Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
Renal Failure, Journal Year: 2025, Volume and Issue: 47(1)
Published: Jan. 13, 2025
Copper is a vital cofactor in various enzymes, plays pivotal role maintaining cell homeostasis. When copper metabolism disordered and mitochondrial dysfunction impaired, programmed death such as apoptosis, paraptosis, pyroptosis, ferroptosis, cuproptosis, autophagy necroptosis can be induced. In this review, we focus on the metabolic mechanisms of copper. addition, discuss mechanism by which induces deaths. Finally, review examines copper's involvement prevalent kidney diseases acute injury chronic disease. The findings indicate that use chelators or plant extracts mitigate damage reducing accumulation, offering novel insights into pathogenesis treatment strategies for diseases.
Language: Английский
Citations
1
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Feb. 24, 2025
Periodontitis is a significant global public health issue associated with the onset and progression of various systemic diseases, thereby requiring additional research clinical attention. Although ferroptosis cuproptosis have emerged as areas in medical field, their precise roles pathogenesis periodontitis remain unclear. We aim to systematically summarize current on periodontal disease investigate glutathione pathway autophagy connecting during periodontitis. Further, we propose that homeostatic imbalance copper iron, driven by pathogens, may contribute elevated oxidative stress, representing potential unifying link between involved This article presents comprehensive overview molecular mechanisms underlying periodontitis, offering novel theoretical insights into its therapeutic targets.
Language: Английский
Citations
1
Redox Biology, Journal Year: 2024, Volume and Issue: 76, P. 103315 - 103315
Published: Aug. 15, 2024
Testicular aging manifests as impaired spermatogenesis and morphological alterations in Drosophila. Nonetheless, the comprehensive molecular regulatory framework remains largely undisclosed. This investigation illustrates impact of copper overload on testicular underscores interplay between lncRNA. Copper triggers Cuproptosis through mitochondrial TCA cycle, facilitating intracellular interactions with Ferroptosis, thereby governing aging. Dysfunction lncRNA:CR43306 also contributes to Drosophila, emphasizing significance a novel aging-associated Moreover, exacerbates spermatid differentiation defects mediated by deficiency oxidative stress, copper, iron transport. Therapeutically, Ferrostatin-1 Resveratrol emerge potential remedies for addressing study offers perspectives mechanisms involving context
Language: Английский
Citations
5
Toxics, Journal Year: 2025, Volume and Issue: 13(1), P. 55 - 55
Published: Jan. 14, 2025
Background: While current epidemiological studies have documented associations between environmental metals and renal dysfunction, the majority concentrated on plasma metal levels. The relationship urinary exposure chronic kidney disease (CKD) remains contentious, particularly within specific demographic groups. Methods: This cross-sectional study included 2919 rural Chinese adults recruited 2018 2019. Urine were measured by ICP-MS. Least absolute shrinkage selection operator (LASSO) regression was employed to identify significantly associated with CKD. Then, we used binary logistic regression, along restricted cubic spline (RCS) models, assess individual effects of Quantile g-computation, weighted quantile sum Bayesian kernel machine (BKMR) models applied evaluate combined exposures Gender-stratified analyses also conducted explore these associations. Results: LASSO identified seven (V, Cu, Rb, Sr, Ba, W, Pb) significant impacts In single-metal Cu W exhibited a positive correlation CKD, whereas V, Pb showed negative correlations (all p < 0.05). RCS analysis revealed nonlinear Pb, CKD p-nonlinear multi-metal model, quantile-based g-computation demonstrated collective association risk for mixed (OR (95% CI) = −0.430 (−0.656, −0.204); 0.001), contributing this effect. WQS model further confirmed joint CI): −0.885 (−1.083, −0.899); V as main contributor. BKMR indicated an overall impact mixture risk. Interactions may exist well Sr Pb. female subgroup in consistency association. Conclusions: Our findings demonstrate risk, notable females. Joint multiple involve synergistic or antagonistic interactions influencing function. Further research is needed validate observations elucidate underlying mechanisms.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: Jan. 23, 2025
Ferroptosis is a novel form of cell death distinct from traditional mechanisms, characterized by the accumulation iron ions and production lipid peroxides. It not only affects survival tumor cells but also closely linked to changes in microenvironment. Lung cancer one leading malignancies worldwide terms incidence mortality, its complex biological mechanisms resistance make treatment challenging. Recent studies have shown that ferroptosis plays key role onset progression lung cancer, with intricate regulatory influencing development response therapy. As research into deepens, related molecular pathways, such as glutamate metabolism, antioxidant defense, been gradually revealed. However, clinical practice, ferroptosis-based therapeutic strategies for are still their early stages. Challenges remain, including incomplete understanding specific ferroptosis, insufficient on factors, limited insight interactions within Therefore, effective modulation enhance remains an urgent issue. This review summarizes analyzes factors interaction microenvironment, further explores potential targeting ferroptosis. By synthesizing latest research, this paper aims provide new perspectives directions treatment, goal advancing applications.
