In Silico and Therapeutic Efficacy of Glycyrrhizin‐Based Silver Nanoparticles Against Bacteria Related to Periodontitis DOI Open Access
Ritu Mahanty, Debasmita Dubey,

Deepak Pradhan

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(1)

Published: Jan. 1, 2025

Abstract Rising antibiotic resistance among periodontal pathogens poses a major challenge to treatment outcomes. This work investigates the possible combinatorial potential of AgNPs synthesized using glycyrrhizin, natural biosurfactant, combat biofilm‐forming bacteria isolated from periodontitis patients. In silico findings revealed that glycyrrhizin had higher binding affinity score ‐9.102 compared doxycycline (−3.599) for gtfB , plays an indispensable function in biofilm integrity. were and optimized utilizing design experiments, considering factors such as pH, temperature, incubation time concentration variables. while The resulting GL‐AgNPs characterized by different analytical techniques FTIR, XRD, DLS, SEM. nanoparticles non‐spherical, uniform average size 72 nm, zeta potentials ranged −28 mV − 42 mV. Antimicrobial suggested exhibited significant antibacterial anti‐biofilm activity prepared sodium borohydride ( p < 0.001). Experimental inhibited formation attenuating Gtfase activity. Further, show effective anti‐inflammatory with minimal cytotoxicity. Overall, this study highlights inherent antimicrobial surfactant properties greatly improve AgNPs, providing promising approach combating biofilm‐producing oral periodontitis.

Language: Английский

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator DOI Creative Commons
Zhu Zhang, Ken Kin Lam Yung, Joshua Ka-Shun Ko

et al.

Antioxidants, Journal Year: 2022, Volume and Issue: 11(7), P. 1349 - 1349

Published: July 11, 2022

Oxidative stress could lead to a variety of body dysfunctions, including neurodegeneration and cancer, which are closely associated with intracellular signal transducers such as reactive oxygen species (ROS). It has been suggested that ROS is the upstream regulator autophagy, it provides negative feedback regulation remove oxidative damage. Defects in ROS-autophagic redox homeostasis increased production accumulation damaged organelles turn promote metabolic reprogramming induce tumorigenesis. One significant characteristic pancreatic cancer cellular energy metabolism, facilitates rapid growth, invasiveness, survival cells. Thus, rectification dysfunction essential therapeutic targeting. Isoliquiritigenin (ISL) chalcone obtained from plant Glycyrrhiza glabra, powdered root licorice consumed for centuries different regions world. ISL known be natural antioxidant possesses diversified functions, This review contains discussions on herbal source, biological properties, anticancer potential ISL. first time activities elucidated, coverage involvement antioxidation, regulation, autophagy development. Furthermore, some remarks related compounds isoflavonoid biosynthetic pathway will also discussed.

Language: Английский

Citations

40
Glycyrrhetinic acid suppresses breast cancer metastasis by inhibiting M2-like macrophage polarization via activating JNK1/2 signaling DOI
Yanfen Cheng,

Xuemei Zhong,

Xin Nie

et al.

Phytomedicine, Journal Year: 2023, Volume and Issue: 114, P. 154757 - 154757

Published: March 12, 2023

Language: Английский

Citations

35
A Comprehensive Review of Licorice: The Preparation, Chemical Composition, Bioactivities and Its Applications DOI
Xiaoyu Ji, Ning Liu, Shucheng Huang

et al.

The American Journal of Chinese Medicine, Journal Year: 2024, Volume and Issue: 52(03), P. 667 - 716

Published: Jan. 1, 2024

Licorice (Glycyrrhiza) is a medicinal and food homologue of perennial plants derived from the dried roots rhizomes genus Glycyrrhiza in legume family. In recent years, comprehensive utilization licorice resources has attracted people’s attention. It widely utilized to treat diseases, health products, production, other industrial applications. Furthermore, numerous bioactive components are found using advanced extraction processes, which mainly include polyphenols (flavonoids, dihydrostilbenes, benzofurans, coumarin), triterpenoids, polysaccharides, alkaloids, volatile oils, all have been reported possess variety pharmacological characteristics, including anti-oxidant, anti-inflammatory, antibacterial, antiviral, anticancer, neuroprotective, antidepressive, antidiabetic, antiparasitic, antisex hormone, skin effects, anticariogenic, antitussive, expectorant activities. Thereby, these compounds promote development novel more effective licorice-derived products. This paper reviews progress research on techniques, chemical composition, bioactivities, applications provide reference for further application different areas.

Language: Английский

Citations

14
Advancements and challenges in pharmacokinetic and pharmacodynamic research on the traditional Chinese medicine saponins: a comprehensive review DOI Creative Commons

Yuhan Ma,

Yongxia Zhao,

Mingxia Luo

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: May 7, 2024

Recent research on traditional Chinese medicine (TCM) saponin pharmacokinetics has revealed transformative breakthroughs and challenges. The multicomponent nature of TCM makes it difficult to select representative indicators for pharmacokinetic studies. clinical application saponins is limited by their low bioavailability short half-life, resulting in fluctuating plasma concentrations. Future directions should focus novel compounds utilizing colon-specific delivery osmotic pump systems enhance oral bioavailability. Optimizing drug combinations, such as ginsenosides with aspirin, shows therapeutic potential. Rigorous validation essential practical applications. This review emphasizes a era research, highlighting the need validation. pharmacokinetics, guided principles, are development, multidisciplinary approaches comprehensive understanding. provides theoretical basis new drugs supports rational medication.

