Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 444 - 444
Published: Feb. 16, 2024
Sepsis
is
a
syndrome
of
organ
dysfunction
caused
by
an
uncontrolled
inflammatory
response,
which
can
seriously
endanger
life.
Currently,
there
still
shortage
specific
therapeutic
drugs.
Quercetin
and
its
natural
derivatives
have
received
lot
attention
recently
for
their
potential
in
treating
sepsis.
Here,
we
provide
comprehensive
summary
the
recent
research
progress
on
quercetin
derivatives,
with
focus
mechanisms
antioxidation
anti-inflammation.
To
obtain
necessary
information,
conducted
search
PubMed,
Web
Science,
EBSCO,
Cochrane
library
databases
using
keywords
sepsis,
anti-inflammatory,
antioxidant,
anti-infection,
quercetin,
to
identify
relevant
from
6315
articles
published
last
five
years.
At
present,
11
been
intensively
studied.
They
primarily
exert
anti-inflammation
effects
through
PI3K/AKT/NF-κB,
Nrf2/ARE,
MAPK
pathways.
The
feasibility
these
compounds
experimental
models
clinical
application
were
also
discussed.
In
conclusion,
good
treatment
Biology,
Journal Year:
2024,
Volume and Issue:
13(9), P. 676 - 676
Published: Aug. 29, 2024
Phytochemicals
are
effective
and
gaining
attention
in
fighting
against
drug-resistant
bacterial
strains.
In
the
present
study,
rutin
quercetin
were
tested
for
antibacterial,
antibiofilm,
wound
healing
activities
on
excision
wounds
infected
with
MDR-P.
aeruginosa
diabetic
mice.
Antibacterial
antibiofilm
studied
vitro
using
broth
dilution
assay
crystal
violet
assay,
respectively.
These
phytochemicals
alone
wound-healing
at
different
concentrations
(0.5%
1%
ointment
base)
combination
gentamicin
to
evaluate
any
additive
effects.
Rutin
demonstrated
effectiveness
higher
concentrations.
Both
inhibited
biofilm
formation
contributed
of
by
eradicating
wounded
tissue.
a
low
concentration
(0.5%)
had
lesser
effect
reducing
epithelization
period
regeneration
epithelial
layer
compared
quercetin.
When
combined
gentamicin,
(1%)
displayed
maximum
epithelium
regeneration,
followed
gentamicin.
found
be
more
controlling
when
used
as
an
The
study
supports
traditional
use
managing
infections.
Arabian Journal of Chemistry,
Journal Year:
2023,
Volume and Issue:
16(10), P. 105113 - 105113
Published: July 4, 2023
The
skin
plays
a
crucial
role
in
maintaining
hydration,
preventing
dehydration,
and
protecting
against
harmful
microorganisms.
Skin
injury
can
lead
to
inflammation
fluid
loss,
which
are
detrimental
human
health.
Nanotechnology
has
been
proposed
as
potential
solution
prevent
damage
because
it
more
effectively
penetrate
the
barrier
deliver
targeted
treatments
directly
cells
that
require
them.
In
this
study,
we
biosynthesized
gold
nanoparticles
(AuNPs)
using
Isodon
excisus
(Maxim.)
Kudo
(IE)
leaf
tissue.
formation
of
IE
(IE-AuNPs)
was
confirmed
various
techniques.
Furthermore,
cytotoxicity
IE-AuNPs
on
keratinocytes
(HaCaT
cells)
evaluated,
found
had
no
cytotoxic
effect
HaCaT
(50
µg/mL).
ability
reduce
investigated
dark-field
microscopy
(DFM)
enzyme-linked
immunosorbent
assay
(ELISA).
Real-time
quantitative
reverse
transcription-polymerase
chain
reaction
(qRT-PCR)
used
assess
inflammatory
biomarkers
such
IL-6,
IL-8,
CCL17/TARC,
CCL27/CTACK,
CCL5/RANTES.
Additionally,
western
blotting
demonstrated
exhibited
anti-inflammatory
effects
by
activating
autophagy
inhibiting
PI3K/AKT
signaling
pathway
at
upstream
level.
Overall,
our
findings
suggest
enhance
be
development
nano-based
for
skin-related
diseases.
Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 444 - 444
Published: Feb. 16, 2024
Sepsis
is
a
syndrome
of
organ
dysfunction
caused
by
an
uncontrolled
inflammatory
response,
which
can
seriously
endanger
life.
Currently,
there
still
shortage
specific
therapeutic
drugs.
Quercetin
and
its
natural
derivatives
have
received
lot
attention
recently
for
their
potential
in
treating
sepsis.
Here,
we
provide
comprehensive
summary
the
recent
research
progress
on
quercetin
derivatives,
with
focus
mechanisms
antioxidation
anti-inflammation.
To
obtain
necessary
information,
conducted
search
PubMed,
Web
Science,
EBSCO,
Cochrane
library
databases
using
keywords
sepsis,
anti-inflammatory,
antioxidant,
anti-infection,
quercetin,
to
identify
relevant
from
6315
articles
published
last
five
years.
At
present,
11
been
intensively
studied.
They
primarily
exert
anti-inflammation
effects
through
PI3K/AKT/NF-κB,
Nrf2/ARE,
MAPK
pathways.
The
feasibility
these
compounds
experimental
models
clinical
application
were
also
discussed.
In
conclusion,
good
treatment
