Deleted Journal,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
Abstract
Plant
extracellular
vesicles
(PEVs)
are
nanoscale
secreted
by
plant
cells
with
intact
membrane
architecture,
which
encapsulate
a
diverse
array
of
biomolecules,
including
lipids,
proteins
and
RNA.
They
integral
to
both
intra‐cellular
communication
within
plants
inter‐species
signaling.
Recently,
some
PEVs
have
been
regarded
as
competitive
candidates
for
disease
therapy
due
their
beneficial
components
distinctive
hollow
biomembrane
structure.
However,
the
broader
applications
currently
impeded
several
challenges
complicated
extraction
processes,
compositional
heterogeneity,
lack
reliable
biomarkers
unclear
mechanisms.
A
detailed
comprehension
preparation
techniques
biological
functions
is
essential
leveraging
potential
in
clinical
medicine.
This
article
first
presented
synthesis
current
methodologies
PEV
isolation,
purification
characterization.
Then,
it
revealed
therapeutic
implications
medicines
common
diseases
based
on
bioactive
molecules
inside,
such
cancer,
inflammation,
metabolic
disorders.
We
especially
explored
emerging
role
low
immunogenicity
power
barriers
crossing
drug
delivery
systems,
underscoring
further
industry
applications.
At
last,
bottleneck
problems
vision
were
also
evoke
more
insightful
deliberation.
review
aims
provide
directions
development
PEV‐derived
innovative
drugs.
Genes,
Journal Year:
2025,
Volume and Issue:
16(2), P. 208 - 208
Published: Feb. 8, 2025
It
is
widely
known
that
the
dysregulation
of
non-coding
RNAs
(ncRNAs)
and
dysbiosis
gut
microbiome
play
significant
roles
in
host
development
progression
various
diseases.
Emerging
evidence
has
highlighted
bidirectional
interplay
between
ncRNAs
microbiome.
This
article
aims
to
review
current
understanding
molecular
mechanisms
underlying
crosstalk
ncRNAs,
especially
microRNA
(miRNA),
context
diseases,
such
as
colorectal
cancer,
inflammatory
bowel
neurological
disorders,
obesity,
cardiovascular
disease.
Ultimately,
this
seeks
provide
a
foundation
for
exploring
potential
interactions
biomarkers
therapeutic
targets
clinical
diagnosis
treatment,
ncRNA
mimics,
antisense
oligonucleotides,
small-molecule
compounds,
well
probiotics,
prebiotics,
diets.
Microbiome Research Reports,
Journal Year:
2025,
Volume and Issue:
4(1)
Published: Feb. 21, 2025
MicroRNAs
(miRNAs)
are
short,
non-coding
RNAs
that
play
gene
expression
regulatory
roles
in
eukaryotes.
MiRNAs
also
released
body
fluids,
and
the
intestine,
they
found
lumen
feces.
Here,
together
with
exogenous
dietary-derived
miRNAs,
constitute
fecal
miRNome.
Several
miRNAs
were
identified
feces
of
healthy
adults,
including,
as
shown
here,
core
hsa-miR-21-5p
hsa-miR-1246.
These
important
for
intestinal
homeostasis.
Recent
evidence
suggests
may
interact
gut
bacteria.
This
represents
a
new
avenue
to
understand
host-bacteria
crosstalk
its
role
health
disease.
review
provides
comprehensive
overview
current
knowledge
on
their
representation
across
individuals,
effects
microbiota.
It
discusses
existing
potential
mechanisms
uptake
interaction
bacterial
genomes,
drawing
from
prokaryotic
small
(sRNAs)
regulation
expression.
Finally,
we
silico
experimental
approaches
profiling
miRNA-mRNA
interactions
species,
highlighting
challenges
target
validation.
work
emphasizes
need
further
research
into
host
miRNA-bacterial
better
ecosystem
support
exploitation
disease
prevention
treatment.
Current Issues in Molecular Biology,
Journal Year:
2025,
Volume and Issue:
47(3), P. 144 - 144
Published: Feb. 22, 2025
Exosome-like
nanovesicles
(ELNs)
derived
from
natural
products
are
gaining
attention
as
innovative
therapeutic
agents
due
to
their
biocompatibility,
low
immunogenicity,
and
capability
transport
bioactive
molecules
such
proteins,
lipids,
nucleic
acids.
These
plant-derived
ELNs
exhibit
structural
similarities
with
mammalian
exosomes,
making
them
suitable
for
drug
delivery,
microbiome-targeted
therapies,
regenerative
medicine.
Recent
studies
highlight
potential
in
treating
cancer,
inflammation,
metabolic
disorders.
Additionally,
have
applications
cosmetics,
agriculture,
the
food
industry.
This
review
combines
latest
advancements
research
on
ELNs,
focusing
isolation
techniques,
pharmacological
effects,
applications.
Although
offer
promising
opportunities,
several
challenges
must
be
addressed,
including
standardization,
large-scale
production,
vivo
efficacy.
By
summarizing
cutting-edge
suggesting
future
directions,
we
aim
inspire
further
development
of
next-generation
platforms.
Critical Reviews in Food Science and Nutrition,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 19
Published: Aug. 11, 2024
Recent
decades
have
witnessed
substantial
interest
in
extracellular
vesicles
(EVs)
due
to
their
crucial
role
intercellular
communication
across
various
biological
processes.
Among
these,
plant-derived
exosome-like
Nanoparticles
(ELNs)
rapidly
gained
recognition
as
highly
promising
candidates.
ELNs,
characterized
by
diverse
sources,
cost-effective
production,
and
straightforward
isolation,
present
a
viable
option
for
preventing
treating
numerous
diseases.
Furthermore,
ELNs
hold
significant
potential
carriers
natural
or
engineered
drugs,
enhancing
attractiveness
drawing
considerable
attention
science
medicine.
However,
translating
into
clinical
applications
poses
several
challenges.
This
study
explores
these
challenges
offers
critical
insights
research
directions.
Additionally,
it
provides
forward-looking
analysis
of
the
industrial
prospects
ELNs.
With
broad
remarkable
potential,
stand
at
forefront
biomedical
innovation,
poised
revolutionize
disease
management
drug
delivery
paradigms
coming
years.
