International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 11281 - 11281
Published: Oct. 20, 2024
Systemic
lupus
erythematosus
(SLE)
is
a
chronic
autoimmune
disease
characterized
by
an
overproduction
of
cytokines,
such
as
interleukins
and
interferons,
contributing
to
systemic
inflammation
tissue
damage.
Antiphospholipid
syndrome
thrombo-inflammatory
affecting
third
SLE
patients.
We
performed
in-depth
analysis
the
available
literature,
we
highlighted
complex
interplay
between
immunity,
inflammation,
thrombosis,
three
major
pathogenic
pathways
that
are
trapped
in
mutually
reinforcing
destructive
loop.
Pharmacological Research,
Journal Year:
2025,
Volume and Issue:
212, P. 107574 - 107574
Published: Jan. 2, 2025
G
protein-coupled
receptors
(GPCRs)
represent
the
largest
family
of
membrane
and
are
highly
effective
targets
for
therapeutic
drugs.
GPCRs
couple
different
downstream
effectors,
including
proteins
(such
as
Gi/o,
Gs,
G12,
Gq)
β-arrestins
β-arrestin
1
2)
to
mediate
diverse
cellular
physiological
responses.
Biased
signaling
allows
specific
activation
certain
pathways
from
full
range
receptors'
capabilities.
Targeting
more
variable
allosteric
sites,
which
spatially
conserved
orthosteric
represents
a
novel
approach
in
biased
GPCR
drug
discovery,
leading
innovative
strategies
targeting
GPCRs.
Notably,
emergence
cryptic
sites
on
has
expanded
repertoire
available
improved
receptor
subtype
selectivity.
Here,
we
conduct
summary
recent
progress
structural
determination
elucidate
mechanisms
induced
by
modulators.
Additionally,
discuss
means
identify
design
modulators
based
through
structure-based
design,
is
an
advanced
pharmacotherapeutic
treating
GPCR-associated
diseases.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: Feb. 28, 2025
Neuroblastoma
(NB)
is
an
immunologically
“cold”
tumor
with
poor
or
no
inflamed
substrates
as
most
of
solid
pediatric
tumors
(SPT).
Consistent
data
indicate
that
NB
microenvironment
(TME)
dominated
by
myeloid
cells,
little
(but
variable)
T
cell
infiltration.
The
obstacles
to
lymphocyte
infiltration
and
their
anti-tumor
activity
are
due
different
immune
evasion
strategies,
including
loss
HLA
Class
I
molecules,
high
expression
checkpoint
molecular
ligands
leading
exhaustion
effector
(and
NK)
induction
regulatory,
stromal
cells
secretion
immunosuppressive
mediators.
In
odds
adult
tumors,
displays
weak
immunogenicity
caused
intrinsic
low
mutational
burden
scant
neoepitopes
in
the
context
MHC-class
antigens
which,
turn,
particularly
poorly
expressed
on
thus
inducing
responses.
addition,
generated
from
embryonal
result
transcriptional
abnormalities
not
accumulation
genetic
mutations
over
time,
further
explaining
immunogenicity.
immunogenic
molecules
associated
production
factors
which
downregulate
activity,
limited
efficacy
new
drugs
NB,
inhibitors.
This
review
focused
examining
role
regulatory
infiltrating
TME
taking
into
account
repertoire,
phenotype,
function,
plasticity
and,
importantly,
predictive
value
for
defining
novel
targets
therapy.
Exploration of Neuroprotective Therapy,
Journal Year:
2025,
Volume and Issue:
5
Published: March 9, 2025
Neurodegenerative
diseases
are
a
complex
ensemble
of
ailments
characterized
by
progressive
neuronal
deterioration
and
ultimate
loss,
resulting
in
drastic
impairments
memory,
cognition
other
brain
functions.
These
incapacitating
conditions
challenging
for
the
public
health
system
worldwide,
with
unfortunately
no
real
cure
lack
efficient
drugs
capable
delaying
or
reversing
these
diseases.
