Organismal mucosal immunology: A perspective through the eyes of game theory DOI Creative Commons
Eduardo J. Villablanca

Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specialized cell exposed constant environmental challenges. Understanding how homeostasis at is maintained and its disruption can lead autoimmune diseases or cancer, requires a holistic view. Although omics approaches systems immunology have become powerful tools, they are not without limitations; interpretations may reflect researchers' assumptions, even if other explanations exist. this perspective, I propose applying game theory concepts could help interpret data, offering fresh perspectives supporting the exploration of alternative scenarios. By framing immune system as network strategic interactions with multiple possible outcomes, theory, which analyzes decision-making processes, illuminate novel types functions, interactions, responses pathogens commensals, leading more comprehensive understanding diseases. addition, might encourage researchers consider broader range possibilities, reduce risk myopic thinking, ultimately enable refined complexity barriers. This perspective aims introduce complementary framework for immunologists, encouraging them incorporate these into data interpretation modeling.

Language: Английский

PIM1 signaling in immunoinflammatory diseases: an emerging therapeutic target DOI Creative Commons
Xue Yang, Chunming Liu, Yuxi Lei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Sept. 20, 2024

PIM1, the proviral integration site for Moloney murine leukemia virus, is a member of serine/threonine protein kinase family. It involved in many biological events, such as cell survival, cycle progression, proliferation, and migration, has been widely studied malignant diseases. However, recent studies have shown that PIM1 plays prominent role immunoinflammatory diseases, including autoimmune uveitis, inflammatory bowel disease, asthma, rheumatoid arthritis. can function signal transduction by phosphorylating multiple substrates mediating macrophage activation T lymphocyte specification, thus participating development Moreover, inhibition demonstrated to ameliorate certain disorders. Based on these studies, we suggest potential therapeutic target diseases valid candidate future research. Herein, first time, provide detailed review focuses roles pathogenesis

Language: Английский

Citations

0
Organismal mucosal immunology: A perspective through the eyes of game theory DOI Creative Commons
Eduardo J. Villablanca

Mucosal Immunology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

In complex organisms, functional units must interact cohesively to maintain homeostasis, especially within mucosal barriers that house diverse, specialized cell exposed constant environmental challenges. Understanding how homeostasis at is maintained and its disruption can lead autoimmune diseases or cancer, requires a holistic view. Although omics approaches systems immunology have become powerful tools, they are not without limitations; interpretations may reflect researchers' assumptions, even if other explanations exist. this perspective, I propose applying game theory concepts could help interpret data, offering fresh perspectives supporting the exploration of alternative scenarios. By framing immune system as network strategic interactions with multiple possible outcomes, theory, which analyzes decision-making processes, illuminate novel types functions, interactions, responses pathogens commensals, leading more comprehensive understanding diseases. addition, might encourage researchers consider broader range possibilities, reduce risk myopic thinking, ultimately enable refined complexity barriers. This perspective aims introduce complementary framework for immunologists, encouraging them incorporate these into data interpretation modeling.

Language: Английский

Citations

0