Recent advances in drug discovery efforts targeting the sigma 1 receptor system: Implications for novel medications designed to reduce excessive drug and food seeking

Addiction Neuroscience, Journal Year: 2023, Volume and Issue: 8, P. 100126 - 100126

Published: Aug. 27, 2023

Psychiatric disorders characterized by uncontrolled reward seeking, such as substance use (SUDs), alcohol disorder (AUD) and eating disorders, impose a significant burden on individuals society. Despite their high prevalence substantial morbidity mortality rates, treatment options for these remain limited. Over the past two decades, there has been gradual accumulation of evidence pointing to sigma-1 receptor (S1R) system promising target therapeutic interventions designed treat diseases. S1R is chaperone protein that resides in endoplasmic reticulum, but under certain conditions translocates plasma membrane. In brain, S1Rs are expressed several regions important reward, following translocation, they physically associate with reward-related GPCRs, including dopamine receptors 1 2 (D1R D2R). Psychostimulants, alcohol, well palatable foods, all alter expression motivated behavior, antagonists generally decrease behavioral responses rewards. Recent advances structural modeling have permitted development highly-selective favorable pharmacokinetic profiles, thus providing avenue S1R-based medications. Here, we provide an up-to-date overview work linking behavior drugs abuse food, supporting clinical utility reduce excessive consumption. We also highlight potential challenges associated targeting system, need more comprehensive understanding underlying neurobiology careful consideration pharmacological properties drugs.

Language: Английский

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Binge eating disorder symptomatology and its association with depression, anxiety and stress: a cross-sectional study in medical students/Sintomatología del trastorno por atracón y su asociación con depresión, ansiedad y estrés: estudio transversal en estudiantes de Medicina

Revista Mexicana de Trastornos Alimentarios/Mexican Journal of Eating Disorders, Journal Year: 2024, Volume and Issue: 14(1), P. 53 - 64

Published: Jan. 2, 2024

Language: Английский

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Synthesis and biological evaluation of novel 18F-labeled 2,4-diaminopyrimidine derivatives for detection of ghrelin receptor in the brain

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 99, P. 129625 - 129625

Published: Jan. 21, 2024

Language: Английский

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Early life exposure to secondhand tobacco smoke and eating behaviors at age 12 years

Environmental Health, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 13, 2024

Prenatal or early childhood secondhand tobacco smoke (SHS) exposure increases obesity risk. However, the potential mechanisms underlying this association are unclear, but obesogenic eating behaviors one pathway that components of SHS could perturb. Our aim was to assess associations prenatal and with adolescent behaviors. Data came from a prospective pregnancy birth cohort (N = 207, Cincinnati, OH). With multiple informant models, we estimated (mean 16 26 weeks gestation maternal serum cotinine concentrations) (average concentration across ages 12, 24, 36, 48 months) at age 12 years (Child Eating Behaviors Questionnaire). We tested whether differed by periods adolescent's sex. Models adjusted for child covariates. found no statistically significant between measures Yet, in females, associated greater food responsiveness (β: 0.23; 95% CI: 0.08, 0.38) lower satiety -0.14; -0.26, -0.02); males, postnatal related (prenatal: β: -0.25; -0.04, -0.06; postnatal: -0.36; -0.06, -0.11). No effect modification sex window other exposures were not behavior cohort; however, biological may modify these associations.

Language: Английский

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Faim et satiété, contrôle comportemental de la prise alimentaire

EMC - Endocrinologie - Nutrition, Journal Year: 2024, Volume and Issue: 35(2), P. 1 - 6

Published: April 1, 2024

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