Advances in hepatocellular carcinoma drug resistance models DOI Creative Commons
Yien Xiang, Junhua Wu,

Hanjiao Qin

et al.

Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11

Published: July 31, 2024

Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Surgery has been major treatment method for HCC owing to HCC’s poor sensitivity radiotherapy and chemotherapy. However, its effectiveness limited by postoperative tumour recurrence metastasis. Systemic therapy applied eliminate residual cells improve survival of patients with advanced HCC. Recently, emergence various novel targeted immunotherapeutic drugs significantly improved prognosis immunological therapies may not always produce complete long-lasting anti-tumour responses because heterogeneity drug resistance. Traditional patient-derived cell lines or animal models are used investigate resistance mechanisms identify that could reverse This study comprehensively reviewed established methods applications in-vivo in-vitro further understand in provide a model basis possible individualised therapy.

Language: Английский

Therapeutic advances of targeting receptor tyrosine kinases in cancer DOI Creative Commons
Ciprian Tomuleasa, Adrian Bogdan Țigu, Raluca Munteanu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 14, 2024

Abstract Receptor tyrosine kinases (RTKs), a category of transmembrane receptors, have gained significant clinical attention in oncology due to their central role cancer pathogenesis. Genetic alterations, including mutations, amplifications, and overexpression certain RTKs, are critical creating environments conducive tumor development. Following discovery, extensive research has revealed how RTK dysregulation contributes oncogenesis, with many subtypes showing dependency on aberrant signaling for proliferation, survival progression. These findings paved the way targeted therapies that aim inhibit crucial biological pathways cancer. As result, RTKs emerged as primary targets anticancer therapeutic Over past two decades, this led synthesis validation numerous small molecule kinase inhibitors (TKIs), now effectively utilized treating various types. In manuscript we provide comprehensive understanding context We explored alterations specific receptors across different malignancies, special dedicated examination current inhibitors, highlighting potential therapies. By integrating latest evidence, seek elucidate pivotal biology efficacy inhibition promising treatment outcomes.

Language: Английский

Citations

28
Hepatocellular carcinoma: signaling pathways and therapeutic advances DOI Creative Commons

Jiaojiao Zheng,

Siying Wang, Lei Xia

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 6, 2025

Abstract Liver cancer represents a major global health concern, with projections indicating that the number of new cases could surpass 1 million annually by 2025. Hepatocellular carcinoma (HCC) constitutes around 90% liver and is primarily linked to factors incluidng aflatoxin, hepatitis B (HBV) C (HCV), metabolic disorders. There are no obvious symptoms in early stage HCC, which often leads delays diagnosis. Therefore, HCC patients usually present tumors advanced incurable stages. Several signaling pathways dis-regulated cause uncontrolled cell propagation, metastasis, recurrence HCC. Beyond frequently altered therapeutically targeted receptor tyrosine kinase (RTK) involved differentiation, telomere regulation, epigenetic modification stress response also provide therapeutic potential. Investigating key their inhibitors pivotal for achieving advancements management At present, primary approaches (TKI), immune checkpoint (ICI), combination regimens. New trials investigating therapies involving ICIs TKIs or anti-VEGF (endothelial growth factor) therapies, as well combinations two immunotherapy The outcomes these expected revolutionize across all Here, we here comprehensive review cellular pathways, potential, evidence derived from late-stage clinical discuss concepts underlying earlier trials, biomarker identification, development more effective therapeutics

Language: Английский

Citations

7
Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target DOI Creative Commons
Junaid Abid,

Basil A. Mahmood Al-Rawi,

Ahmad Mahmood

et al.

Hereditas, Journal Year: 2025, Volume and Issue: 162(1)

Published: March 24, 2025

Abstract Diffuse large B-cell lymphoma (DLBC) is the most common subtype of non-Hodgkin lymphoma, characterized by its aggressive nature and poor prognosis in advanced stages. Despite advances treatment, molecular mechanisms driving DLBC progression remain incompletely understood, necessitating identification novel biomarkers for diagnosis prognosis. In this study, we analyzed two publicly available datasets (GSE32018 GSE56315) from Gene Expression Omnibus database (GEO) to identify overlapping differentially expressed genes (DEGs). Later on, a comprehensive silico vitro methodology was adopted decipher role DEGs DLBC. analysis GSE32018 GSE56315 identified five gene: SP3, CSNK1A1, STYX, SIRT5, MGEA5. validation using GEPIA2 confirmed upregulation downregulation MGEA5 tissues compared normal controls. Furthermore, mutational revealed that CSNK1A1 only gene among these exhibit mutations, with 2.7% mutation frequency patients. Methylation highlighted negative correlation between methylation levels mRNA expression, while survival high STYX expression as significantly associated poorer overall Functional assays demonstrated knockdown U2932 cells led reduced cell proliferation, colony formation, enhanced wound healing, indicating STYX’s pivotal migration. Additionally, enrichment involvement key biological processes, including intracellular trafficking myeloid progenitor differentiation. These findings emphasize potential therapeutic targets DLBC, particularly highlighting promising prognostic marker target intervention.

