Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1474 - 1474
Published: Nov. 29, 2024
Bone
marrow
mesenchymal
stem
cells
(BM-MSCs)
play
a
crucial
role
in
bone
formation
through
their
ability
to
differentiate
into
osteoblasts.
Aging,
however,
detrimentally
affects
the
differentiation
and
proliferation
capacities
of
BM-MSCs,
consequently
impairing
regeneration.
Thus,
mitigating
aging
effects
on
BM-MSCs
is
vital
for
addressing
bone-related
pathologies.
In
this
study,
we
demonstrate
that
extracellular
nanovesicles
isolated
from
gold
kiwi
(GK-NVs)
protect
human
ultraviolet
(UV)-induced
photoaging,
thereby
alleviating
aging-related
impairments
cellular
functions
are
homeostasis.
Notably,
GK-NVs
were
efficiently
taken
up
by
without
causing
cytotoxicity.
reduced
intracellular
reactive
oxygen
species
(ROS)
levels
upon
UV
irradiation,
restoring
impaired
migration
capabilities.
Furthermore,
corrected
skewed
UV-irradiated
enhancing
osteoblast
differentiation,
as
evidenced
increased
expression
osteoblast-specific
genes
calcium
deposition,
reducing
adipocyte
indicated
decreased
lipid
droplet
formation.
These
findings
position
promising
biomaterial
treatment
diseases
such
osteoporosis.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 19, 2024
Abstract
Plastics
have
become
an
integral
part
of
human
life,
and
their
production
is
increasing
annually.
are
broken
down
into
small
particles
known
as
microplastics
(MPs)
with
particle
size
<
5
mm
in
the
environment
because
a
variety
factors.
MPs
prevalent
all
living
organisms
exposed
to
effects.
In
this
study,
we
investigated
whether
polystyrene
(PS)-MPs
were
transferred
from
cell-to-cell
via
extracellular
vesicles
(EVs).
This
study
showed
that
cell-derived
EVs
could
transport
plastic
particles.
addition,
using
real-time
imaging
device,
confirmed
PS-MPs
transported
by
accumulated
cells.
provides
understanding
potential
effects
on
suggests
directions
for
future
research.
MedComm,
Journal Year:
2024,
Volume and Issue:
5(12)
Published: Nov. 28, 2024
Abstract
Numerous
organisms
in
nature
have
demonstrated
enhanced
biocompatibility,
precise
tumor
targeting
capabilities,
and
efficient
tissue
traversal
within
the
human
body.
Drawing
inspiration
from
these
organisms,
researchers
employed
bioengineering,
bioconjugation,
micro‐
or
nanotechnology
to
fabricate
bioinspired
nanostructured
systems.
These
systems
play
a
crucial
role
addressing
limitations
of
conventional
anticancer
drugs
nanomaterials
concerning
effective
penetration
physiological
barriers,
as
well
selective
targeting,
thereby
leading
improved
therapeutic
efficacy
while
minimizing
nonspecific
adverse
effects
on
healthy
cells.
Consequently,
extensive
exploration
has
been
undertaken
across
various
cancer
treatment
modalities
with
some
progressing
into
preclinical
clinical
stages.
However,
our
understanding
this
field
remains
limited
which
may
impede
research
progress,
translation
efforts,
practical
applications.
Therefore,
study
presents
systematic
classification
for
therapy
that
comprehensively
elucidates
their
sources
design
principles.
Furthermore,
it
extensively
discusses
current
status
efforts
identifying
prevailing
challenges
exploring
future
prospects.
This
work
will
establish
robust
theoretical
framework
serve
valuable
reference
facilitate
advancements
application
field.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(12), P. 1474 - 1474
Published: Nov. 29, 2024
Bone
marrow
mesenchymal
stem
cells
(BM-MSCs)
play
a
crucial
role
in
bone
formation
through
their
ability
to
differentiate
into
osteoblasts.
Aging,
however,
detrimentally
affects
the
differentiation
and
proliferation
capacities
of
BM-MSCs,
consequently
impairing
regeneration.
Thus,
mitigating
aging
effects
on
BM-MSCs
is
vital
for
addressing
bone-related
pathologies.
In
this
study,
we
demonstrate
that
extracellular
nanovesicles
isolated
from
gold
kiwi
(GK-NVs)
protect
human
ultraviolet
(UV)-induced
photoaging,
thereby
alleviating
aging-related
impairments
cellular
functions
are
homeostasis.
Notably,
GK-NVs
were
efficiently
taken
up
by
without
causing
cytotoxicity.
reduced
intracellular
reactive
oxygen
species
(ROS)
levels
upon
UV
irradiation,
restoring
impaired
migration
capabilities.
Furthermore,
corrected
skewed
UV-irradiated
enhancing
osteoblast
differentiation,
as
evidenced
increased
expression
osteoblast-specific
genes
calcium
deposition,
reducing
adipocyte
indicated
decreased
lipid
droplet
formation.
These
findings
position
promising
biomaterial
treatment
diseases
such
osteoporosis.
