Causal Exposures in Pancreatic Cancer Incidence: Insights From Mendelian Randomization Studies DOI Creative Commons
Ashraf Mohamadkhani, Reza Ghanbari,

Ramin Shakeri

et al.

JGH Open, Journal Year: 2025, Volume and Issue: 9(2)

Published: Feb. 1, 2025

ABSTRACT Aim Pancreatic cancer, marked by its high lethality and poor 5‐year survival rate, requires a thorough understanding of risk factors etiological mechanisms. In this review, we collected the latest findings from Mendelian randomization (MR) studies to identify potential causal for pancreatic cancer. Method Results The present analysis encompasses MR on gut oral microbiomes, non‐malignant phenotypes, blood metabolites, immune cells, chronic inflammation. Specific microbiome species have been identified as some with protective effects, others increasing risk. review also highlights associations between obesity, type 2 diabetes, well impact metabolites cell phenotypes disease Additionally, it investigates effects inflammatory bowel disease, showing significant increase associated Crohn's disease. Conclusion These insights emphasize need interdisciplinary research personalized medicine enhance prevention treatment strategies

Language: Английский

Causal Exposures in Pancreatic Cancer Incidence: Insights From Mendelian Randomization Studies DOI Creative Commons
Ashraf Mohamadkhani, Reza Ghanbari,

Ramin Shakeri

et al.

JGH Open, Journal Year: 2025, Volume and Issue: 9(2)

Published: Feb. 1, 2025

ABSTRACT Aim Pancreatic cancer, marked by its high lethality and poor 5‐year survival rate, requires a thorough understanding of risk factors etiological mechanisms. In this review, we collected the latest findings from Mendelian randomization (MR) studies to identify potential causal for pancreatic cancer. Method Results The present analysis encompasses MR on gut oral microbiomes, non‐malignant phenotypes, blood metabolites, immune cells, chronic inflammation. Specific microbiome species have been identified as some with protective effects, others increasing risk. review also highlights associations between obesity, type 2 diabetes, well impact metabolites cell phenotypes disease Additionally, it investigates effects inflammatory bowel disease, showing significant increase associated Crohn's disease. Conclusion These insights emphasize need interdisciplinary research personalized medicine enhance prevention treatment strategies

Language: Английский

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