Advancements in Clinical Research and Emerging Therapies for Triple-Negative Breast Cancer Treatment DOI
Lili Xu, Pengtao Xu, Jingsong Wang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177202 - 177202

Published: Dec. 1, 2024

Language: Английский

Histone Lysine Crotonylation Accelerates ACSL4-Mediated Ferroptosis of Keratinocytes via Modulating Autophagy in Diabetic Wound Healing DOI Creative Commons
Fengjuan Li,

Haowen Ye,

Lanlan Li

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107632 - 107632

Published: Jan. 1, 2025

Language: Английский

Citations

0
HDL cholesterol esters mediate the genetic link between sedentary behavior and urological cancers: Insights from mediation and validation analyses DOI Creative Commons
Junhao Chen, Junxian Zhao,

Jieming Zuo

et al.

Medicine, Journal Year: 2025, Volume and Issue: 104(18), P. e42369 - e42369

Published: May 2, 2025

This study explores the causal relationship between sedentary behavior and urological cancers, focusing on bladder cancer (BC), prostate cancer, kidney using Bayesian Mendelian randomization mediation analysis. A two-sample (MR) framework was employed, genetic variants as instrumental variables. multivariate MR assessed effects of behaviors (TV watching, computer use, driving) cancers. Sensitivity analyses (MR-Egger, MR-PRESSO, Cochran Q ) ensured robustness. Mediation analysis identified high-density lipoprotein (HDL) cholesterol ester levels a primary mediator, validated through meta-analysis. Prolonged TV watching significantly associated with increased BC risk (OR = 2.908; 95% CI 1.221–6.930; P .015). showed small HDL mediated 17.5% this effect. No relationships were observed use or driving confirmed robust findings without heterogeneity pleiotropy. increases risk, by levels. Sedentary is modifiable factor, highlighting importance lifestyle interventions in prevention.

Language: Английский

Citations

0
Nrf2 inhibition and NCOA4-mediated ferritinophagy activation synergistically exacerbated S-3’-hydroxy-7’, 2’, 4’-trimethoxyisoxane induced ferroptosis in lung cancer cells DOI
Jiaxin Liu, Songlin Zhou, Jing Chen

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: unknown, P. 111353 - 111353

Published: Dec. 1, 2024

Language: Английский

Citations

2
Advancements in Clinical Research and Emerging Therapies for Triple-Negative Breast Cancer Treatment DOI
Lili Xu, Pengtao Xu, Jingsong Wang

et al.

European Journal of Pharmacology, Journal Year: 2024, Volume and Issue: unknown, P. 177202 - 177202

Published: Dec. 1, 2024

Language: Английский

Citations

1