Language: Английский

Citations

1
IL-2-loaded liposomes modified with sorafenib derivative exert a synergistic anti-melanoma effect via improving tumor immune microenvironment and enhancing antiangiogenic activity DOI Creative Commons
Xuan Huang,

Kudelaidi Kuerban,

J P Fan

et al.

Asian Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 101020 - 101020

Published: Jan. 1, 2025

Language: Английский

Citations

0
The value of ITGA and ITGB superfamily genes as biomarkers for the early diagnosis and prognosis of gliomas: A retrospective observational study based on the GEPIA and CGGA databases DOI Creative Commons
Ben Yang, Yuqi Han, Mengqi Shi

et al.

NeuroMarkers., Journal Year: 2025, Volume and Issue: unknown, P. 100039 - 100039

Published: Feb. 1, 2025

Language: Английский

Citations

0
Decoding Alzheimer's Disease With Depression: Molecular Insights and Therapeutic Target DOI Creative Commons
Zekun Li,

Hongmin Guo,

Yihao Ge

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(5)

Published: March 1, 2025

ABSTRACT The purpose of this study was to recognise predictive biomarkers and explore the promising therapeutic targets AD with depression. We confirmed a positive correlation between depression through MR Analysis. Through WGCNA analysis, we identified 1569 genes containing two modules, which were most related AD. In addition, 1629 depressive DEGs also identified. these genes, 84 shared by both depression, screened Degree algorithm, MCC four machine learning algorithms. Two (ITGB5 SPCS1) as AUC > 0.7. Furthermore, nomogram indicated that ITGB5 SPCS1 are good in diagnosing Four drugs targeted at determined DGIdb website. conclusion, for thus providing

Language: Английский

Citations

0
Integrins in Cancer Drug Resistance: Molecular Mechanisms and Clinical Implications DOI Open Access
Yoshinobu Kariya, Michiru Nishita

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3143 - 3143

Published: March 28, 2025

It is estimated that between 80 and 90% of mortality in cancer patients directly or indirectly related to drug resistance. Consequently, overcoming resistance represents a significant challenge the treatment cancer. Integrins are transmembrane adhesion molecules facilitate linkage extracellular matrix (ECM) cytoskeleton, thereby enabling activation various cellular signaling pathways. highly expressed cancers contribute progression through invasion metastasis. In addition, recent studies have revealed integrins play pivotal role development This review will first provide an overview integrin function classification. then discusses advances understanding how cancer, with focus on ECM, transporters, epithelial-to-mesenchymal transition (EMT), stemness, PD-L1, glycosylation. Finally, potential applications as targets for therapeutic agents against drug-resistant also summarized.

Language: Английский

Citations

0
Investigating the Anticancer Effect of Purified rCec-B Peptide in a DEN Murine Model: Insights into Tumorigenesis Prevention, Bioavailability, and Molecular Mechanisms DOI
Hend Okasha, Sami Mohamed Nasr, Ehab Hafiz

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110468 - 110468

Published: May 1, 2025

Language: Английский

Citations

0
Multi-Omics Approaches Uncovered Critical mRNA–miRNA–lncRNA Networks Regulating Multiple Birth Traits in Goat Ovaries DOI Open Access
Weibing Lv,

Ren Bo An,

Xinmiao Li

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12466 - 12466

Published: Nov. 20, 2024

The goat breeding industry on the Tibetan Plateau faces strong selection pressure to enhance fertility. Consequently, there is an urgent need develop lines with higher fertility and adaptability. ovary, as a key organ determining reproductive performance, regulated by complex transcriptional network involving numerous protein-coding non-coding genes. However, molecular mechanisms of mRNA-miRNA-lncRNA regulatory in ovaries remain largely unknown. This study focused histology differential mRNA/miRNA/lncRNA between Chuanzhong black (CBG, high productivity, multiple births) (TG, adaptability, single birth) ovaries. Histomorphological analysis showed that medulla proportion CBG was significantly reduced compared TG. RNA-Seq small identified 1218 differentially expressed (DE) mRNAs, 100 DE miRNAs, 326 lncRNAs, which were mainly enriched ovarian steroidogenesis, oocyte meiosis, biosynthesis amino acids protein digestion, absorption signaling pathways. Additionally, five interaction networks regulating performance identified, including

Language: Английский

Citations

3
Mechanisms of sorafenib resistance in hepatocellular carcinoma DOI
Yuanjing Liang

Clinics and Research in Hepatology and Gastroenterology, Journal Year: 2024, Volume and Issue: 48(8), P. 102434 - 102434

Published: July 29, 2024

Language: Английский

Citations

2