Paclitaxel and docetaxel resistance in prostate cancer: Molecular mechanisms and possible therapeutic strategies

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114392 - 114392

Published: Feb. 15, 2023

Prostate cancer is among most malignant tumors around the world and this urological tumor can be developed as result of genomic mutations their accumulation during progression towards advanced stage. Due to lack specific symptoms in early stages prostate cancer, patients are diagnosed that cells display low response chemotherapy. Furthermore, enhance aggressiveness cells. Docetaxel paclitaxel suggested well-known compounds for chemotherapy they possess a similar function therapy based on inhibiting depolymerization microtubules, impairing balance microtubules subsequent delay cell cycle progression. The aim current review highlight mechanisms docetaxel resistance cancer. When oncogenic factors such CD133 upregulation PTEN tumor-suppressor shows decrease expression, malignancy enhances induce drug resistance. phytochemicals anti-tumor have been utilized suppressing chemoresistance Naringenin lovastatin used enhancing sensitivity. Moreover, nanostructures polymeric micelles nanobubbles delivery decreasing risk development. These subjects highlighted provide new insight reversing

Language: Английский

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miRNAs as cornerstones in chronic lymphocytic leukemia pathogenesis and therapeutic resistance– An emphasis on the interaction of signaling pathways

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 243, P. 154363 - 154363

Published: Feb. 8, 2023

Language: Английский

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HMGA2 regulation by miRNAs in cancer: Affecting cancer hallmarks and therapy response

Pharmacological Research, Journal Year: 2023, Volume and Issue: 190, P. 106732 - 106732

Published: March 15, 2023

High mobility group A 2 (HMGA2) is a protein that modulates the structure of chromatin in nucleus. Importantly, aberrant expression HMGA2 occurs during carcinogenesis, and this an upstream mediator cancer hallmarks including evasion apoptosis, proliferation, invasion, metastasis, therapy resistance. targets critical signaling pathways such as Wnt/β-catenin mTOR cells. Therefore, suppression function notably decreases progression improves outcome patients. As mainly oncogenic, targeting by non-coding RNAs (ncRNAs) crucial to take into consideration since it affects function. MicroRNAs (miRNAs) belong ncRNAs are master regulators vital cell processes, which affect all aspects hallmarks. Long (lncRNAs) circular (circRNAs), other members ncRNAs, mediators miRNAs. The current review intends discuss importance miRNA/HMGA2 axis modulation various types cancer, mentions lncRNAs circRNAs, regulate mediators. Finally, we effect miRNAs interactions on response cells therapy. Regarding role regulation cells, considering confirmed interaction between one miRNAs, promising could be subject future clinical trial experiments.

Language: Английский

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Correlation between the immune microenvironment and bladder cancer based on a prognostic miRNA risk model

Cancer Insight, Journal Year: 2024, Volume and Issue: 3(2), P. 37 - 48

Published: Jan. 4, 2024

<p class="MsoNormal"><strong><span lang="EN-US" style="mso-bidi-font-size: 10.5pt; font-family: Nunito; mso-bidi-font-family: 'Times New Roman'; mso-bidi-theme-font: minor-bidi; color: #212529; background: white;">Background: </span></strong><span white;">Bladder cancer (BLCA), particularly invasive BLCA, has become a medical burden worldwide as it is associated with recurrence and easy metastasis. There are specific differences in the expression of various miRNAs tumor normal tissues. Hence, can be used biomarkers for diagnosis prognostic evaluation. The current study aimed to predict downstream target genes BLCA-related explore their association immune infiltration. Method: Data on mRNA miRNA levels were downloaded from Cancer Genome Atlas. Correlation analysis Cox regression performed validate risk model. infiltration cells should compared determine distinct between immunological microenvironment two groups. <strong><span style="font-family: minor-bidi;">Results: </span></strong>A predictive framework BLCA was established using miRNAs. showed that low-risk group had better prognosis. Then, predicted, analyzed Gene Ontology Kyoto Encyclopedia Genes Genomes. Moreover, variations functions high- groups assessed. minor-bidi;">Conclusion:</span></strong> features composed (MIR-25, MIR-548AN) may help overall survival BLCA.</span></p>

Language: Английский

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Exosomal miRNAs-mediated macrophage polarization and its potential clinical application

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 117, P. 109905 - 109905

Published: Feb. 27, 2023

Language: Английский

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Lymph node Metastasis in Cancer: Clearing the Clouds to See the Dawn

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 204, P. 104536 - 104536

Published: Oct. 18, 2024

Language: Английский

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Investigating the regulatory role of miRNAs as silent conductors in the management of pathogenesis and therapeutic resistance of pancreatic cancer

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 251, P. 154855 - 154855

Published: Oct. 5, 2023

Language: Английский

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New insight in urological cancer therapy: From epithelial-mesenchymal transition (EMT) to application of nano-biomaterials

Environmental Research, Journal Year: 2023, Volume and Issue: 229, P. 115672 - 115672

Published: March 10, 2023

Language: Английский

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Insights into the genetic and epigenetic mechanisms governing X-chromosome-linked-miRNAs expression in cancer; a step-toward ncRNA precision

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138773 - 138773

Published: Dec. 1, 2024

Language: Английский

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Gene network changes after exposure to nanoliposomes containing antisense miR-21 and miR-373 in bladder cancer Cells: An in vitro model study

Biochemistry and Biophysics Reports, Journal Year: 2025, Volume and Issue: 42, P. 102041 - 102041

Published: May 12, 2025

Language: Английский

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