Identification of novel key genes and signaling pathways in hypertrophic cardiomyopathy: evidence from bioinformatics and next generation sequencing data analysis DOI Open Access
Basavaraj Vastrad, Chanabasayya Vastrad

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Hypertrophic cardiomyopathy (HCM) is a global health problem characterized by left ventricle become thick and stiff with effect of indication including chest pain, fluttering, fainting shortness breath. In this investigation, we aimed to identify diagnostic markers analyzed the therapeutic potential essential genes. Next generation sequencing (NGS) dataset GSE180313 was obtained from Gene Expression Omnibus (GEO) database used differentially expressed genes (DEGs) in HCM. DEGs were screened using DESeq2 Rbioconductor tool. Then, Ontology (GO) REACTOME pathway enrichment analyses performed. Moreover, protein-protein interaction (PPI) network constructed, module analysis Next, miRNA-hub gene regulatory TF-hub constructed analyzed. Finally, values hub assessed receiver operating characteristic (ROC) curve analysis. By performing analysis, total 958 (479 up regulated 479 down genes) successfully identified GSE180313, respectively. GO revealed that functions signaling pathways significantly enriched response stimulus, multicellular organismal process, metabolism extracellular matrix organization. The FN1, SOX2, TUBA4A, RPS2, TUBA1C, ESR1, SNCA, LCK, PAK1 APLNR might be associated gens FN1 TPM3, together corresponding predicted miRNAs (e.g., hsa-mir-374a-5p hsa-miR-8052), SH3KBP1 ESR1 TFs (e.g PRRX2 STAT3) found correlated This investigation could serve as basis for further understanding molecular pathogenesis targets

Language: Английский

Reconceptualizing Endothelial-to-mesenchymal transition in atherosclerosis: Signaling pathways and prospective targeting strategies DOI Creative Commons

Nanlin You,

Guohao Liu, Mengchen Yu

et al.

Journal of Advanced Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

The modification of endothelial cells (ECs) biological function under pathogenic conditions leads to the expression mesenchymal stromal (MSCs) markers, defined as endothelial-to-mesenchymal transition (EndMT). Invisible in onset and slow progression, atherosclerosis (AS) is a potential contributor various atherosclerotic cardiovascular diseases (ASCVD). By triggering AS, EndMT, "initiator" induces progression ASCVD such coronary heart disease (CHD) ischemic cerebrovascular (ICD), with serious clinical complications myocardial infarction (MI) stroke. In-depth research pathomechanisms EndMT identification targeted therapeutic strategies hold considerable value for prevention treatment ASCVD-associated delayed EndMT. Although previous studies have progressively unraveled complexity its pathogenicity triggered by alterations vascular microenvironmental factors, systematic descriptions most recent roles strategies, their future directions are scarce.

Language: Английский

Citations

2
Natural Products from Marine-Derived Fungi with Anti-Inflammatory Activity DOI Creative Commons

Yikang Qiu,

Shi-Ji Chen,

Miao Yu

et al.

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(10), P. 433 - 433

Published: Sept. 25, 2024

Inflammation is considered as one of the most primary protective innate immunity responses, closely related to body’s defense mechanism for responding chemical, biological infections, or physical injuries. Furthermore, prolonged inflammation undesirable, playing an important role in development various diseases, such heart disease, diabetes, Alzheimer’s atherosclerosis, rheumatoid arthritis, and even certain cancers. Marine-derived fungi represent promising sources structurally novel bioactive natural products, have been a focus research anti-inflammatory drugs. This review covers secondary metabolites with activities from marine-derived fungi, over period spanning August 2018 July 2024. A total 285 metabolites, including 156 compounds 11 skeleton structures, are described. Their structures categorized into five categories: terpenoids, polyketides, nitrogen-containing compounds, steroids, other classes. The targets, well vitro vivo screening models, were surveyed statistically summarized. paper aims offer valuable insights researchers exploration products discovery

Language: Английский

Citations

6
Polyphenol extract ameliorates diabetes-related atherosclerosis through HIF-1 signaling pathway in APOE−/- mice: possible synergism with atorvastatin DOI
Yang Yang,

Shengxiang Chen,

Gu Shi

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156572 - 156572

Published: Feb. 25, 2025

Language: Английский

Citations

0
Marine Natural Products in Inflammation‐Related Diseases: Opportunities and Challenges DOI

Tao Zhang,

Zijun Ouyang,

Yueran Zhang

et al.

Medicinal Research Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

ABSTRACT In recent decades, the potentiality of marine natural products (MNPs) in medical field has been increasingly recognized. Natural compounds derived from microorganisms, algae, and invertebrates have shown significant promise for treating inflammation‐related diseases. this review, we cover three primary sources MNPs their diverse unique chemical structures bioactivities. This review aims to summarize progress combating Moreover, functions mechanisms diseases, highlighting regulating inflammatory signaling pathways, cellular stress responses, gut microbiota, among others. Meanwhile, focus on key technologies scientific methods address current limitations challenges MNPs.

Language: Английский

Citations

0
Crosstalk between lipid metabolism and macrophages in atherosclerosis: therapeutic potential of natural products DOI Creative Commons

Taoming Qian,

Dong Guo, Lu Sun

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: March 3, 2025

Atherosclerosis is a highly prevalent cardiovascular condition that affects individuals worldwide. Despite ongoing research into its treatment and prevention, atherosclerotic disease continues to exhibit high morbidity mortality rates. The accumulation of low-density lipoprotein cholesterol considered major contributor the development atherosclerosis, with abnormalities in lipid metabolism playing significant role pathogenesis. Lipid macrophage function are intricately interconnected, being influenced by inflammatory responses, while activity regulated alterations metabolism. interaction between these two processes plays critical progression atherosclerosis. Natural products have shown considerable promise treating variety diseases, including Moreover, modulation crosstalk represents key mechanism through which natural may exert their effects. This aims provide new insights current state on regulating this pathway interplay macrophages context offering potential directions for future.

Language: Английский

Citations

0
Identification of novel key genes and signaling pathways in hypertrophic cardiomyopathy: evidence from bioinformatics and next generation sequencing data analysis DOI Open Access
Basavaraj Vastrad, Chanabasayya Vastrad

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract Hypertrophic cardiomyopathy (HCM) is a global health problem characterized by left ventricle become thick and stiff with effect of indication including chest pain, fluttering, fainting shortness breath. In this investigation, we aimed to identify diagnostic markers analyzed the therapeutic potential essential genes. Next generation sequencing (NGS) dataset GSE180313 was obtained from Gene Expression Omnibus (GEO) database used differentially expressed genes (DEGs) in HCM. DEGs were screened using DESeq2 Rbioconductor tool. Then, Ontology (GO) REACTOME pathway enrichment analyses performed. Moreover, protein-protein interaction (PPI) network constructed, module analysis Next, miRNA-hub gene regulatory TF-hub constructed analyzed. Finally, values hub assessed receiver operating characteristic (ROC) curve analysis. By performing analysis, total 958 (479 up regulated 479 down genes) successfully identified GSE180313, respectively. GO revealed that functions signaling pathways significantly enriched response stimulus, multicellular organismal process, metabolism extracellular matrix organization. The FN1, SOX2, TUBA4A, RPS2, TUBA1C, ESR1, SNCA, LCK, PAK1 APLNR might be associated gens FN1 TPM3, together corresponding predicted miRNAs (e.g., hsa-mir-374a-5p hsa-miR-8052), SH3KBP1 ESR1 TFs (e.g PRRX2 STAT3) found correlated This investigation could serve as basis for further understanding molecular pathogenesis targets

Language: Английский

Citations

0