Language: Английский

Citations

8
Three-dimensional fluorescence combined with alternating trilinear decomposition and random forest algorithm for the rapid prediction of species, geographical origin and main components of Glycyrrhizae Radix et Rhizoma (Gancao) DOI
Hengye Chen,

Lixue Ren,

Yinan Yang

et al.

Food Chemistry, Journal Year: 2024, Volume and Issue: 444, P. 138603 - 138603

Published: Feb. 1, 2024

Language: Английский

Citations

7
Recent advancements in natural compounds for cancer therapy and prevention DOI

R. Pavithra,

Mohammad Rashid Khan, Mohd Shahanbaj Khan

et al.

Phytochemistry Reviews, Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Language: Английский

Citations

7
Protective Effects of Isoliquiritigenin and Licochalcone B on the Immunotoxicity of BDE-47: Antioxidant Effects Based on the Activation of the Nrf2 Pathway and Inhibition of the NF-κB Pathway DOI Creative Commons

Dong Minghui,

Ziying Yang, Qian Gao

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(4), P. 445 - 445

Published: April 10, 2024

2,2′,4,4′-Tetrabrominated biphenyl ether (BDE-47) is a polybrominated diphenyl (PBDE) homologue that ubiquitous in biological samples and highly toxic to humans other organisms. Prior research has confirmed BDE-47 can induce oxidative damage RAW264.7 cells, resulting apoptosis impaired immune function. The current study mainly focused on how Isoliquiritigenin (ISL) Licochalcone B (LCB) might protect against BDE-47’s immunotoxic effects cells. results show ISL LCB could increase phagocytosis, the production of MHC-II, decrease inflammatory factors (TNF-α, IL-6, IL-1β) co-stimulatory (CD40, CD80, CD86), alleviating function impairment caused by BDE-47. Secondly, both reduce expressions proteins Bax Caspase-3, promote expression protein Bcl-2, apoptotic rate, initiated Additionally, levels antioxidant substances (SOD, CAT, GSH) reactive oxygen species (ROS), thereby counteracting stress induced Ultimately, suppress NF-κB pathway down-regulating IKBKB up-regulating IκB-Alpha addition activating Nrf2 promoting HO-1 NQO1. To summarize, causes be mitigated through activation inhibition pathway, which turn prevents apoptosis. These findings enrich understanding toxicological molecular mechanism detoxification licorice.

Language: Английский

Citations

6
Protective Effects of Liquiritigenin against Cisplatin-Induced Nephrotoxicity via NRF2/SIRT3-Mediated Improvement of Mitochondrial Function DOI Creative Commons
Meng Zhou, Yanpeng Dai, Yong Ma

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(12), P. 3823 - 3823

Published: June 14, 2022

Acute kidney injury (AKI) induced by cisplatin (CP), a first-line anticancer drug for chemotherapy, is common. To date, there an urgent need to find effective treatments reduce the nephrotoxicity caused CP. Meanwhile, restoration of mitochondrial dysfunction shows potential be used as adjunct conventional therapeutic strategies. This study found that liquiritigenin can ameliorate and acute CP in mice. The intraperitoneal injection 15 mg/kg body weight 2 days markedly protected against CP-induced dysfunction, restored renal tubule morphology, decreased blood Scr BUN levels, cell apoptosis. Furthermore, elevated expression SIRT3 liquiritigenin, which upregulated NRF2, was confirmed vivo vitro. underlying protective mechanisms were then investigated. Molecular docking results showed has potent binding activities KEAP1, GSK-3β HRD1. Further nuclear translocation NRF2 increased levels bioenergetics-related protein such PGC-1α, TFAM, are related activity biogenesis. In addition, possibly reverse decrease BCL2/BAX ratio live cultured epithelial cells. Collectively, these indicated could nephroprotective agent protect cisplatin-induced NRF2-dependent manner improving mitochondria function.

Language: Английский

Citations

23
Unravelling triterpenoid biosynthesis in plants for applications in bioengineering and large-scale sustainable production DOI
Sneha Singh,

Apoorva,

Pajeb Saha

et al.

Industrial Crops and Products, Journal Year: 2023, Volume and Issue: 199, P. 116789 - 116789

Published: May 4, 2023

Language: Английский

Citations

16
Atheroprotective Effects of Glycyrrhiza glabra L. DOI Creative Commons
Yuliya V. Markina, Tatiana V. Kirichenko, Alexander M. Markin

et al.

Molecules, Journal Year: 2022, Volume and Issue: 27(15), P. 4697 - 4697

Published: July 22, 2022

Cardiovascular diseases associated with atherosclerosis are the major cause of death in developed countries. Early prevention and treatment considered to be an important aspect therapy cardiovascular disease. Preparations based on natural products affect main pathogenetic steps atherogenesis, so represent a perspective for long-term development. Numerous experimental clinical studies have demonstrated multiple beneficial effects licorice its bioactive compounds—anti-inflammatory, anti-cytokine, antioxidant, anti-atherogenic, anti-platelet action—which allow us consider as promising atheroprotective agent. In this review, we summarized current knowledge anti-atherosclerotic mechanisms action results studies, including vitro study demonstrating effect ability blood serum reduce intracellular cholesterol accumulation cultured macrophages, presented confirming ameliorating activity regard traditional risk factors well direct licorice.

Language: Английский

Citations

22