Language: Английский
Citations
0
Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1609 - 1626
Published: March 1, 2025
Purpose: Vaccarin is a natural flavonoid glycoside with anti-inflammatory, antioxidant and nephroprotective effects. However, the effects of vaccarin on renal fibrosis (RF) its molecular mechanisms remain unclear. This study aimed to investigate RF mechanisms. Methods: Network pharmacology was used analyze effect RF, docking dynamics simulations were performed assess binding nuclear factor erythroid 2-related 2 (Nrf2) vaccarin. A mouse model unilateral ureteral obstruction (UUO) established in vivo, human tubular epithelial (HK2) cells induced transforming growth factor-β (TGF-β) RSL3, respectively, as an vitro model. The anti-fibrotic observed by histopathological staining determination fibrous markers. Changes oxidative stress ferroptosis-related markers detected kits, Western blot (WB), qRT-PCR immunofluorescence (IF). Finally, Nrf2 inhibitors added observe ferroptosis. Results: cross genes are enriched for stress. binds stably Both vivo experiments showed that treatment reduced expression markers, decreased levels reactive oxygen species (ROS), malondialdehyde (MDA), lipid peroxidation (LPO) Fe 2+ , increased glutathione (GSH) secretion. In addition, down-regulated Long-chain acyl-CoA synthetase 4 (ACSL4), prostaglandin-endoperoxide synthase (PTGS2) NADPH oxidase 1 (NOX1), up-regulated downstream solute transport family 7 member 11 (SLC7A11) peroxidase (GPX4) expression. Mechanistic studies indicated activated Nrf2/SLC7A11/GPX4 pathway inhibit ferroptosis, this inhibition effectively reversed inhibitor. Conclusion: ameliorates inhibiting ferroptosis via pathway. Keywords: vaccarin, fibrosis, pathway, stress, network
Language: Английский
Citations
0
Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 15, 2025
Elevated copper levels induce tumor cuproptosis and ferroptosis, leading to immunogenic cell death subsequent antitumor immune responses. However, dysregulated metabolism in cells maintains homeostatic balance, while hypoxic microenvironments hinder therapeutic efficacy. In this study, we present a nanozyme system, termed CussOMEp, comprising copper-based nanovector (CussNV) that is PEGylated loaded with omeprazole, transporter inhibitor, enhance synergistic immunotherapy by promoting ferroptosis. CussNV assembled from dithiodiglycolic acid ions, exhibiting peroxidase, glutathione oxidase, catalase-like activities, along responsive degradability. This alleviates hypoxia producing oxygen, induces ferroptosis through the generation of lethal hydroxyl radicals, depletes glutathione. Additionally, omeprazole increases cellular concentration oxidative stress inhibiting intracellular copper-transporting ATPase 1 (ATP7A), enhancing lipoylated protein oligomerization cuproptosis. breast mouse model, CussOMEp elicits robust responses, including dendritic maturation T proliferation. When combined PD-1 antibodies (αPD-1), significantly inhibits metastasis bilateral lung metastatic models. work presents functional system as promising strategy for leveraging
Language: Английский
Citations
0
Advanced Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 9, 2025
Abstract Ferroptosis, as novel type of regulated cell death that has garnered widespread attention over the past decade, witnessed continuous discovery an increasing number regulatory mechanisms. Trace metal elements play a multifaceted and crucial role in oncology. Interestingly, it been increasingly evident these elements, such copper, are involved regulation iron accumulation, lipid peroxidation antiferroptotic systems, suggesting existence “nonferrous” mechanisms ferroptosis. In this review, comprehensive overview composition mechanism ferroptosis is provided. The interaction between copper metabolism (including cuproptosis) cancer, well roles other trace (such zinc, manganese, cobalt, molybdenum) specifically focused. Furthermore, applications nanomaterials based on metals cancer therapy also reviewed potential strategies for co‐targeting cuproptosis explored. Nevertheless, light intricate ambiguous nature interactions, ongoing research essential to further elucidate ferroptosis, thereby facilitating development therapeutic targets approaches treatment.
Language: Английский
Citations
0
Cellular Signalling, Journal Year: 2025, Volume and Issue: 132, P. 111839 - 111839
Published: April 28, 2025
Language: Английский
Citations
0
Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский
Citations
0