Identifying the Involvement of Gut Microbiota in Retinal Vein Occlusion by Mendelian Randomization and Genetic Correlation Analysis

Translational Vision Science & Technology, Journal Year: 2025, Volume and Issue: 14(1), P. 5 - 5

Published: Jan. 9, 2025

Purpose: Previous researches have suggested an important association between gut microbiota (GM) and vascular pathologies such as atherosclerosis. This study aimed to explore the 196 GM taxa retinal vein occlusion (RVO). Methods: used Mendelian randomization (MR), linkage disequilibrium score regression (LDSC), polygenic overlap analysis. Genome-wide (GWAS) data associated with was obtained from MiBioGen consortium, involving a large number of European-ancestry participants. GWAS RVO FinnGen consortium another that also involved Inverse-variance weighted primary approach for MR estimation. Moreover, LDSC analyses were performed evaluate genetic correlation RVO. Results: The results identified six taxa, including class Bacilli, order Lactobacillales, family Streptococcaceae, genus Clostridium innocuum group, Family XIII AD3011 Subdoligranulum development In addition, analysis supported Conclusions: Our findings confirmed RVO, thereby highlighting effects on health. Translational Relevance: may provide rationale developing GM-based strategies preventing onset

Language: Английский

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Angiogenesis, a key point in the association of gut microbiota and its metabolites with disease

European journal of medical research, Journal Year: 2024, Volume and Issue: 29(1)

Published: Dec. 23, 2024

Abstract The gut microbiota is a complex and dynamic ecosystem that plays crucial role in human health disease, including obesity, diabetes, cardiovascular diseases, neurodegenerative inflammatory bowel cancer. Chronic inflammation common feature of these diseases closely related to angiogenesis (the process forming new blood vessels), which often dysregulated pathological conditions. Inflammation potentially acts as central mediator. This abstract aims elucidate the connection between various diseases. influences through mechanisms, production metabolites directly or indirectly affect vascularization. For example, short-chain fatty acids (SCFAs) such butyrate, propionate, acetate are known regulate immune responses inflammation, thereby affecting angiogenesis. In context promotes atherosclerosis vascular dysfunction by producing trimethylamine N-oxide (TMAO) other promote endothelial dysfunction. Similarly, may influence neuroinflammation integrity blood–brain barrier, cases fractures wound healing, activating effects, facilitating healing tissue damage. cancer, can either inhibit tumor growth angiogenesis, depending on specific bacterial composition their metabolites. instance, some bacteria activate inflammasomes, leading factors alter microenvironment angiogenesis-related signaling pathways, metastasis. Some interact with cells, pathways. Diet, modifiable factor, significantly diet-derived microbial Diet rapidly its metabolic activity, changing concentration microbial-derived profoundly host's response high animal protein diet pro-atherogenic like TMAO, pathways interfering platelet function, associated severity coronary artery plaques, peripheral A rich dietary fiber SCFAs, act ligands for cell surface intracellular receptors, regulating biological processes, homeostasis, responses, influencing summary, multifaceted, playing an important disease progression processes multiple Diet-derived play linking Understanding interactions diet, microbiota, has potential uncover novel therapeutic targets managing Therefore, interventions targeting metabolites, fecal transplantation (FMT) application probiotics enhance beneficial present promising strategy.

Language: Английский

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Endothelial dysfunction in chronic kidney disease: Mechanisms, biomarkers, diagnostics, and therapeutic strategies

Tzu Chi Medical Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

A BSTRACT Endothelial cells regulate vascular tone, blood flow, coagulation, and inflammation, with heterogeneous populations serving specific roles throughout the body. In kidney, endothelial maintain integrity function, contribute to filtration, support other renal structures. Nitric oxide (NO) is a key signaling molecule that maintains tone function. It synthesized by nitric synthase (NOS) isoforms, NOS playing central role in health. Chronic kidney disease (CKD) characterized reduced NO bioavailability, driven accumulation of endogenous inhibitors such as asymmetric dimethylarginine (ADMA) symmetric (SDMA). Uremic toxins, oxidative stress, proinflammatory cytokines prothrombotic state, contributing dysfunction exacerbating cardiovascular (CV) risks CKD. Biomarkers ADMA, SDMA, microparticles, soluble adhesion molecules offer insights into health, while invasive or noninvasive diagnostic techniques can assess function Effective management strategies focus on enhancing controlling reducing optimizing dialysis minimize uremic toxin levels. Emerging therapeutic approaches, including antioxidant therapies progenitor cell-based interventions, show promise preserving multifaceted approach managing critical for mitigating CV complications improving patient outcomes

Language: Английский

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Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas

Antioxidants, Journal Year: 2025, Volume and Issue: 14(5), P. 517 - 517

Published: April 25, 2025

Trimethylamine N-oxide (TMAO) is an endogenous osmolyte produced by enzymatic reactions starting in the human gut, where microbiota release trimethylamine (TMA) from foods, and ending liver, TMA oxidized to TMAO flavin-containing monooxygenase 3 (FMO3). While physiological concentrations of help proteins preserve their folding, high levels this metabolite are harmful promote oxidative stress, inflammation, atherosclerosis. In humans, elevated circulating predispose individuals cardiovascular diseases chronic kidney disease increase mortality risk, especially elderly. How exerts its negative effects has been only partially elucidated. hypertensive rats, eNOS substrate L-arginine Taurisolo®, a nutraceutical endowed with TMAO-reducing activity, act synergistically reduce arterial blood pressure. Here, we investigate molecular mechanisms underpinning synergism prove that TMAO, target acts as direct inhibitor endothelial nitric oxide synthase (eNOS) competes at catalytic site, ultimately inhibiting NO production acetylcholine (Ach)-induced relaxation murine aortas.

Language: Английский

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Gut-Vascular Axis and Postbiotics: The Need for Clear Definitions and Further Research

Pharmacological Research, Journal Year: 2024, Volume and Issue: 208, P. 107405 - 107405

Published: Sept. 11, 2024

Language: Английский

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Gut-Vascular Axis and Postbiotics: the Pharmacological Potential of Metabolites Encourages Broader Definitions

Pharmacological Research, Journal Year: 2024, Volume and Issue: unknown, P. 107416 - 107416

Published: Sept. 1, 2024

Language: Английский

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