An exploratory investigation of lipid-lowering potential of spirulina ( Arthrospira platensis ) targeting apoprotein-E in chronic hyperlipidemic wistar albino rats DOI Creative Commons

Anum Nazir,

M. Nisa,

Mohamed H. Mahmoud

et al.

Cogent Food & Agriculture, Journal Year: 2024, Volume and Issue: 10(1)

Published: Nov. 3, 2024

Spirulina (Arthrospira platensis) is the most famous species of microalgae and a possible source important chemicals therapeutic metabolites with variety pharmacological effects. This study investigated nutritional profile spirulina powder its potential to decrease hyperlipidemia in male Wistar albino rats. The rats were divided into five groups: G1 (spirulina 300 mg/kg), G2 600 G3 900 PC (positive control; no treatment), NC [negative control + chow rodent diet (CMD)] throughout experimental period. Blood samples from analyzed for albumin apoprotein-E, low-density lipoprotein (LDL), high-density (HDL), triglycerides, cholesterol levels. Rat liver tissues examined histopathologically observe morphological changes before after course treatment. Overall findings demonstrated that comparison all other groups except NC, high dose (900 mg/kg) significantly decreased levels (68.8 ± 1.4 mg/dl), triglyceride (86.7 2.2 LDL (20 0.82 mg/dl). However, it also increased HDL (46.8 2.46 mg/dl) apoprotein-E (6.13 0.1). Alanine transaminase (ALT) aspartate aminotransferase (AST) (p ≤ 0.05) reduced treatment compared PC, NC. In conclusion, an excellent mitigate hyperlipidemia, promising prevention chronic diseases.

Language: Английский

Algae Application for Treating Wastewater Contaminated with Heavy Metal Ions DOI
Ali Aghababai Beni,

Mina Haghmohammadi,

Soheila Delnabi Asl

et al.

Environmental science and engineering, Journal Year: 2024, Volume and Issue: unknown, P. 297 - 322

Published: Jan. 1, 2024

Language: Английский

Citations

7
Spirulina maxima supplementation: benefits and limitations – results of latest studies DOI Creative Commons

Natalia Dąbrowska,

Krzysztof Marcinkowski, Agata Mazur

et al.

Journal of Pre-Clinical and Clinical Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

1. Pyne PK, Bhattacharjee P, Srivastav PP. Microalgae (Spirulina Platensis) and Its Bioactive Molecules: Review. Indian J Nutri. 2017;4(2):160. Google Scholar

Language: Английский

Citations

5
The Effects of Spirulina Supplementation on Cardiometabolic Risk Factors: A Narrative Review DOI Creative Commons
Sara Sokary, Hiba Bawadi, Zain Zaki Zakaria

et al.

Journal of Dietary Supplements, Journal Year: 2024, Volume and Issue: 21(4), P. 527 - 542

Published: Jan. 22, 2024

Spirulina (Arthrospira platensis) is a cyanobacterium associated with multiple health benefits. Cardiometabolic diseases such as cardiovascular disease, nonalcoholic fatty liver and diabetes are prevalent yet usually preventable non-communicable diseases. Modifiable risk factors for cardiometabolic include excessive body weight, inflammation, atherogenic lipid profile, imbalanced glucose metabolism. This review explores the effects of spirulina on factors. was effective in reducing mass index, waist circumference, potential dose-dependent effect. It also decreased interleukin 6, an important biomarker by inhibiting NADPH oxidase enzyme, lowering insulin resistance. supplementation reduced triglycerides, low-density lipoprotein cholesterol, increased high-density cholesterol. Additionally, fasting blood sugar post-prandial sensitivity, but no effect observed glycated hemoglobin A1c. The diverse nutrients, phycocyanin, gamma-linolenic acid, vitamin B12, present contribute to its doses used heterogeneous most studies, ranging from 1 8 grams daily, studies administered 3 months observe collective evidence suggests that supplements may help improve diseases, thus, preventing development. However, due heterogeneity results, more randomized clinical trials needed draw robust conclusions about spirulina's therapeutic ameliorating fully elucidate mechanisms which it exerts effects.

Language: Английский

Citations

4
The Effect of Spirulina Supplementation on Blood Pressure in Adults: A GRADE‐Assessed Systematic Review and Meta‐Analysis of Randomized Clinical Trials DOI Open Access
Hamidreza Shiri,

Javad Yasbolaghi Sharahi,

Maryam Alizadeh Sani

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Previous studies have yielded controversial results regarding the effect of spirulina on blood pressure (BP), which need updating. So, this updated systematic review and meta-analysis randomized controlled trials (RCTs) carry out a more accurate estimation BP in adults. This searches (in PubMed/Medline, Scopus, ISI Web Science) until April 1, 2024, to identify related RCTs based PICOS guidelines (population (individuals > 18 years old), intervention (spirulina), comparison (control or placebo group), outcomes (systolic (SBP) diastolic (DBP)), study design (RCTs)), PRISMA-checklist (Supporting Information, data S2). We evaluated impact DBP SBP. Conventional procedures were employed for analyzing publication bias, heterogeneity, sensitivity. The GRADE criteria Cochrane assessment method evaluate risk bias (ROB) certainty evidence across studies, respectively. result shows consumption decreases SBP (WMD: -4.41 mmHg, 95% CI: -6.74 -2.07, I

Language: Английский

Citations

2
The Effects of Okra Consumption on Glycemic Parameters and Lipid Profile in Adults: A Systematic Review and Meta‐Analysis DOI Creative Commons
Xiaolei Zhang,

Jinxin Miao,

Yagang Song

et al.

