects, its low hydrophilicity lipophilicity limit bioavailability pharmacological functions. Therefore, an in-depth study baicalin’s pharmacokinetics contributes laying theoretical foundation for applied research disease treatment. In this view, physicochemical properties anti-inflammatory activity are summarized terms bioavailability, drug interaction, inflammatory conditions.

Language: Английский

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Macrofungi: A review of cultivation strategies, bioactivity, and application of mushrooms

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2020, Volume and Issue: 19(5), P. 2333 - 2356

Published: July 15, 2020

Abstract The production of macrofungi (mushrooms) as well their economic value have been steadily increasing globally. use functional foods, dietary supplements, and traditional medicines derived from is they numerous health benefits abundant nutrients. Macrofungi are diverse with complex highly varied growth conditions bioactive constituents, most macrofungal resources not yet fully explored applicated, leading to an urgent need for appropriate strategies address the problem. Increasing attention has paid cultivation application, in particular, potential prebiotics. Herein, present review comprehensively summarizes recent progress cultivation, newly identified effects on gut microbiota ways which affect human health. Moreover, food development discussed improve nutritional change quality characteristics food. Finally, addresses consumer safety concerns prospective genetic manipulation macrofungi. We hope that this can provide a comprehensive research reference ensuring efficacy, along maximizing profitability production.

Language: Английский

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Comprehensive utilization of Chinese medicine residues for industry and environment protection: Turning waste into treasure

Journal of Cleaner Production, Journal Year: 2020, Volume and Issue: 279, P. 123856 - 123856

Published: Aug. 22, 2020

Language: Английский

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The interaction between the gut Microbiota and herbal medicines

Biomedicine & Pharmacotherapy, Journal Year: 2019, Volume and Issue: 118, P. 109252 - 109252

Published: Aug. 23, 2019

As technologies used to study the gut microbiota have improved, relationship between and health has become increasingly obvious. Herbal medicines been for thousands of years, are known be "simple, convenient, cheap, effective". However, due many factors, such as their complex composition, unclear active compounds, poor knowledge underlying mechanisms, clinical applications herbal not widely recognized. Recently, there an increasing number studies which investigated interaction medicines. We found that interactions occur primarily through two pathways. One pathway is "digests" into absorbable small molecules, enter body induce physiological changes. The other regulate composition its secretions, thereby changed secretions inducing In summary, can attributed molecules secretions. Our findings will aid exploration mechanisms pathways function in future. This review also summarizes direction future research main problems faced by current researchers.

Language: Английский

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Knowledge Domain and Emerging Trends in Vinegar Research: A Bibliometric Review of the Literature from WoSCC

Foods, Journal Year: 2020, Volume and Issue: 9(2), P. 166 - 166

Published: Feb. 10, 2020

Vinegar is one of the most widely used acidic condiments. In recent decades, rapid advances have been made in area vinegar research, and intellectual structure pertaining to this domain has significantly evolved. Thus, it important that scientists keep abreast associated developments ensure an appropriate understanding field. To facilitate current study, a bibliometric analysis method was adopted visualize knowledge map research based on literature data retrieved from Web Science Core Collection (WoSCC) database. total, 883 original review articles between 1998 2019 with 19,663 references were analyzed by CiteSpace. Both macroscopical sketch microscopical characterization whole realized. According contents, main themes underlie can be divided into six categories, is, microorganisms, substances, health functions, production technologies, adjuvant medicines, residues. addition latter analysis, emerging trends future foci predicted. Finally, evolutionary stage discerned according Shneider’s four-stage theory. This will help discern dynamic evolution as well highlight areas for research.

Language: Английский

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Role of gut microbiota in identification of novel TCM-derived active metabolites

Protein & Cell, Journal Year: 2020, Volume and Issue: 12(5), P. 394 - 410

Published: Sept. 15, 2020

Traditional Chinese Medicine (TCM) has been extensively used to ameliorate diseases in Asia for over thousands of years. However, owing a lack formal scientific validation, the absence information regarding mechanisms underlying TCMs restricts their application. After oral administration, TCM herbal ingredients frequently are not directly absorbed by host, but rather enter intestine be transformed gut microbiota. The microbiota is microbial community living animal intestines, and functions maintain host homeostasis health. Increasing evidences indicate that herbs closely affect composition, which associated with conversion components into active metabolites. These may significantly therapeutic activity TCMs. Microbiota analyses, conjunction modern multiomics platforms, can together identify novel functional metabolites form basis future research.

