Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression DOI Creative Commons
Hongyi Zhao, Xiu Qiu, Shuyu Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

As a significant mental health disorder worldwide, the treatment of depression has long faced challenges low rate, drug side effects and high relapse rate. Recent studies have revealed that gut microbiota neuronal mitochondrial dysfunction play central roles in pathogenesis depression: influences course through multiple pathways, including immune regulation, HPA axis modulation neurotransmitter metabolism. Mitochondrial function serves as key hub mediates mood disorders mechanisms such defective energy metabolism, impaired neuroplasticity amplified neuroinflammation. Notably, bidirectional regulatory network exists between mitochondria: flora metabolite butyrate enhances biosynthesis activation AMPK–PGC1α pathway, whereas reactive oxygen species produced by mitochondria counteract composition altering intestinal epithelial microenvironment. In this study, we systematically potential pathways which improves regulating synthesis, autophagy, oxidative stress homeostasis proposed integration probiotic supplementation, dietary fiber intervention, fecal microbial transplantation to remodel flora–mitochondrial axis, provides theoretical basis for development novel antidepressant therapies targeting gut–brain interactions.

Language: Английский

Gut microbiota and atrial cardiomyopathy DOI Creative Commons

Tingting Sun,

Beibei Song, Bo Li

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: Feb. 4, 2025

Atrial cardiomyopathy is a multifaceted heart disease characterized by structural and functional abnormalities of the atria closely associated with atrial fibrillation its complications. Its etiology involves number factors, including genetic, infectious, immunologic, metabolic factors. Recent research has highlighted critical role gut microbiota in pathogenesis cardiomyopathy, this consistent gut–heart axis having major implications for cardiac health. The aim work to bridge knowledge gap regarding interactions between particular focus on elucidating mechanisms which dysbiosis may induce remodeling dysfunction. This article provides an overview changes composition effects metabolites. We also discuss how diet exercise affect influencing microbiota, as well possible future therapeutic approaches targeting axis. A healthy can prevent disease, but ecological lead variety symptoms, induction disease. pathophysiological aspects impact structure function, strategies exploring modulation treatment cardiomyopathy. Finally, we fecal transplantation oral probiotics or prebiotics. Our study highlights importance homeostasis cardiovascular health suggests that targeted interventions pave way innovative preventive

Language: Английский

Citations

0
Dietary phytosterol supplementation mitigates renal fibrosis via activating mitophagy and modulating the gut microbiota DOI Creative Commons
Fan Yang, Yingjie Gao,

Siyi Xie

et al.

Food & Function, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Chronic kidney disease (CKD) poses a significant global health challenge, primarily driven by renal fibrosis, with limited treatment options.

Language: Английский

Citations

0
The Functions of Major Gut Microbiota in Obesity and Type 2 Diabetes DOI Creative Commons

Siman Liu,

Zhipeng Tao, Mingyu Qiao

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 167 - 167

Published: March 1, 2025

Background: Gut microbiomes play a vital role in maintaining whole-body metabolic homeostasis. It has gained significant attention recent years due to advancements genome sequencing technologies and deeper understanding of its relationship with obesity. However, the specific ways which different microorganisms directly or indirectly influence host obesity, as well underlying mechanisms, remain uncertain because complexity gut microbiota composition. Methods: In this review, we summarize roles major phyla such Bacteroidetes, Firmicutes, Proteobacteria, Verrucomicrobia obesity type 2 diabetes based on studies published past five PubMed Google Scholar. The current therapeutic strategies associated are also explored from clinical trials, challenges future directions discussed. Results Conclusions: This review will provide functions diabetes, could lead more individualized effective treatments for diseases.

Language: Английский

Citations

0
Gerobiotics: Exploring the Potential and Limitations of Repurposing Probiotics in Addressing Aging Hallmarks and Chronic Diseases DOI
A.G.M.Sofi Uddin Mahamud,

Ishtiak Ahammed Tanvir,

Md. Ehsanul Kabir

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Language: Английский

Citations

0
Homocysteine Induced N6-Methyldeoxyadenosine Modification Perturbation Elicits Mitochondria Dysfunction Contributes to the Impairment of Learning and Memory Ability Caused by Early Life Stress in Rats DOI
Yun Zhao, Ling Zhang, Fang Xie

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Genetic variation in gut microbe as a key regulator of host social behavior in C. elegans DOI Creative Commons
Ying Li,

R. Kasturi Bai,

Yao Zhu

et al.

Gut Microbes, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 14, 2025

Gut microbiota have been shown to influence the social behaviors of their hosts, while variations in host genetics can affect composition microbiome. Nonetheless, degree which genetic microbial populations impact behavior, as well any potential transgenerational effects, remains inadequately understood. Utilizing C. elegans a model organism, we identified 77 strains E. coli from total 3,983 mutants that significantly enhanced aggregation behavior through various neurobehavioral pathways. This discovery underscores collaborative regulatory mechanism between and behavior. Notably, observed some mutant bacteria might via mitochondrial pathway. Additionally, modulation has heritable trait offspring. Our results provide novel perspective on role variation may significant implications for human studies development genetically engineered probiotics aimed at enhancing well-being across generations.

Language: Английский

Citations

0
Mitochondrial Dysfunction and Atherosclerosis: The Problem and the Search for Its Solution DOI Creative Commons
Ганна Володимирівна Невойт, Gediminas Jaruševičius, М. M. Potyazhenko

et al.

Biomedicines, Journal Year: 2025, Volume and Issue: 13(4), P. 963 - 963

Published: April 15, 2025

Background/Objectives: This review has been prepared to promote interest in the interdisciplinary study of mitochondrial dysfunction (MD) and atherosclerosis. aims describe state this problem indicate direction for further implementation knowledge clinical medicine. Methods: Extensive research literature was implemented elucidate role molecular mechanisms MD pathogenesis Results: A view on atherosclerosis through prism about is presented. cause primary mechanism onset progression It proposed that be considered context a continuum. Conclusions: are united by common pathogenesis. Knowledge should used argue healthy lifestyle as way prevent The development new approaches diagnosing treating an urgent task challenge modern science.

Language: Английский

Citations

0
Microbiome-based dietary supplements for better development and healthy brain DOI
Riddhi Upadhyay, Sugumar Mani, Murugan Sevanan

et al.

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0
Multiple pathways through which the gut microbiota regulates neuronal mitochondria constitute another possible direction for depression DOI Creative Commons
Hongyi Zhao, Xiu Qiu, Shuyu Wang

et al.

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

As a significant mental health disorder worldwide, the treatment of depression has long faced challenges low rate, drug side effects and high relapse rate. Recent studies have revealed that gut microbiota neuronal mitochondrial dysfunction play central roles in pathogenesis depression: influences course through multiple pathways, including immune regulation, HPA axis modulation neurotransmitter metabolism. Mitochondrial function serves as key hub mediates mood disorders mechanisms such defective energy metabolism, impaired neuroplasticity amplified neuroinflammation. Notably, bidirectional regulatory network exists between mitochondria: flora metabolite butyrate enhances biosynthesis activation AMPK–PGC1α pathway, whereas reactive oxygen species produced by mitochondria counteract composition altering intestinal epithelial microenvironment. In this study, we systematically potential pathways which improves regulating synthesis, autophagy, oxidative stress homeostasis proposed integration probiotic supplementation, dietary fiber intervention, fecal microbial transplantation to remodel flora–mitochondrial axis, provides theoretical basis for development novel antidepressant therapies targeting gut–brain interactions.

Language: Английский

Citations

0