Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 16, 2024
Language: Английский
Cytokine & Growth Factor Reviews, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
1
Angewandte Chemie International Edition, Journal Year: 2024, Volume and Issue: 63(49)
Published: Aug. 24, 2024
Abstract The integration of pyroptosis and ferroptosis hybrid cell death induction to augment immune activation represents a promising avenue for anti‐tumor treatment, but there is lack research. Herein, we developed two iridium (III)‐triphenylamine photosensitizers, IrC IrF , with the capacity disrupt redox balance induce photo‐driven cascade damage DNA Kelch‐like ECH‐associated protein 1 (KEAP1). absent in melanoma 2 (AIM2)‐related cytoplasmic nucleic acid‐sensing pathway, triggered by damaged DNA, leads gasdermin D (GSDMD)‐mediated pyroptosis. Simultaneously, iron homeostasis, regulated KEAP1/nuclear factor erythroid 2‐related (NRF2)/heme oxygenase (HO‐1) serves as pivotal bridge, facilitating not only E (GSDME)‐mediated non‐canonical pyroptosis, also synergy glutathione peroxidase 4 (GPX4) depletion. collaborative action generates synergistic effect that elicits immunogenic death, stimulates robust response effectively inhibits tumor growth vivo. Our work introduces first metal‐based small molecule dual‐inducers potent cancer immunotherapy, highlights significance homeostasis vital hub connecting effects ferroptosis.
Language: Английский
Citations
6
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 306, P. 141816 - 141816
Published: March 6, 2025
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 141, P. 113006 - 113006
Published: Aug. 29, 2024
Pyroptosis, a newly identified form of programmed cell death intertwined with inflammatory responses, is facilitated by the Gasdermin family's pore-forming activity, leading to lysis and release pro-inflammatory cytokines. This process double-edged sword in innate immunity, offering protection against pathogens while risking excessive inflammation tissue damage when dysregulated. Specifically, pyroptosis operates through two distinct signaling pathways, namely Caspase-1 pathway Caspase-4/5/11 pathway. In context chronic liver diseases like fibrosis cirrhosis, emerges as central contributing factor their pathogenesis. The identification characterized activation immune cells secretion cytokines such IL-1α, IL-1β, TNF-α. review explores interrelationship between inflammasome, protein complex located that recognizes danger signals initiates activation, resulting IL-1β IL-18. article delves into influence inflammasome on various disorders, specific focus molecular pathophysiological mechanisms. Additionally, potential therapeutic implications targeting for are highlighted future consideration.
Language: Английский
Citations
3
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 3, 2024
Oxidative stress and the accompanying chronic inflammation constitute an important metabolic problem that may lead to pathology, especially when body is exposed physicochemical biological factors, including UV radiation, pathogens, drugs, as well endogenous disorders. The cellular response associated, among others, with changes in lipid metabolism, mainly due oxidation action of lipolytic enzymes. Products oxidative fragmentation/cyclization polyunsaturated fatty acids (PUFAs) [4-HNE, MDA, 8-isoprostanes, neuroprostanes] eicosanoids generated a result enzymatic metabolism PUFAs significantly modify functioning immune system by interfering intracellular molecular signaling. key regulators inflammation, effectiveness which can be regulated interacting products under stress, are inflammasome complexes. An example both negative or positive regulation NLRP3 activity 4-HNE depending on severity stress. modifies direct interaction alteration NF-κB Furthermore, prostaglandin E2 known positively correlated NLRC4 activity, while its potential interference AIM2 NLRP1 unproven. Therefore, influence PUFA metabolites well-characterized complexes reviewed.
Language: Английский
Citations
3
Advances in Virology, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
Programmed cell death (PCD) is a well‐studied cellular mechanism that plays critical role in immune responses, developmental processes, and the maintenance of tissue homeostasis. However, viruses have developed diverse strategies to bypass or manipulate host apoptotic machinery enhance their replication survival. As result, interaction between PCD pathways has garnered increased interest, leading many studies being published recent years. This study aims provide an overview current understanding significance viral infections. We will discuss various forms pathways, including apoptosis, autophagy, necroptosis, pyroptosis, as well corresponding molecular mechanisms. In addition, we show how prevent delay facilitate replication. emphasizes importance investigating mechanisms by which control host’s gain insight into evolutionary dynamics host‐pathogen interactions develop new approaches for predicting managing threats. Overall, aimed highlight research areas viruses, introduction targets development antiviral drugs modulate novel inhibitors pathways.
