A Selective Melatonin 2 Receptor Agonist, IIK7, Relieves Blue Light-Induced Corneal Damage by Modulating the Process of Autophagy and Apoptosis DOI Open Access
Ho Sung Yoon, Erhui Jiang, Jingting Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11243 - 11243

Published: Oct. 19, 2024

This study aims to investigate the effect of selective MT2 receptor agonist, IIK7, on corneal autophagy and apoptosis, aiming reduce epithelial damage inflammation from blue light exposure in mice. Eight-week-old C57BL/6 mice were divided into BL-exposed (BL) with IIK7 treatment (BL + group). Mice underwent (410 nm, 100 J) twice daily assessments at baseline days 3, 7, 14. Corneal samples analyzed for expression, markers (LC3-II p62), apoptosis indicators (BAX expression TUNEL assay). Then, assigned normal control, BL, BL IIK7. Ocular surface parameters, including fluorescein staining scores, tear volume, film break-up time, evaluated 7 On day 14, reactive oxygen species (ROS) levels CD4

Language: Английский

The role of melatonin and circadian rhythms in the pathogenesis of diabetic retinopathy: a systematic review DOI Creative Commons
Mallika Prem Senthil,

Eilish Devlin,

A. Hassani

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103202 - 103202

Published: Feb. 1, 2025

Language: Английский

Citations

1
The impact of circadian rhythms on retinal immunity DOI
He Ren,

Yilin Yuan,

Dong Zhang

et al.

Chronobiology International, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 15

Published: Feb. 7, 2025

The eye is an immune-protected organ, which driven by factors such as cytokines, chemicals, light, and mechanical stimuli. circadian clock intrinsic timing mechanism that influences the immune activities, cell count activity, well inflammatory responses. Recent studies have demonstrated also possesses rhythm, this rhythmic regulation participates in ocular modulation. In review, we discuss immunoregulatory mechanisms of within eye, reveal new perspectives for prevention treatment diseases.

Language: Английский

Citations

0
Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets DOI Creative Commons
Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu

et al.

Neurology International, Journal Year: 2025, Volume and Issue: 17(3), P. 42 - 42

Published: March 17, 2025

Background/Objectives: Blast-induced traumatic ocular injuries (bTOI) pose a significant risk to military and civilian populations, often leading visual impairment or blindness. Retina, the innermost layer of tissue consisting photoreceptor glial cells, is highly susceptible blast injuries. Despite its prevalence, molecular mechanisms underlying retinal damage following bTOI remain poorly understood, hindering development targeted therapies. Melatonin, neuroprotective indoleamine with antioxidant, anti-inflammatory, circadian regulatory properties, synthesized in retina plays crucial role health. Similarly, retina-specific genes, such as Rhodopsin, Melanopsin, RPE65, are essential for function, signaling, cycle. However, their responses exposure have not been thoroughly investigated. Methods: In this study, we utilized ferret model evaluate temporal expression melatonin-synthesizing enzymes, tryptophan hydroxylase 1 2 (TPH1 TPH2), Aralkylamine N-acetyltransferase (AANAT), Acetylserotonin-O-methyltransferase (ASMT), genes (Rhodopsin, Melanopsin) pigment epithelium-specific 65 kDa protein (RPE65) at 4 h, 24 7 days, 28 days post-blast. Ferrets were exposed tightly coupled overpressure waves using an advanced simulator, tissues collected quantitative polymerase chain reaction (qPCR) analysis. Results: The results revealed dynamic multiphasic transcriptional responses. TPH1 TPH2 exhibited upregulation followed by downregulation indicating blast-induced dysregulation metabolism, including melatonin synthesis. AANAT ASMT showed acute post-blast, late-phase disruptions. Rhodopsin increased h but declined while Melanopsin RPE65 demonstrated early downregulation, reflecting potential disruptions regulation Conclusions: These findings highlight complex bTOI, involving neuroinflammation, oxidative stress, synthesis cell functions. emphasize therapeutic mitigating preserving function.

Language: Английский

Citations

0
A Selective Melatonin 2 Receptor Agonist, IIK7, Relieves Blue Light-Induced Corneal Damage by Modulating the Process of Autophagy and Apoptosis DOI Open Access
Ho Sung Yoon, Erhui Jiang, Jingting Liu

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(20), P. 11243 - 11243

Published: Oct. 19, 2024

This study aims to investigate the effect of selective MT2 receptor agonist, IIK7, on corneal autophagy and apoptosis, aiming reduce epithelial damage inflammation from blue light exposure in mice. Eight-week-old C57BL/6 mice were divided into BL-exposed (BL) with IIK7 treatment (BL + group). Mice underwent (410 nm, 100 J) twice daily assessments at baseline days 3, 7, 14. Corneal samples analyzed for expression, markers (LC3-II p62), apoptosis indicators (BAX expression TUNEL assay). Then, assigned normal control, BL, BL IIK7. Ocular surface parameters, including fluorescein staining scores, tear volume, film break-up time, evaluated 7 On day 14, reactive oxygen species (ROS) levels CD4

Language: Английский

Citations

0