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(12), P. 10049 - 10058

Published: Nov. 20, 2024

ABSTRACT The clinical research findings on the effects of okra consumption blood glucose and lipids are inconsistent. In this study, we aimed to explore impact glycemic parameters lipid profile in adults, including homeostatic model assessment for insulin resistance (HOMA‐IR), glycosylated hemoglobin A1c (HbA1c), fasting (FBG), triglyceride (TG), total cholesterol (TC), low‐density lipoprotein (LDL‐C), high‐density (HDL‐C). To find relevant randomized controlled trials (RCTs), systemically searched EMBASE, Web Science, PubMed, Cochrane Library, Scopus until April 2024. According inclusion exclusion criteria, eight studies involving 521 participants were ultimately included present study. Compared placebo, remarkably decreased FBG (WMD: −32.56 mg/dL; 95% CI: −48.83, −16.28; p < 0.001; I 2 = 84.7%), HbA1c −0.48%; −0.81, −0.16; 0.004; 5.5%), TG −13.16 −23.54, −2.77; 0.013; 0.0%), TC −9.70 −14.95, −4.46; 38.3%) adults. However, showed no notable HOMA‐IR, HDL‐C, LDL‐C. Okra has an improving effect adult FBG, HbA1c, TG, levels. More large‐scale RCT necessary validate beneficial adults due limited number RCTs. Trial Registration: PROSPERO: CRD42024540121

Language: Английский

Citations

2
The Effect of Ginseng Supplementation on Lipid Profile: GRADE-assessed Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials DOI
Seyyed Mostafa Arabi,

Mostafa Shahraki-Jazinaki,

Maryam Nayyer Abadi

et al.

Current Pharmaceutical Design, Journal Year: 2024, Volume and Issue: 30(26), P. 2047 - 2058

Published: June 15, 2024

Background: This systematic review and meta-analysis aimed to evaluate the overall impact of Panax ginseng on lipid profile by synthesizing existing evidence. Cardiovascular Disease (CVD) is leading cause morbidity mortality among elderly population, serum lipids play a crucial role in its development. Maintaining optimal levels triglycerides, high-density lipoprotein cholesterol, low-density total cholesterol essential reducing risk CVD. Ginsenosides, active constituents ginseng, have shown positive effects metabolism. provide comprehensive understanding potential benefits managing dyslipidemia, which could significant implications for prevention treatment Methods: A analysis 29 Randomized Controlled Trials (RCTs) was conducted assess supplementation profile, including Triglyceride (TG), Total Cholesterol (TC), High-density Lipoprotein (HDL-C), Low-density (LDL-C) levels. search done online databases, such as MEDLINE, Scopus, Clarivate Analytics Web Science, using relevant keywords MeSH terms identify studies until January 2024. Results: The Weighted Mean Differences (WMD) 95% Confidence Intervals (CI) TG, TC, LDL-C, HDL-C did not show changes with supplementation. Conclusion: Taking into account results, statistically influence parameters individuals different health conditions. Further, well-designed RCTs focusing specific diseases are needed clarify beneficial derivatives profile.

Language: Английский

Citations

1
Arthrospira platensis F&M-C265 reduces cardiometabolic risk factors in rats fed a high fat diet DOI Creative Commons
Mario D’Ambrosio, Elisabetta Bigagli, Lorenzo Cinci

et al.

Journal of Functional Foods, Journal Year: 2024, Volume and Issue: 116, P. 106150 - 106150

Published: March 28, 2024

Clinical studies indicate that Arthrospira platensis (A. platensis) mitigates cardiometabolic risk factors, but the underlying mechanisms are very elusive. To fill this gap, Sprague-Dowley rats were fed either AIN-76 normal diet (5 % corn oil) or high-fat (HF; 30 lard + 3 HF 5 A. F&M-C256 for months. decreased blood triglycerides and total cholesterol, systolic diastolic pressure enhanced expression of thermogenesis-related genes Prdm16, Dio2, PPARγ, Ucp1 Lpl in visceral adipose tissue, compared to HF-diet. reduced ANGPTL3 plasma levels hepatic steatosis, prevented periaortic tissue hypertrophy increased aortic eNOS expression. These data provide some mechanistic evidence about beneficial effects observed human studies. Further controlled trials needed verify clinical usefulness supplementation against metabolic disorders, select dosing regimens subgroup patients with likelihood benefit.

