Journal of Diabetes Research,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Diabetic
liver
injury
is
a
serious
complication
due
to
the
lack
of
effective
treatments
and
unclear
pathogenesis.
Ferroptosis,
form
cell
death
involving
reactive
oxygen
species
(ROS)-dependent
lipid
peroxidation
(LPO),
closely
linked
autophagy
diabetic
complications.
Therefore,
this
study
aimed
at
investigating
role
in
regulating
ferroptosis
by
modulating
degradation
acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
hepatocytes
its
potential
impact
on
injury.
Aging and Disease,
Journal Year:
2024,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2024
Aging
is
a
major
risk
factor
for
cardiovascular
diseases
(CVD),
and
mitochondrial
autophagy
impairment
considered
significant
physiological
change
associated
with
aging.
Endothelial
cells
play
crucial
role
in
maintaining
vascular
homeostasis
function,
participating
various
processes
such
as
regulating
tone,
coagulation,
angiogenesis,
inflammatory
responses.
As
aging
progresses,
endothelial
worsens,
leading
to
the
development
of
numerous
diseases.
Therefore,
vital
preventing
treating
age-related
However,
there
currently
lack
systematic
reviews
this
area.
To
address
gap,
we
have
written
review
provide
new
research
therapeutic
strategies
managing
Pharmacological Research,
Journal Year:
2024,
Volume and Issue:
208, P. 107383 - 107383
Published: Aug. 28, 2024
Mitochondria
exhibit
heterogeneous
shapes
and
networks
within
among
cell
types
tissues,
also
in
normal
or
osteoporotic
bone
tissues
with
complex
types.
This
dynamic
characteristic
is
determined
by
the
high
plasticity
provided
mitochondrial
dynamics
stemmed
from
responding
to
survival
functional
requirements
of
various
cells
a
specific
microenvironments.
In
contrast,
dysfunction,
induced
dysregulation
dynamics,
may
act
as
trigger
death
signals,
including
common
apoptosis
other
forms
programmed
(PCD).
These
PCD
processes
consisting
tightly
structured
cascade
gene
expression
events,
can
further
influence
remodeling
facilitating
cells.
Mitochondrial
therefore,
drive
stand
at
crossroads
life
integrating
external
signals
altering
metabolism,
shape,
signal-response
properties
mitochondria.
implies
that
targeting
displays
significant
potential
treatment
osteoporosis.
Considerable
effort
has
been
made
osteoporosis
emphasize
parallel
roles
mitochondria
regulating
energy
calcium
signal
transduction,
oxidative
stress,
inflammation,
death.
However,
emerging
field
dynamics-related
not
well
understood.
Herein,
bridge
gap,
we
outline
latest
knowledge
on
during
Journal of Diabetes Research,
Journal Year:
2024,
Volume and Issue:
2024(1)
Published: Jan. 1, 2024
Diabetic
liver
injury
is
a
serious
complication
due
to
the
lack
of
effective
treatments
and
unclear
pathogenesis.
Ferroptosis,
form
cell
death
involving
reactive
oxygen
species
(ROS)-dependent
lipid
peroxidation
(LPO),
closely
linked
autophagy
diabetic
complications.
Therefore,
this
study
aimed
at
investigating
role
in
regulating
ferroptosis
by
modulating
degradation
acyl-CoA
synthetase
long-chain
family
member
4
(ACSL4)
hepatocytes
its
potential
impact
on
injury.
