In Vivo,
Journal Year:
2024,
Volume and Issue:
39(1), P. 201 - 209
Published: Dec. 31, 2024
Regulatory
T
cells
(Tregs)
play
a
crucial
role
in
inflammatory
responses
by
regulating
the
activity
of
various
immune
cells.
M2
macrophages
induced
IL-10
and
TGF-β
exhibit
anti-inflammatory
functions
induce
Treg
differentiation.
Although
beneficial
effects
3-bromo-4,5-dihydroxybenzaldehyde
(BDB)
on
diseases
have
been
widely
reported,
mechanisms,
through
which
it
alleviates
allergic
contact
dermatitis
(ACD)
via
Tregs
macrophages,
are
not
well
understood.
Therefore,
this
study
aimed
to
explore
whether
BDB
suppresses
ACD
induces
generation.
Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 2001 - 2001
Published: Dec. 4, 2024
Heart
failure
is
a
complex
syndrome
characterized
by
cardiac
hypertrophy,
fibrosis,
and
diastolic/systolic
dysfunction.
These
changes
share
many
pathological
features
with
significant
inflammatory
responses
in
the
myocardium.
Among
various
regulatory
systems
that
impact
on
these
heterogeneous
processes,
angiotensin
II
(Ang
II)-activated
macrophages
play
pivotal
role
induction
of
subcellular
defects
adverse
remodeling
during
progression
heart
failure.
Ang
stimulates
via
its
AT1
receptor
to
release
oxygen-free
radicals,
cytokines,
chemokines,
other
mediators
myocardium,
upregulates
expression
integrin
adhesion
molecules
both
monocytes
endothelial
cells,
leading
monocyte-endothelial
cell-cell
interactions.
The
transendothelial
migration
monocyte-derived
exerts
biological
effects
proliferation
fibroblasts,
deposition
extracellular
matrix
proteins,
perivascular/interstitial
development
hypertension,
hypertrophy
Inhibition
macrophage
activation
using
antagonist
or
depletion
from
peripheral
circulation
has
shown
inhibitory
II-induced
vascular
myocardial
injury.
purpose
this
review
discuss
current
understanding
maladaptive
dysfunction,
particularly
focusing
molecular
signaling
pathways
involved
macrophages-mediated
In
addition,
challenges
remained
translating
findings
treatment
patients
are
also
addressed.
Immunology and Cell Biology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 29, 2024
Abstract
Peritoneal
adhesion
(PA)
refers
to
the
abnormal
of
peritoneum
either
with
itself
or
tissues
and
organs
that
is
caused
by
abdominopelvic
surgery,
abdominal
infection
peritoneal
inflammation.
PA
associated
various
clinical
complications,
such
as
pain
distension,
intestinal
obstruction,
gastrointestinal
disorders
female
infertility,
adversely
affects
quality
life
patients.
Macrophages
are
essential
for
formation
can
undergo
polarization
into
classically
activated
macrophages
(M1)
alternatively
(M2),
which
influenced
microenvironment.
By
releasing
proinflammatory
cytokines
reactive
oxygen
species,
M1
promote
inflammatory
reactions
resultant
adhesion.
In
contrast,
M2
secrete
anti‐inflammatory
growth
factors
inhibit
repair
healing
tissues,
thereby
play
a
significant
role.
This
review
comprehensively
explores
function
mechanism
their
subtypes
in
gain
insight
prevention
treatment
based
on
modulation
macrophages.
Cells,
Journal Year:
2024,
Volume and Issue:
13(23), P. 1970 - 1970
Published: Nov. 28, 2024
Due
to
its
antimicrobial,
anti-inflammatory
and
pro-healing
properties,
the
application
of
cold
atmospheric
plasma
(CAP)
has
emerged
as
a
new
promising
therapeutic
strategy
in
various
fields
medicine,
including
general
medicine
dentistry.
In
this
light,
aim
present
study
was
investigate
effects
homemade
jet
on
cellular
behaviour
two
important
cell
types
involved
gingivitis,
namely
gingival
fibroblasts
(HGF-1
line)
macrophages
(RAW
264.7
line),
by
direct
CAP
different
experimental
conditions.
The
HGF-1
cells
investigated
terms
viability/proliferation
(LIVE/DEAD
CCK-8
assays),
morphological
features
(immunofluorescent
staining
actin
cytoskeleton)
fibronectin
expression
(immunocytochemical
network),
while
macrophages’
response
evaluated
through
assessment
survival/proliferation
rate
inflammatory
activity
(pro-inflammatory
cytokine
secretion
profile
(ELISA
assay)
foreign
body
giant
(FBGCs)
formation
cytoskeleton
multinuclearity
index
determination)).
vitro
biological
revealed
an
upward
trend
dependent
treatment
time
number
applications,
proliferation
(p
<
0.0001)
0.0001).
On
other
hand,
exposed
five
consecutive
applications
for
longer
times
(over
120
s)
exhibited
strong
pro-inflammatory
activity,
evinced
their
altered
morphology,
FBGCs
formation.
Overall,
our
results
demonstrate
that
exposure,
when
used
with
appropriate
operating
parameters,
beneficial
effect
RAW
cells,
thus
paving
way
further
vivo
investigations
will
allow
translation
from
research
clinic
alternative
therapy
gingivitis.
Expert Review of Clinical Immunology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 5, 2024
Introduction
In
recent
years,
immunotherapy
has
shown
significant
therapeutic
potential
in
patients
with
advanced
tumors.
However,
only
a
small
number
of
individuals
benefit,
mainly
due
to
the
tumor
microenvironment
(TME),
which
provides
conditions
for
development
Macrophages
TME,
known
as
tumor-associated
macrophages
(TAM),
are
divided
into
M1
anti-tumor
and
M2
pro-tumor
phenotypes,
play
regulatory
role
various
stages
tumorigenesis,
promote
tumorigenesis
metastasis,
cause
resistance.
In Vivo,
Journal Year:
2024,
Volume and Issue:
39(1), P. 201 - 209
Published: Dec. 31, 2024
Regulatory
T
cells
(Tregs)
play
a
crucial
role
in
inflammatory
responses
by
regulating
the
activity
of
various
immune
cells.
M2
macrophages
induced
IL-10
and
TGF-β
exhibit
anti-inflammatory
functions
induce
Treg
differentiation.
Although
beneficial
effects
3-bromo-4,5-dihydroxybenzaldehyde
(BDB)
on
diseases
have
been
widely
reported,
mechanisms,
through
which
it
alleviates
allergic
contact
dermatitis
(ACD)
via
Tregs
macrophages,
are
not
well
understood.
Therefore,
this
study
aimed
to
explore
whether
BDB
suppresses
ACD
induces
generation.