Language: Английский
Citations
0
APOPTOSIS, Journal Year: 2025, Volume and Issue: unknown
Published: April 26, 2025
PANoptosis is a newly discovered cell death pathway triggered by the innate immunizer, which in turn promotes assembly of PANoptosome and activates downstream effectors. As special mode, it characterized apoptosis, pyroptosis, necroptosis at same time; therefore, not feasible to inhibit suppressing single pathway. However, active ingredients targeting can effectively PANoptosis.Given importance disease, would be an important therapeutic tool. Previous studies have focused more on infectious diseases cancer, role cardiovascular field has been comprehensively addressed. While ASCVD number one killer diseases, explore new targets determine future research directions. Therefore, this review focuses PANoptosome, molecular mechanism PANoptosis, related mechanisms leading such as myocardial infarction, ischemic cardiomyopathy stroke, order provide perspective for prevention treatment ASCVD.
Language: Английский
Citations
0
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: April 28, 2025
Fungal immunomodulatory proteins (FIPs) are small from fungi with considerable activity. FIP-nha ( Nectria haematococca ) contains two glycosylation sites at positions N5 and N39, displays a high thermostability notable anti-tumour However, FIP-nha’s activity on macrophages the associated mechanism remain unclear. In this study, three rFIP-nha glycan mutants (N5A, N39A, N5+39A) were recombinantly expressed in Pichia pastoris . To test impact activity, phagocytotic cytokine secretion, gene expression of THP-1 investigated. its reduced macrophage phagocytosis, induced IL-1β, IL-12 IL-10 secretion significantly, indicating that protein confers pro-inflammatory behaviour macrophages. there no obvious differences among different mutants, observed activation mechanisms likely glycosylation-independent. Furthermore, to study mechanism, four kinds inflammasomes (NLRP1, NLRP3, NLRC4 AIM2) tested transcriptional level. AIM2 was found be 10-fold upregulated. Then, THP1-KO-ASC cells related inhibitors showed IL-1β release by is ASC signalling pathway dependent. Taken together, these findings suggest activates way activating inflammasome.
Language: Английский
Citations
0
Extracellular Vesicles and Circulating Nucleic Acids, Journal Year: 2024, Volume and Issue: 5(2), P. 297 - 328
Published: June 18, 2024
Host-bacteria and bacteria-bacteria interactions can be facilitated by extracellular vesicles (EVs) secreted both human bacterial cells. Human EVs (BEVs) propagate transfer immunogenic cargos that may elicit immune responses in nearby or distant recipient cells/tissues. Hence, direct colonization of tissues cells is not required for stimulation. This phenomenon important the feto-maternal interface, where optimum tolerance between mother fetus a successful pregnancy. Though intrauterine cavity widely considered sterile, BEVs from diverse sources have been identified placenta amniotic cavity. These internalized cells, which help them evade host surveillance. it appears logical, whether internalize EV cargo yet to determined. However, presence placental believed trigger low-grade response primes fetal system ex-utero survival, but insufficient disrupt progression pregnancy cause intolerance adverse events. Nevertheless, exchange bioactive BEVs, mechanical underpinnings health implications such interactions, especially during pregnancy, are still understudied. Therefore, while focusing on we discussed how take up their cargo, cell (feto-maternal) inflammatory BEV stimulation, associations these with priming reproductive outcomes as preeclampsia preterm birth.
Language: Английский
Citations
2
Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(49)
Published: Aug. 24, 2024
Abstract The integration of pyroptosis and ferroptosis hybrid cell death induction to augment immune activation represents a promising avenue for anti‐tumor treatment, but there is lack research. Herein, we developed two iridium (III)‐triphenylamine photosensitizers, IrC IrF , with the capacity disrupt redox balance induce photo‐driven cascade damage DNA Kelch‐like ECH‐associated protein 1 (KEAP1). absent in melanoma 2 (AIM2)‐related cytoplasmic nucleic acid‐sensing pathway, triggered by damaged DNA, leads gasdermin D (GSDMD)‐mediated pyroptosis. Simultaneously, iron homeostasis, regulated KEAP1/nuclear factor erythroid 2‐related (NRF2)/heme oxygenase (HO‐1) serves as pivotal bridge, facilitating not only E (GSDME)‐mediated non‐canonical pyroptosis, also synergy glutathione peroxidase 4 (GPX4) depletion. collaborative action generates synergistic effect that elicits immunogenic death, stimulates robust response effectively inhibits tumor growth vivo. Our work introduces first metal‐based small molecule dual‐inducers potent cancer immunotherapy, highlights significance homeostasis vital hub connecting effects ferroptosis.
Language: Английский
Citations
1