Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 76
Published: Jan. 1, 2024
Language: Английский
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 16, 2024
Introduction This double-blind, placebo-controlled, randomized (1:1) clinical trial was conducted at the West China Hospital, Sichuan University, from March to September 2017. Methods Eligible participants included adults aged 18 years and older, living in community, diagnosed with type 2 Diabetes Mellitus according ADA guidelines, capable of self-managing their diabetes, able visit study site for follow-up. The intervention group received 25 ml a probiotic beverage containing over 10^8 CFU/mL Lactobacillus, administered four times daily. An equal volume inactivated Lactobacillus control same Lactobacillus. aimed evaluate effectiveness probiotics on glycemic other diabetes-related outcomes patients diabetes patients. primary were changes HbA1c FBG levels post-intervention. Investigators, participants, personnel blinded treatment allocation until conclusion study. randomized, placebo-controlled registered Chinese Clinical Trial Registry (ChiCTR-POR-17010850). Results Of 490 screened, 213 either (n = 103) or placebo 110). After 16 weeks follow-up, showed reductions [-0.44 (-0.66 -0.22)] [-0.97 (-1.49 0.46)] post-intervention, similar [-0.33 (-0.52 -0.15)] [-0.90 (-1.32 -0.47)], but these not statistically significant PP ITT analyses (P>0.05). Adverse events similarly distributed among groups, indicating comparable safety profiles. Discussion Overall, 16-week supplementation no beneficial effects control, lipid profiles, weight. Registration https://www.chictr.org.cn/showproj.html?proj=18421 , identifier ChiCTR-POR-17010850.
Language: Английский
Citations
1
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: Oct. 18, 2024
Diabetes mellitus can be subdivided into several categories based on origin and clinical characteristics. The most common forms of diabetes are type 1 (T1D), 2 (T2D) gestational (GDM). T1D T2D chronic diseases affecting around 537 million adults worldwide it is projected that these numbers will increase by 12% over the next two decades, while GDM affects up to 30% women during pregnancy, depending diagnosis methods. These have varied origins: an autoimmune disease, commonly associated with, but not limited to, certain lifestyle patterns result a combination genetic predisposition pregnancy factors. Despite some pathogenic differences among diabetes, there markers with their development. For instance, gut barrier impairment inflammation unbalanced microbiota metabolites may factors in development progression. Here, we summarize microbial signatures been linked how they connected diet and, ultimately, impact metabolite profiles resulting from host-gut microbiota-diet interactions. Additionally, recent advances relating promising preventive therapeutic interventions focusing targeted modulation alleviate T1D, GDM.
Language: Английский
Citations
1
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10590 - 10590
Published: June 24, 2023
A commercial strain of Hafnia alvei (H. alvei) 4597 bacteria was shown to reduce food intake and promote weight loss, effects possibly induced by the bacterial protein ClpB, an antigen-mimetic anorexigenic α-melanocyte-stimulating hormone. decrease in basal plasma glucose levels also observed overweight fasted humans mice receiving H. alvei. However, it is not known whether influences sweet taste preference its extract or ClpB are sufficient increase tolerance; these objectives tested present study. C57BL/6J male were kept under standard diet gavaged daily for 17 days with a suspension (4.5 × 107 CFU/animal) total (5 μg/animal) saline as control. Sweet analyzed via brief-access licking test sucrose solution. Glucose tolerance tests (GTT) performed after intraperitoneal (IP) intragastric (IG) administration at 9th 15th gavage, respectively. The expression regulatory peptides' mRNA assayed hypothalamus. In another experiment non-treated mice, acute IP recombinant on studied both IP- IG-GTT. Mice treated showed improved IP-GTT but Both groups reduction pancreatic tissue without significant changes insulin. No preference, insulin Acute increased during IG-GTT, reduced levels. We conclude that introduced orally administered improve probably acting postabsorptive level. Moreover, probiotic does seem influence preference. These results justify future testing animal models diabetes.
Language: Английский
Citations
3
Deleted Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Feb. 1, 2024
A systematic review and meta-analysis study was conducted to assess the effectiveness of probiotic/prebiotic/synbiotic supplementation on effects cardiovascular risk factors in patients with type 2 diabetes mellitus (T2DM) based data from randomized controlled trials (RCTs). We searched electronic databases including PubMed, Cochrane Library, Embase, Web Science identify clinical published up 31 March 2023. Data pooled using a random-effects model if significant heterogeneity (I² > 50%), otherwise use fixed-effects model. Fifty-six that included 3 317 were enrolled for analysis. Meta-analysis reported significantly reduced systolic blood pressure (SBP) (weighted mean difference (WMD): −3.57 mmHg, 95% confidence interval (CI): −5.36, −1.78; P = 0.000), diastolic (DBP) (WMD: −2.05 CI: −3.07, −1.04; triglycerides (TG) −16.10 mg/dL, −20.16, −12.05; total cholesterol (TC) −14.00 −20.46, −7.55; low-density lipoprotein (LDL-C) −7.03 −9.25, −4.81; fasting plasma glucose (FPG) −16.57 −20.39, −12.74; hemoglobin A1c (HbA1c) −0.44%, −0.68, −0.20; insulin (standardized (SMD): −0.37, −0.53, −0.21; homeostatic assessment resistance (HOMA-IR) −1.05, −1.56, −0.54; C-reactive protein (CRP) (SMD: −0.35, −0.57, −0.13; 0.002), tumor necrosis factor-α (TNF-α) −1.07, −1.57, −0.56; interleukin-6 (IL-6) −0.37 , −0.61, 0.003) levels, they also increased high-density (HDL-C) 3.70 1.80, 5.60; 0.000) levels T2DM patients, as compared placebo groups. This supports an adjunctive therapy improve pressure, glycemic control parameters, lipid profile inflammatory markers T2DM, which are well-known factors.
Language: Английский
Citations
0
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 43 - 76
Published: Jan. 1, 2024
Language: Английский
Citations
0