Nicotinic Acetylcholine Receptors in Glial Cells as Molecular Target for Parkinson’s Disease

Cells, Journal Year: 2024, Volume and Issue: 13(6), P. 474 - 474

Published: March 7, 2024

Parkinson’s disease (PD) is a progressive neurodegenerative characterized by resting tremor, bradykinesia, rigidity, and postural instability that also includes non-motor symptoms such as mood dysregulation. Dopamine (DA) the primary neurotransmitter involved in this disease, but cholinergic imbalance has been implicated. Current intervention PD focused on replenishing central DA, which provides remarkable temporary symptomatic relief does not address neuronal loss progression of disease. It well established nicotinic receptors (nAChRs) can regulate DA release nicotine itself may have neuroprotective effects. Recent studies identified nAChRs nonneuronal cell types, including glial cells, where they inflammatory responses. Given crucial role neuroinflammation dopaminergic degeneration involvement microglia astrocytes response, provide novel therapeutic target prevention and/or treatment PD. In review, following brief discussion PD, we focus cells and, specifically, their pathology treatment.

Language: Английский

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Structural properties of glucan from Russula griseocarnosa and its immunomodulatory activities mediated via T cell differentiation

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 339, P. 122214 - 122214

Published: April 27, 2024

Language: Английский

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Neurobiological mechanisms of nicotine's effects on feeding and body weight

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: 169, P. 106021 - 106021

Published: Jan. 16, 2025

Language: Английский

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Choline alleviates cognitive impairment in sleep-deprived young mice via reducing neuroinflammation and altering phospholipidomic profile

Redox Biology, Journal Year: 2025, Volume and Issue: 81, P. 103578 - 103578

Published: March 1, 2025

Cognitive impairment resulting from insufficient sleep poses a significant public health concern, particularly in children. The effects and mechanisms of choline on cognitive caused by deprivation are unknown. Chronic is induced young mice this study, followed feeding diet containing 11.36 g/kg bitartrate. Choline supplementation significantly improves spatial learning ability. Functional MRI results reveal the hippocampus as key region affected deprivation, where notably preserves hippocampal structural integrity enhanced connectivity. Additionally, ameliorates pathological injury, reduces blood-brain barrier permeability serum brain injury biomarkers. also inflammation oxidative stress biomarkers, mitigates microglial activation hippocampus, which synaptic plasticity. A finding changes phospholipidomic profile along with function, total 313 phospholipid molecules identified. increases levels sub-classes (particularly PC), strongly correlated reduced neuroinflammation well improved outcomes. Furthermore, there similar findings some such PC 36:1, O-33:0, p-38:3, PE 36:3, p-42:4 PS 44:12. These highlight that alleviates via reducing altering profile. This study suggests could develop into functional food or medicine ingredient to prevent treat disturbances, children adolescents.

Language: Английский

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Cholinergic signaling via the α7 nicotinic acetylcholine receptor regulates the migration of monocyte-derived macrophages during acute inflammation

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Jan. 4, 2024

The involvement of the autonomic nervous system in regulation inflammation is an emerging concept with significant potential for clinical applications. Recent studies demonstrate that stimulating vagus nerve activates cholinergic anti-inflammatory pathway inhibits pro-inflammatory cytokines and controls inflammation. α7 nicotinic acetylcholine receptor (α7nAChR) on macrophages plays a key role mediating effects through downstream intracellular mechanism involving inhibition NF-κB signaling, which results suppression cytokine production. However, α7nAChR other aspects immune response, including recruitment monocytes/macrophages to site remained poorly understood. We observed increased mortality α7nAChR-deficient mice (compared wild-type controls) endotoxemia, was paralleled reduction number monocyte-derived lungs. Corroborating these results, fluorescently labeled monocytes adoptively transferred WT showed significantly diminished inflamed tissue. deficiency did not affect monocyte 2D transmigration across endothelial monolayer, but it decreased migration 3D fibrin matrix. In vitro analysis major adhesive receptors (L-selectin, β1 β2 integrins) chemokine (CCR2 CCR5) revealed reduced expression integrin αM αX macrophages. Decreased αMβ2 confirmed labeled, lungs endotoxemic mice, indicating α7nAChR-mediated migration. novel macrophage tissue, indicates important new aspect responses

Language: Английский

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Magnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats

Journal of Nanobiotechnology, Journal Year: 2023, Volume and Issue: 21(1)

Published: Nov. 14, 2023

Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized over-activated sympathetic tone and reduced vagal nerve activity. In our preceding study, we pioneered development of magnetic vagus stimulation (mVNS) system. This system showcased precise stimulation, demonstrating remarkable effectiveness safety treating myocardial infarction. However, it remains uncertain whether mVNS can mitigate I/R its specific underlying mechanisms. this utilized a rat model to delve into therapeutic potential against type injury.Our findings revealed that treatment led reduction infarct size, decrease ventricular fibrillation (VF) incidence curbing inflammatory cytokine release. Mechanistically, demonstrated beneficial effects on inhibiting NLRP3-mediated pyroptosis through M2AChR/OGDHL/ROS axis.Collectively, these outcomes highlight promising as strategy for injury.