Language: Английский

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Panax ginseng and its ginsenosides: potential candidates for the prevention and treatment of chemotherapy-induced side effects

Journal of Ginseng Research, Journal Year: 2021, Volume and Issue: 45(6), P. 617 - 630

Published: March 6, 2021

Chemotherapy-induced side effects affect the quality of life and efficacy treatment cancer patients. Current approaches for treating chemotherapy are poorly effective may cause numerous harmful effects. Therefore, developing new drugs derived from natural non-toxic compounds chemotherapy-induced is necessary. Experiments in vivo vitro indicate that Panax ginseng (PG) its ginsenosides undoubtedly options effects, such as nephrotoxicity, hepatotoxicity, cardiotoxicity, immunotoxicity, hematopoietic inhibition. The mechanism focus on anti-oxidation, anti-inflammation, anti-apoptosis, well modulation signaling pathways, nuclear factor erythroid-2 related 2 (Nrf2)/heme oxygenase-1 (HO-1), P62/keap1/Nrf2, c-jun N-terminal kinase (JNK)/P53/caspase 3, mitogen-activated protein (MEK)/extracellular signal-regulated kinases (ERK), AMP-activated (AMPK)/mammalian target rapamycin (mTOR), 4 (MKK4)/JNK, phosphatidylinositol 3-kinase (PI3K)/AKT. Since a systemic review effect PG has not yet been published, we provide comprehensive summarization with this aim shed light future research PG.

Language: Английский

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Health benefits and limitations of rutin - A natural flavonoid with high nutraceutical value

Phytochemistry Letters, Journal Year: 2021, Volume and Issue: 46, P. 119 - 128

Published: Oct. 15, 2021

Language: Английский

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A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

Acta Pharmaceutica Sinica B, Journal Year: 2021, Volume and Issue: 11(6), P. 1379 - 1399

Published: March 21, 2021

Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems biology and its various data integration approaches to promote modernization. Thus, integrative pharmacology-based (TCMIP) was proposed as a paradigm shift in TCM. This review focuses on presentation of this novel concept main research contents, methodologies applications TCMIP. First, TCMIP is an interdisciplinary science that can establish qualitative quantitative pharmacokinetics–pharmacodynamics (PK–PD) correlations through knowledge from multiple disciplines techniques different PK–PD processes vivo. Then, contents are introduced follows: chemical ADME/PK profiles TCM formulas; confirming three forms active substances action modes; establishing correlation; building correlations, etc. After that, we summarize existing resources, computational models experimental methods highlight urgent establishment mathematical modeling methods. Finally, further discuss for improvement quality control, clarification molecular mechanisms underlying actions TCMs discovery potential new drugs, especially TCM-related combination drug discovery.

Language: Английский

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A Review of the Pharmacological Properties of Psoralen

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Sept. 4, 2020

Psoralen is the principal bioactive component in dried fruits of Psoralea corylifolia L. termed "Buguzhi" traditional Chinese medicine(TCM). Recent studies have demonstrated that psoralen displays multiple properties, beneficial for treatment osteoporosis, tumors, viruses, bacteria, and inflammation. The present review focuses on research evidence relating to properties gathered over recent years. Firstly, exerts strong anti-osteoporotic effects via regulation osteoblast/osteoclast/chondrocyte differentiation or activation due participation molecular mechanisms wnt/β-catenin, bone morphogenetic protein (BMP), inositol-requiring enzyme 1 (IRE1) / apoptosis signaling kinase (ASK1)/ c-jun N-terminal (JNK) Protein Kinase B(AKT) activator protein-1 (AP-1) axis, expression miR-488, peroxisome proliferators-activated receptor-gamma (PPARγ), matrix metalloproteinases (MMPs). In addition, antitumor are associated with induction ER stress-related cell death enhancement PERK: Pancreatic Endoplasmic Reticulum (PERK)/activating transcription factor (ATF), glucose-regulated 78 (GRP78) C/EBP homologous (CHOP) 94 (GRP94)/CHOP signaling, inhibition P-glycoprotein (P-gp) ATPase overcomes multidrug resistance. Furthermore, articles shown antibacterial, anti-inflammatory neuroprotective a result its interaction viral polymerase (Pol), destroying formation biofilm, regulating tumor necrosis alpha (TNF-α), transforming growth beta (TGF-β), interleukin 4/5/6/8/12/13 (IL-4/5/6/8/12/13), GATA-3, acetylcholinesterase (AChE), hypothalamic-pituitary-adrenal (HPA) axis. Finally, toxic action also been reviewed.

Language: Английский

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