ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(4), P. 525 - 534
Published: July 1, 2024
Language: Английский
Published: Jan. 1, 2025
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(2)
Published: Jan. 24, 2025
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2024, Volume and Issue: 206, P. 107268 - 107268
Published: June 20, 2024
Heart failure (HF) has emerged as the most pressing health concerns globally, and extant clinical therapies are accompanied by side effects patients have a high burden of financial. The protein products nuclear factor erythroid 2-related 2 (Nrf2) target genes variety cardioprotective effects, including antioxidant, metabolic functions anti-inflammatory. By evaluating established preclinical research in HF to date, we explored potential Nrf2 exert unique novel therapeutic receptor for HF. In this review, generalize progression, structure, function cardiovascular system. mechanism action involved well agonists natural compounds summarized. Additionally, discuss challenges implications future translation application pharmacology targeting Nrf2. It's critical developing new drugs
Language: Английский
Citations
2
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 142, P. 113194 - 113194
Published: Sept. 20, 2024
Language: Английский
Citations
2
PLoS ONE, Journal Year: 2024, Volume and Issue: 19(9), P. e0310843 - e0310843
Published: Sept. 30, 2024
Clear cell renal carcinoma (ccRCC) is the most prevalent subtype of kidney cancer. Although there increasing evidence linking ccRCC to genetic alterations, exact molecular mechanism behind this relationship not yet completely known researchers. Though drug therapies are best choice after metastasis, unfortunately, majority patients progressively develop resistance against therapeutic drugs receiving it for almost 2 years. In case, multi-targeted different variants essential effective treatment ccRCC. To understand mechanisms development and progression, explore drugs, identify ccRCC-causing key genes (KGs). order obtain KGs, at first, we detected 133 common differentially expressed (cDEGs) between control samples based on nine (9) microarray gene-expression datasets with NCBI accession IDs GSE16441, GSE53757, GSE66270, GSE66272, GSE16449, GSE76351, GSE66271, GSE71963, GSE36895. Then, filtered these cDEGs through survival analysis independent TCGA GTEx database obtained 54 scDEGs having significant prognostic power. Next, used protein-protein interaction (PPI) network reduced set top-ranked eight KGs ( PLG , ENO2 ALDOB UMOD ALDH6A1 SLC12A3 SLC12A1 SERPINA5 ). The pan-cancer showed association subtypes cancers including gene regulatory (GRN) revealed some crucial transcriptional post-transcriptional regulators KGs. scDEGs-set enrichment significantly identified functions, biological processes, cellular components, pathways that linked results DNA methylation study indicated hypomethylation hyper-methylation which may lead immune infiltrating types (CD8+ T CD4+ cell, B neutrophil, dendritic macrophage) their in ccRCC, where positively correlated cells, but negatively other supported by literature review also. Then 10 repurposable molecules (Irinotecan, Imatinib, Telaglenastat, Olaparib, RG-4733, Sorafenib, Sitravatinib, Cabozantinib, Abemaciclib, Dovitinib.) docking KGs-mediated receptor proteins. Their ADME/T cross-validation receptors, also potent Therefore, outputs might be useful inputs/resources wet-lab researchers clinicians considering an strategy
Language: Английский
Citations
2
ONCOLOGIE, Journal Year: 2024, Volume and Issue: 26(4), P. 525 - 534
Published: July 1, 2024
Language: Английский
Citations
0