In
this
context,
endocannabinoid
exogenous
cannabinoids
represent
an
interesting
field
research
due
to
numerous
studies
highlighting
neuroprotective
effect
from
different
sources,
i.e.,
endogenous,
phytocannabinoids,
synthetic
cannabinoids.
This
review
highlights
multilayered
effects
block
progression
neurodegeneration
minimize
deleterious
insults
that
affect
brain.
We
illustrate
examples
showing
main
modulate
components
response
at
level
three
major
mechanisms
involved
neurodegeneration:
neuroinflammation,
excitotoxicity,
oxidative
stress.
Exploration of Neuroprotective Therapy,
Journal Year:
2025,
Volume and Issue:
5
Published: March 9, 2025
Neurodegenerative
diseases
are
a
complex
ensemble
of
ailments
characterized
by
progressive
neuronal
deterioration
and
ultimate
loss,
resulting
in
drastic
impairments
memory,
cognition
other
brain
functions.
These
incapacitating
conditions
challenging
for
the
public
health
system
worldwide,
with
unfortunately
no
real
cure
lack
efficient
drugs
capable
delaying
or
reversing
these
diseases.
In
this
context,
endocannabinoid
exogenous
cannabinoids
represent
an
interesting
field
research
due
to
numerous
studies
highlighting
neuroprotective
effect
from
different
sources,
i.e.,
endogenous,
phytocannabinoids,
synthetic
cannabinoids.
This
review
highlights
multilayered
effects
block
progression
neurodegeneration
minimize
deleterious
insults
that
affect
brain.
We
illustrate
examples
showing
main
modulate
components
response
at
level
three
major
mechanisms
involved
neurodegeneration:
neuroinflammation,
excitotoxicity,
oxidative
stress.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2025,
Volume and Issue:
13
Published: March 11, 2025
Bone
tissue
engineering
has
rapidly
emerged
as
an
ideal
strategy
to
replace
autologous
bone
grafts,
establishing
a
comprehensive
system
centered
on
biomaterial
scaffolds,
seeding
cells,
bioactive
factors,
and
biophysical
stimulation,
thus
paving
the
way
for
new
horizons
in
surgical
regeneration.
However,
scarcity
of
suitable
materials
poses
significant
challenge
replicating
intricate
multi-layered
structure
natural
tissue.
Supramolecular
peptide
nanofiber
hydrogels
(SPNHs)
have
shown
tremendous
potential
novel
biomaterials
due
their
excellent
biocompatibility,
biodegradability,
tunable
mechanical
properties,
multifunctionality.
Various
supramolecular
peptides
can
assemble
into
hydrogels,
while
sequences
factors
be
embedded
through
physical
adsorption
or
covalent
binding,
endowing
with
diverse
biochemical
properties.
Finally,
this
review
explored
future
challenges
prospects
SPNHs
engineering,
aim
providing
insights
further
advancements
field.
Small Methods,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
Abstract
Traditional
ophthalmic
formulations
are
characterized
by
low
bioavailability,
short
intraocular
retention
time,
strong
irritation,
and
failure
to
achieve
the
expected
therapeutic
effect
due
special
physiological
structure
of
eye
existence
many
barriers.
Microneedle
drug
delivery
is
a
novel
transdermal
modality.
Responsive
microneedles
defined
as
controllably
releasing
payloads
in
response
stimuli,
including
pH
levels,
temperature,
enzymes,
reactive
oxygen
species
(ROS),
well
external
stimuli
such
magnetic
fields
light.
In
addition
inheriting
advantages
traditional
microneedles,
which
include
enhanced
targeting
permeability,
non‐invasiveness,
painless
application,
integration
with
stimulus‐responsive
materials
enables
responsive
personalized
precision
process,
further
increases
accuracy
efficiency
ocular
treatments,
making
on‐demand
possible.
This
article
systematically
reviews
classification,
mechanisms,
characteristics
provides
detailed
introduction
their
diagnostic
applications
real‐time
monitoring
potential
diseases,
aiming
offer
insights
for
treatment
diseases
future.