Language: Английский

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Investigating the role of eight SNPs in CHRNA3 for COPD susceptibility in the Chinese elderly population

Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)

Published: March 12, 2025

Background Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality among the elderly in China. Genetic predisposition recognized risk factor for COPD, with CHRNA3 emerging as promising candidate gene due to its involvement smoking behavior lung function. This study aimed investigate association between eight SNPs COPD susceptibility Chinese population.

Language: Английский

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Electroacupuncture Attenuates Intestinal Barrier Disruption via the α7nAChR-Mediated HO-1/p38 MAPK/NF-κB Pathway in a Mouse Model of Metabolic Dysfunction-Associated Fatty Liver Disease: A Randomized, Single-Blind, Controlled Trial

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 802 - 802

Published: March 27, 2025

Background: Gut barrier integrity plays a crucial role in the pathogenesis of metabolic dysfunction-associated fatty liver disease (MAFLD). Electroacupuncture (EA) at ST-36 can ameliorate inflammatory responses via stimulating α7 nicotinic acetylcholine receptor (α7nAChR), but whether EA is effective preserving intestinal MAFLD has not been exactly illustrated. This investigation explored potential protection mechanisms targeting dismantled gut MAFLD. Methods: C57BL/6 mice were randomly allocated into several subgroups: control (CON), high-fat diet (HFD), HFD with EA, and α7nAChR inhibitor α-BGT, HO-1 knockout (KO). Body weight, visceral fat index, histopathological examination intestine determined. Serum biological indexes evaluated through corresponding kits. Furthermore, expressions HO-1, α7nAChR, barrier-associated proteins, molecular tissues assessed Western blot, RT-qPCR, immunohistology, or immunofluorescence examination. Results: treatment decreased body index gain mitigated function injury abnormal lipid indexes, exhibiting less severity hepatic steatosis, fibrosis, inflammation Lower permeability, epithelial disruption, upregulation tight junction proteins after suggested protective effects attenuating dysfunction. These abolished by α-BGT deletion. Mechanistically, markedly enriched expression phosphorylated p38 MAPK/NF-κB activation, which was lost KO treatment. Conclusions: The may be attributed to preserved barrier, thereby alleviating systemic preventing subsequent hits, where α7nAChR-mediated HO-1/p38 pathway maintain homeostasis.

Language: Английский

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Natural Alkaloids Modulating Macrophage Polarization: Innovative Therapeutic Strategies for Inflammatory, Cardiovascular, and Cancerous Diseases

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156709 - 156709

Published: April 1, 2025

Language: Английский

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Exploring the Potential Role of the Cholinergic Anti-Inflammatory Pathway from the Perspective of Sepsis Pathophysiology

Journal of Intensive Care Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Sepsis is one of the most prevalent conditions in critical care medicine and characterized by a high incidence, mortality, poor prognosis, with no specific treatment currently available. The pathogenesis sepsis complex dysregulated inflammatory response at its core. If initial not promptly controlled, patients often develop multiple organ dysfunction syndrome or die, whereas survivors may experience post-sepsis syndrome. Regulation central autonomic nervous systems essential for maintaining homeostasis. Among these, cholinergic anti-inflammatory pathway (CAP) has been extensively studied owing to significant role modulating responses. Recent advancements CAP-related interventions include minimally invasive vagus nerve stimulation, novel α7nAchR-targeting drugs, serum choline acetyltransferase cholinesterase, acupuncture, focused ultrasound stimulation therapy. This review primarily discusses advantages, limitations, therapeutic prospects these approaches. Additionally, heart rate variability, which reflects changes system function, can serve as an indicator assessing functional status nerve. In summary, modulation responses through nerve-mediated CAP represents potential strategy achieving precision sepsis. Future research should focus on conducting high-quality clinical studies CAP-based therapies context sepsis-induced dysregulation. Incorporating indicators evaluate function further elucidate impact dysregulation body.

Language: Английский

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