Incomplete Immune Reconstitution and Traditional Chinese Medicine in Patients with HIV/AIDS: Challenges and Perspectives DOI Creative Commons

Xue Ding,

Leilei Fan,

Liran Xu

et al.

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 5827 - 5838

Published: Dec. 1, 2024

Antiretroviral therapy can reduce human immunodeficiency virus (HIV) load to undetectable levels and restore CD4+ T cells rebuild immune function in patients with HIV. However, some fail achieve reconstitution despite treatment. Traditional Chinese medicine is an important branch of complementary alternative for the treatment HIV infection, a growing number studies has demonstrated that traditional increase cell counts patients, thereby promoting reconstitution, ameliorating symptoms signs, improving quality life. Here, we review pathogenesis immunological non-responders research into their medicine. Furthermore, summarize potential future directions, including elucidation how regulate opportunistic infections improve life non-responders.

Language: Английский

Methamphetamine and HIV-1 Tat Synergistically Induce Microglial Pyroptosis Via Activation of the AIM2 Inflammasome DOI Creative Commons
Lin Miao,

Haowei Wang,

Xue Yang

et al.

Inflammation, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 19, 2025

Abstract Objective Human immunodeficiency virus (HIV)-infected individuals who abuse methamphetamine (METH) exhibit more severe neurotoxicity and cognitive impairment. Pyroptosis, a programmed cell death pathway mediated by the inflammasome, has been implicated in various neurological diseases. This study aimed to elucidate role of AIM2 inflammasome METH- HIV-1 Tat-induced pyroptosis human brain tissue vitro models. Methods Postmortem from HIV-infected with history METH was analyzed for markers components using immunohistochemistry, immunofluorescence, Western blotting. BV2 microglial cells were lentivirally transduced knockdown expression. DNA damage assessed blotting comet assay. Expression pyroptosis-related proteins evaluated electron microscopy, blotting, immunofluorescence. Cell viability measured CCK8 Results Elevated levels observed users. Tat synergistically induced time- concentration-dependent manner, accompanied activation inflammasome. Knockdown significantly reduced expression proteins. Conclusion induce activating through dsDNA damage. These findings suggest that targeting may be promising therapeutic strategy HIV-associated neurocognitive disorder (HAND). Graphical abstract

Language: Английский

Citations

1
Oridonin attenuates liver ischemia–reperfusion injury by suppressing PKM2/NLRP3-mediated macrophage pyroptosis DOI

Xin-yi Wu,

Minjie Zhao, Wei Liao

et al.

Cellular Immunology, Journal Year: 2024, Volume and Issue: 401-402, P. 104838 - 104838

Published: May 23, 2024

Language: Английский

Citations

4
Incomplete Immune Reconstitution and Traditional Chinese Medicine in Patients with HIV/AIDS: Challenges and Perspectives DOI Creative Commons

Xue Ding,

Leilei Fan,

Liran Xu

et al.

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 5827 - 5838

Published: Dec. 1, 2024

Antiretroviral therapy can reduce human immunodeficiency virus (HIV) load to undetectable levels and restore CD4+ T cells rebuild immune function in patients with HIV. However, some fail achieve reconstitution despite treatment. Traditional Chinese medicine is an important branch of complementary alternative for the treatment HIV infection, a growing number studies has demonstrated that traditional increase cell counts patients, thereby promoting reconstitution, ameliorating symptoms signs, improving quality life. Here, we review pathogenesis immunological non-responders research into their medicine. Furthermore, summarize potential future directions, including elucidation how regulate opportunistic infections improve life non-responders.

Language: Английский

Citations

0