Language: Английский

Citations

1
Multiple health outcomes associated with algae and its extracts supplementation: An umbrella review of systematic reviews and meta‐analyses DOI Open Access
Caixia Wang, Ruixue Min,

Qilun Zhou

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: 38(11), P. 5162 - 5183

Published: Aug. 20, 2024

Abstract Algae and its extracts, widely consumed as functional foods, offer numerous health benefits; however, a comprehensive systematic summary of clinical evidence is currently lacking. The study was to assess the available provide an accurate estimate overall effects algae extracts supplementation on various outcomes. searches in PubMed, Scopus, Embase, Web Science, Cochrane Library until December 22, 2023 were implemented. random‐effects model employed pool effect sizes (ESs) corresponding 95% confidence intervals (CIs) using Stata software. Moreover, detecting methodological quality level eligible studies by A Measurement Tool Assess Systematic Review 2 (AMSTAR2) Grading Recommendations Assessment Development Evaluation. Ultimately, 25 articles covering 133 outcomes included this umbrella review. pooled results demonstrated that could significantly decrease body weight (ES = −1.65; CI: −1.97, −1.34; p < 0.001), mass index (BMI) −0.42; −0.78, −0.07; 0.020), waist circumference (WC) −1.40; −1.40, −1.39; triglyceride (TG) −1.38; −2.15, −0.62; total cholesterol (TC) (ES: −2.09, −0.72; very low‐density lipoprotein (VLDL‐C) −7.85; −8.55, −7.15; fasting blood glucose −2.68; −4.57, −0.79; 0.005), glycated hemoglobin (HbA1c) −0.15; −0.24, systolic pressure −3.21; −5.25, −1.17; 0.002), diastolic −3.84; −7.02, −0.65; 0.018), alanine transaminase −0.70, −0.14; 0.003), alkaline phosphatase −0.54; −0.99, −0.10; 0.017). Due limited number studies, no benefit displayed markers inflammation oxidative stress. Considering suboptimal insufficient pertaining certain outcomes, further well‐designed research imperative substantiate observed findings.

Language: Английский

Citations

1
Effect of oral dosage of Spirulina platensis and silver nanoparticles on glucose, lipid profile, and liver enzymes in male rats induced di-abetics by alloxan DOI Creative Commons
Saad D. Oleiwi

Journal of Kerbala for Agricultural Sciences, Journal Year: 2024, Volume and Issue: 11(1), P. 31 - 42

Published: March 19, 2024

Diabetes is believed to be one of the most important challenges that are facing societies around world. The research was conducted determine effectiveness 150 mg/ml Spirulina platensis and 10 silver nanoparticles Ag-NPs on sugar level, lipid profile, liver enzyme concentration in male rats. induced with alloxan bred for four weeks. rats were divided randomly into five groups every single group contained rats; M1 control group, M2 a treated diabetic rat, M3 Ag-NPs, M4 S. M5 + platensis. results showed infected Alloxan (M2) caused negative effects at significant level (P<0.05) blood while (M3) or (M4) both (M5) positive effect glucose rate, which reached 292.6, 210.5, 199.3 mg/dl, respectively, compared 441.8 mg/dl. lipids diabetes an increase triglycerides (TG), cholesterol (TC), low-density lipoproteins (LDL), very (VLDL), decrease high-density (HDL). treatment M3, M4, improved significantly levels. same situation applied enzymes AST, ALT, ALP, whose values decreased (M3, M5) infection (M2).

Language: Английский

Citations

0
Role of Arthrospira Platensis in Preventing and Treating High-Fat Diet-Induced Hypercholesterolemia in Adult Rats DOI Open Access
Nunzio Antonio Cacciola, Paola De Cicco, Maja Milanović

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(12), P. 1827 - 1827

Published: June 11, 2024

Hyperlipidaemia is a recognised risk factor for cardiovascular disease. In this study, the antihyperlipidaemic properties of spirulina (Arthrospira platensis, strain S2 from Serbia) were tested in adult Wistar rats before and after induction hypercholesterolaemia by high-fat diet (HFD) to compare preventive with curative effect. Total cholesterol (TC), high-density lipoprotein (HDL-C), low-density (LDL-C), alanine transaminase (ALT) aspartate (AST) levels measured blood samples. The chemical composition (lipids, proteins cholesterol) content bile acids faeces animals also analysed. Feeding an atherogenic 10 weeks led successful development hyperlipidaemia, as serum TC LDL-C well lipids, animals’ significantly increased. Pre- post-treatment reduction LDL, ALT levels. Administration resulted both significant increase primary excretion decrease metabolism, pre-treatment being more effective than some cases. These results suggest that increased effect on gut microbiota may be mechanism responsible anti-hyperlipidaemic activity strain.

Language: Английский

Citations

0