Cellular Signalling, Journal Year: 2023, Volume and Issue: 109, P. 110786 - 110786
Published: June 27, 2023
Language: Английский
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 255, P. 155132 - 155132
Published: Feb. 1, 2024
Language: Английский
Citations
3
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107302 - 107302
Published: July 13, 2024
Bladder cancer stands as a prevalent global malignancy, exhibiting notable sex-based variations in both incidence and prognosis. Despite substantial strides therapeutic approaches, the formidable challenge of drug resistance persists. The genomic landscape bladder cancer, characterized by intricate clonal heterogeneity, emerges pivotal determinant fostering this resistance. Clonal evolution, encapsulating dynamic transformations within subpopulations tumor cells over time, is implicated emergence drug-resistant traits. Within review, we illuminate contemporary insights into role evolution elucidating its influence driver initiation, disease progression, obstacle therapy
Language: Английский
Citations
3
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 259, P. 155381 - 155381
Published: June 1, 2024
Language: Английский
Citations
2
Molecular Biology Reports, Journal Year: 2022, Volume and Issue: 50(2), P. 1281 - 1291
Published: Nov. 30, 2022
Language: Английский
Citations
9
Translational Andrology and Urology, Journal Year: 2024, Volume and Issue: 13(5), P. 812 - 827
Published: May 1, 2024
Background: Solasonine has been demonstrated to exert an inhibitory effect on bladder cancer (BC), but the potential mechanisms remain unclear. Therefore, aim of this study is explore association between microRNAs (miRNAs)-mediated regulation and anti-tumor activities solasonine in BC. Methods: MiRNA sequencing was performed identify differentially expressed (DE-miRNAs) associated with BC cells. Functional enrichment analyses DE-miRNAs activated inhibited by were then conducted. The prognostic value for those samples subsequently identified as hub DE-miRNAs. After identifying messenger RNAs (mRNAs) that targeted samples, a protein-protein interaction analysis core downstream genes, which used construct solasonine-miRNA-mRNA regulatory network. Results: A total 27 19 solasonine-mediated found be several tumor-related biological functions pathways. integrating results survival expression assessment, following nine identified: hsa-miR-127-3p, hsa-miR-450b-5p, hsa-miR-99a-5p, hsa-miR-197-3p, hsa-miR-423-3p, hsa-miR-4326, hsa-miR-625-3p, hsa-miR-625-5p, hsa-miR-92a-3p. DE-mRNAs predicted, 30 genes miR-450b-5p shown most mRNAs network, suggests it plays crucial role anti-BC effect. Conclusions: including solasonine, miRNAs, related BC, constructed. This network provides extensive insights into molecular underlie anti-cancer efficacy
Language: Английский
Citations
1
Therapeutic Advances in Medical Oncology, Journal Year: 2024, Volume and Issue: 16
Published: Jan. 1, 2024
Background: Repeat transurethral resection of bladder tumour (reTURB) is a conventional treatment for non-muscle-invasive cancer (NMIBC) to enhance prognosis. However, the necessity reTURB in NMIBC remains controversial owing upstaging treatments and new evidence. Objectives: We performed an umbrella review determine need patients with NMIBC. Design: extracted data from meta-analyses that were screened out after systematic search PubMed, Embase, Web Science Cochrane Database Systematic Reviews. Methods: Risk Bias Reviews Grading Recommendations, Assessment, Development Evaluation tools used assess quality each included meta-analysis outcomes. Results: Our study seven meta-analyses. Two studies assessed efficiency who underwent en bloc tumours (ERBT). Patients ERBT reported low residual rates 5.9% 0.3%, respectively. Conversely, (cTURB) had high rates. cTURB significantly improved 1-year recurrence-free survival (RFS) compared those initial alone. In terms progression-free (PFS), PFS subgroup analyses ERBT, did not affect RFS received ERBT. Currently, only limited number randomised clinical trials have evaluated reTURB, various factors influenced its efficacy. Conclusion: There was significant variation outcomes among undergoing reTURB. The efficacy depend on numerous factors, such as surgical approach, equipment medication usage. eligible may constitute group does require Further are required validate these findings. Registration: This registered International Prospective Register (CRD42023439078).
Language: Английский
Citations
1
Clinica Chimica Acta, Journal Year: 2024, Volume and Issue: unknown, P. 120113 - 120113
Published: Dec. 1, 2024
Language: Английский
Citations
1
Aging, Journal Year: 2023, Volume and Issue: 15(21), P. 12192 - 12208
Published: Nov. 3, 2023
N7-methylguanosine (m7G) modification has been notably linked with the development of many tumors. However, no investigations have conducted on whether m7G-related miRNA (m7G-miRNA) is a prognostic index hepatocellular carcinoma (HCC). Therefore, this investigation aimed to establish predictive m7G-miRNA signature for efficient HCC prognosis and elucidate associated immune cell infiltration (ICI) functions in tumor microenvironment. RNA sequencing clinical data 375 50 healthy tissue samples were acquired from The Cancer Genome Atlas database. regulators methyltransferase-like 1 WD repeat domain 4 TargetScan Univariate Cox regression analysis was 63 differentially expressed m7G-miRNAs identified. A that consisted seven miRNAs According their risk scores, individuals divided into high-risk (HR) low-risk (LR) cohorts. Kaplan-Meier test revealed survival HR patients poorer than LR cohort (p < 0.001). area under receiver operating characteristic curves 1-, 3-, 5-year overall 0.706, 0.695, 0.715, respectively. nomogram sex, score, age, stage indicated patients' survival. Furthermore, it had different degrees ICI function. pathway enrichment association several immunity-linked pathways model. In conclusion, established great value could be used as new immunotherapy target HCC.
Language: Английский
Citations
3
Mathematics, Journal Year: 2023, Volume and Issue: 11(19), P. 4118 - 4118
Published: Sept. 28, 2023
Urinary tract cancers are considered life-threatening conditions worldwide, and Bladder Cancer is one of the most malignant urinary tumors, with an estimated number more than 1.3 million cases worldwide each year. a heterogeneous disease; main symptom painless hematuria. However, patients may initially be misdiagnosed as Cystitis or infection, cystoscopy alone sometimes urolithiasis Cystitis, thereby delaying medical attention. Early diagnosis key to successful treatment. This study uses six deep learning methods through different oversampling techniques feature selection, then dimensionality reduction techniques, establish set that can effectively distinguish between patient’s model. The research results show based on laboratory clinical dataset, model proposed in this has accuracy rate 89.03% distinguishing surpassing previous studies. developed provided clinicians reference differentiate Cystitis.
Language: Английский
Citations
2
Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 4, 2024
Language: Английский
Citations
0