Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1 DOI Creative Commons
Biao Kuang,

Nana Geng,

Yi Miao

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Ginsenoside Rg1: A bioactive therapeutic agent for diverse liver diseases DOI Creative Commons

Ming‐Kung Wu,

Ke Li,

Jiabin Wu

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107571 - 107571

Published: Jan. 1, 2025

Diverse liver diseases are characterised by late diagnosis and rapid progression have become one of the major threats to human health. To delay transition from benign tissue lesions a substantial organ injury, scientists gradually applied natural compounds derived plants as complementary therapy in field hepatology. Ginseng (Panax ginseng C. A. Meyer) is tonic traditional Chinese herbal medicine, products, including ginsenoside Rg1 (G-Rg1), which kind 20(S)-protopanaxatriol saponin with relatively high biological activity, can be isolated roots or stems ginseng. Given these information, this review aimed summarise discuss metabolic mechanisms G-Rg1 regulation diverse measures improve its bioavailability. As monomer medicine multitarget pharmacological effects, provide significant therapeutic benefits alleviation alcoholic disease, nonalcoholic fatty fibrosis, viral hepatitis, etc., mainly rely on inhibition apoptosis, strengthening endogenous anti-inflammatory antioxidant mechanisms, activation immune responses efflux transport signals, pathological changes caused lipid deposition, inflammation, oxidative stress, accumulation hepatotoxic product, etc. However, poor bioavailability must overcome clinical application value. In summary, focusing hepatoprotective will new insights into development resources their pharmaceutical products target treatment diseases.

Language: Английский

Citations

0
The Special Issue “The 20th Anniversary of Pharmaceuticals—Multi-Targeted Natural Products as Therapeutics” Editorial—Multi-Targeted Therapeutics from Natural Sources: What Do We Know? DOI Creative Commons
Elena Y. Enioutina, Kathleen M. Job, Catherine M.T. Sherwin

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 442 - 442

Published: March 21, 2025

Herbal and marine products in the form of extracts, infusions, decoctions have been used for centuries folk traditional medicine [...]

Language: Английский

Citations

0
Metabolomics fingerprinting uncovered regional and cultivation-specific metabolic signatures in panax notoginseng: insights into geographical and agricultural influences DOI
Zi Chen, Shijia Zhang, Zhiqiang Zhao

et al.

Journal of Food Composition and Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 107617 - 107617

Published: April 1, 2025

Language: Английский

Citations

0
A double network composite hydrogel with enhanced transdermal delivery by ultrasound for endometrial injury repair and fertility recovery DOI

Xin Zhang,

Shufang Wang, S. Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 50, P. 273 - 286

Published: April 14, 2025

Language: Английский

Citations

0
Panaxatriol exerts anti-senescence effects and alleviates osteoarthritis and cartilage repair fibrosis by targeting UFL1 DOI Creative Commons
Biao Kuang,

Nana Geng,

Yi Miao

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

1