Genes,
Journal Year:
2024,
Volume and Issue:
15(7), P. 942 - 942
Published: July 18, 2024
Diabetes
mellitus
type
2
(T2DM)
is
a
common
chronic
condition
that
presents
as
unsettled
hyperglycemia
(HG)
and
results
from
insulin
resistance
(IR)
β-cell
dysfunction.
T2DM
marked
by
an
increased
risk
of
microvascular
macrovascular
complications,
all
which
can
be
the
cause
increasing
mortality.
Diabetic
nephropathy
(DNE),
neuropathy
(DNU),
retinopathy
(DR)
are
most
complications
diabetic
microangiopathy,
while
cardiomyopathy
(DCM)
peripheral
vascular
diseases
major
macroangiopathy
complications.
Chalcones
(CHs)
in
flavonoid
family
commonly
found
certain
plant
species
intermediate
metabolites
biosynthesis
flavonoids
their
derivatives.
Natural
CHs
with
different
substituents
exert
diverse
therapeutic
activities,
including
antidiabetic
ones.
However,
mechanisms
natural
through
influencing
genes
and/or
signaling
pathways
remain
unknown.
Therefore,
this
review
summarizes
existing
experimental
models
highlight
agents
for
Journal of General Virology,
Journal Year:
2024,
Volume and Issue:
105(5)
Published: May 30, 2024
Transmissible
gastroenteritis
virus
(TGEV),
an
enteropathogenic
coronavirus,
has
caused
huge
economic
losses
to
the
pig
industry,
with
100%
mortality
in
piglets
aged
2
weeks
and
intestinal
injury
pigs
of
other
ages.
However,
there
is
still
a
shortage
safe
effective
anti-TGEV
drugs
clinics.
In
this
study,
phloretin,
naturally
occurring
dihydrochalcone
glycoside,
was
identified
as
potent
antagonist
TGEV.
Specifically,
we
found
phloretin
effectively
inhibited
TGEV
proliferation
PK-15
cells,
dose-dependently
reducing
expression
N
protein,
mRNA,
titer.
The
activity
furthermore
refined
target
internalization
replication
stages.
Moreover,
also
that
could
decrease
levels
proinflammatory
cytokines
induced
by
infection.
addition,
expanded
potential
key
targets
associated
effect
AR,
CDK2,
INS,
ESR1,
ESR2,
EGFR,
PGR,
PPARG,
PRKACA,
MAPK14
help
network
pharmacology
molecular
docking
techniques.
Furthermore,
resistant
viruses
have
been
selected
culturing
increasing
concentrations
phloretin.
Resistance
mutations
were
reproducibly
mapped
residue
(S242)
main
protease
(M
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 4, 2024
Subarachnoid
hemorrhage
(SAH),
a
stroke
subtype
associated
with
high
mortality,
is
closely
linked
to
neuroinflammation.
Phloretin,
naturally
occurring
flavonoid
abundant
in
fruits,
possesses
anti-inflammatory
properties.
However,
its
specific
role
SAH
remains
unclear.
Therefore,
we
aimed
investigate
the
potential
of
phloretin
SAH.
We
established
vitro
and
vivo
models
assess
effects
phloretin.
Subsequently,
utilizing
SAH-related
public
datasets
from
GEO
database,
identified
key
genes
investigated
mechanism
action
Our
findings
reveal
that
significantly
improves
prognostic
outcomes
mitigates
inflammation
mice.
Moreover,
our
results
suggest
neuroinflammation
by
inhibiting
TLR2/MYD88/NF-κB
pathway.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Dec. 1, 2022
About
230
million
people
worldwide
suffer
from
peripheral
arterial
disease
(PAD),
and
the
prevalence
is
increasing
year
by
year.
Multiple
risk
factors,
including
smoking,
dyslipidemia,
diabetes,
hypertension,
can
contribute
to
development
of
PAD.
PAD
typically
characterized
intermittent
claudication
resting
pain,
there
a
severe
limb
ischemia,
leading
major
adverse
events,
such
as
amputation.
Currently,
progress
in
research
field
pathogenesis
vascular
remodeling,
atherosclerosis
neointima
hyperplasia
has
been
made.
For
example,
molecular
mechanisms
endothelial
dysfunction
smooth
muscle
phenotype
switching
have
described.
Interestingly,
series
focused
studies
on
fibroblasts
vessel
wall
demonstrated
their
impact
proliferation
even
function
via
cell-cell
communications.
In
this
review,
we
aim
focus
functional
changes
cells
At
same
time,
summarize
current
clinical
treatment
potential
therapeutic
methods
for
shine
light
future
perspectives.
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(29), P. 31477 - 31487
Published: July 8, 2024
To
improve
the
water
solubility
of
phloretin,
we
synthesized
Phl-4B
cocrystal
using
solvent
evaporation
method.
Various
analytical
techniques
including
powder
X-ray
diffraction
(PXRD),
thermogravimetric
analysis
(TGA),
differential
scanning
calorimetry
(DSC),
Fourier
transform
infrared
(FTIR),
Genes,
Journal Year:
2024,
Volume and Issue:
15(7), P. 942 - 942
Published: July 18, 2024
Diabetes
mellitus
type
2
(T2DM)
is
a
common
chronic
condition
that
presents
as
unsettled
hyperglycemia
(HG)
and
results
from
insulin
resistance
(IR)
β-cell
dysfunction.
T2DM
marked
by
an
increased
risk
of
microvascular
macrovascular
complications,
all
which
can
be
the
cause
increasing
mortality.
Diabetic
nephropathy
(DNE),
neuropathy
(DNU),
retinopathy
(DR)
are
most
complications
diabetic
microangiopathy,
while
cardiomyopathy
(DCM)
peripheral
vascular
diseases
major
macroangiopathy
complications.
Chalcones
(CHs)
in
flavonoid
family
commonly
found
certain
plant
species
intermediate
metabolites
biosynthesis
flavonoids
their
derivatives.
Natural
CHs
with
different
substituents
exert
diverse
therapeutic
activities,
including
antidiabetic
ones.
However,
mechanisms
natural
through
influencing
genes
and/or
signaling
pathways
remain
unknown.
Therefore,
this
review
summarizes
existing
experimental
models
highlight
agents
for