Terapevticheskii arkhiv,
Journal Year:
2025,
Volume and Issue:
97(2), P. 157 - 162
Published: March 26, 2025
To
assess
the
muscle
mass
of
patients
with
inflammatory
bowel
disease
(IBD)
using
ultrasound.
102
IBD
hospitalized
in
gastroenterology
department
Republican
Clinical
Hospital
(Kazan)
were
involved
study.
Among
them,
49%
ulcerative
colitis,
51%
Crohn's
disease,
10
people
made
up
control
group
(CG).
The
median
age
was
39.5
[28.5;
50]
years,
CG
-
37
[26;
38]
years.
There
52
(51%)
women
and
5
(50%)
group.
Patients
examined
to
body
index
(BMI),
mid-upper
arm
circumference
(MUAC,
cm)
mid-thigh
(MTC,
dominant
side;
bioimpedance
analysis
composition
ABC-02
"MEDASS"
device;
ultrasound
examination
thickness
at
two
points
on
leading
side:
middle
shoulder
(US-MUAC),
thigh
(US-MTC),
dynamometry
a
wrist
dynamometer,
assessment
nutritional
status.
According
BMI,
distributed
as
follows:
normal
57
(55.9%)
patients;
deficiency
12
(11.8%);
overweight
25
(24.5%);
obesity
8
(7.8%).
Median
MUAC
28
[24.9;
31]
cm,
[27;
28.5]
cm
(p>0.05);
men
29.8
32]
33
[31;
34]
(p<0.05).
MTC
54.25
[48.15;
58.10]
61.5
[56;
67]
(p<0.05);
48
[46;
51.4]
GC
54
[53;
54]
US-MUAC
19.60
[18.23;
22.84]
mm,
22.49
[20.41;
22.66]
26.45
[22.87;
29.24]
21.54
[21.18;
25.13]
mm
(p>0.05).
US-MTC
31.05
[23.21;
37.11]
41.30
[35.55;
41.74]
(p<0.05),
30.90
[25.64;
39.99]
40.67
[39.10;
41.84]
results
bioimpedansometry,
skeletal
(SMI)
low
32%
patients,
65%,
above
3%.
correlated
(r=0.557;
p<0.05),
BMI
(r=0.448;
SMI
(r=0.666;
p<0.05).
(r=0.505;
(r=0.376;
(r=0.373;
In
IBD,
lower
than
CG.
CG,
which
MTC,
according
measurements
grip
strength
dynamometry.
Cancers,
Journal Year:
2025,
Volume and Issue:
17(7), P. 1205 - 1205
Published: April 1, 2025
The
complete
loss
of
S-methyl-5'-thioadenosine
phosphorylase
(MTAP)
expression,
often
due
to
homozygous
9p21
deletion,
creates
a
druggable
vulnerability
in
cancer
cells.
A
total
769
primary
pancreatic
ductal
adenocarcinomas
were
analyzed
on
tissue
microarrays
with
MTAP
immunohistochemistry
(IHC)
and
fluorescence
situ
hybridization
(FISH).
Intratumoral
heterogeneity
was
assessed
"heterogeneity"
TMA
containing
up
nine
samples
from
different
areas
236
tumor
nodal
metastases,
whole
sections
all
blocks
19
cancers.
expression
found
181
(37.9%)
478
interpretable
tumors
unrelated
pT,
pN,
grade,
size.
homogenous
37.6%
heterogeneous
1.1%
the
tumors,
at
least
three
evaluable
TMA.
On
sections,
1
showed
loss.
correlation
between
IHC
FISH
nearly
perfect,
98.8%
MTAP-deficient
showing
deletion.
is
frequent,
caused
by
mostly
homogeneous
adenocarcinomas.
Considering
also
their
aggressive
clinical
behavior,
may
represent
an
ideal
type
for
studying
new
drugs
targeting
cells
trials.
