Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications DOI Open Access

Asim J. Tashkandi,

Andrew Gorman,

Eva McGoldrick Mathers

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3016 - 3016

Published: March 26, 2025

The growing prevalence of diabetes highlights the urgent need to study diabetic cardiovascular complications, specifically cardiomyopathy, which is a diabetes-induced myocardial dysfunction independent hypertension or coronary artery disease. This review examines role mitochondrial in promoting cardiac and metabolic mechanisms such as hyperglycaemia-induced oxidative stress. Chronic hyperglycaemia insulin resistance can activate harmful pathways, including advanced glycation end-products (AGEs), protein kinase C (PKC) hexosamine signalling, uncontrolled reactive oxygen species (ROS) production mishandling Ca2+ transient. These processes lead cardiomyocyte apoptosis, fibrosis contractile dysfunction. Moreover, endoplasmic reticulum (ER) stress dysregulated RNA-binding proteins (RBPs) extracellular vesicles (EVs) contribute tissue damage, drives function towards heart failure (HF). Advanced patient-derived induced pluripotent stem cell (iPSC) organoids (iPS-COs) are transformative tools for modelling cardiomyopathy capturing human disease's genetic, epigenetic hallmarks. iPS-COs may facilitate precise examination molecular pathways therapeutic interventions. Future research directions encourage integration models with mechanistic techniques promote novel strategies.

Language: Английский

Efficacy of Microbiome-Targeted Interventions in Obesity Management- A comprehensive systematic review DOI
Dhivya Dhanasekaran, M. Venkatesan, Sarvesh Sabarathinam

et al.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2025, Volume and Issue: 19(2), P. 103208 - 103208

Published: Feb. 1, 2025

Language: Английский

Citations

3
Role of Mitochondrial Dysfunction in Neuropathy DOI Open Access
Nidia Espinoza, Vassilios Papadopoulos

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3195 - 3195

Published: March 29, 2025

Diabetes mellitus is characterized by a state of hyperglycemia, which can lead to severe complications if left untreated or poorly managed. Diabetic peripheral neuropathy (DPN) one common complication. This condition damage the nerves that supply legs and feet as well problems with blood vessels, heart, urinary tract. To alleviate pain for patients, clinicians resort long-term treatment regimens nerve medications, are usually either anticonvulsants antidepressants. However, little understood about underlying mechanisms DPN. Many pathogenic pathways have been proposed, mitochondrial dysfunction. Mitochondrial dysfunction includes range possible deficiencies given number functions controlled located in mitochondria, including their core function bioenergetics. review focuses on bioenergetics, respiration/ATP synthesis reactive oxygen species (ROS) production, calcium homeostasis apoptosis, potential targets effective diabetic neuropathy.

Language: Английский

Citations

1
Novel Polyethyleneimine-chitosan Nanoparticles Encapsulating Urolithin B: A Potential Nanotherapeutic Approach for Diabetic Nephropathy DOI

Jose Prakash Dharmian,

S. P. Angelin Claret,

P. Ramakrishnan

et al.

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 2, 2025

Language: Английский

Citations

0
Mitochondrial Dysfunction in Diabetes: Shedding Light on a Widespread Oversight DOI Creative Commons
Franklyn Nonso Iheagwam,

A B Joseph,

Eniola Deborah Adedoyin

et al.

Pathophysiology, Journal Year: 2025, Volume and Issue: 32(1), P. 9 - 9

Published: Feb. 13, 2025

Diabetes mellitus represents a complicated metabolic condition marked by ongoing hyperglycemia arising from impaired insulin secretion, inadequate action, or combination of both. Mitochondrial dysfunction has emerged as significant contributor to the aetiology diabetes, affecting various processes critical for glucose homeostasis. This review aims elucidate complex link between mitochondrial and covering spectrum diabetes types, role mitochondria in resistance, highlighting pathophysiological mechanisms, DNA damage, altered biogenesis dynamics. Additionally, it discusses clinical implications complications its complications, diagnostic approaches assessing function diabetics, therapeutic strategies, future directions, research opportunities.

Language: Английский

Citations

0
Metabolic and Mitochondrial Dysregulations in Diabetic Cardiac Complications DOI Open Access

Asim J. Tashkandi,

Andrew Gorman,

Eva McGoldrick Mathers

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 3016 - 3016

Published: March 26, 2025

The growing prevalence of diabetes highlights the urgent need to study diabetic cardiovascular complications, specifically cardiomyopathy, which is a diabetes-induced myocardial dysfunction independent hypertension or coronary artery disease. This review examines role mitochondrial in promoting cardiac and metabolic mechanisms such as hyperglycaemia-induced oxidative stress. Chronic hyperglycaemia insulin resistance can activate harmful pathways, including advanced glycation end-products (AGEs), protein kinase C (PKC) hexosamine signalling, uncontrolled reactive oxygen species (ROS) production mishandling Ca2+ transient. These processes lead cardiomyocyte apoptosis, fibrosis contractile dysfunction. Moreover, endoplasmic reticulum (ER) stress dysregulated RNA-binding proteins (RBPs) extracellular vesicles (EVs) contribute tissue damage, drives function towards heart failure (HF). Advanced patient-derived induced pluripotent stem cell (iPSC) organoids (iPS-COs) are transformative tools for modelling cardiomyopathy capturing human disease's genetic, epigenetic hallmarks. iPS-COs may facilitate precise examination molecular pathways therapeutic interventions. Future research directions encourage integration models with mechanistic techniques promote novel strategies.

Language: Английский

Citations

0