Atorvastatin, simvastatin, rosuvastatin and Amyotrophic lateral sclerosis establishing cause and effect DOI
Min Li, Yaping Li, Xuping Yang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Abstract Background/Objectives: Statins are drugs that lower lipids levels, and widely used to reduce the risk of cardiovascular disease. Previous observational studies experimental investigations have indicated statin is associated with Amyotrophic Lateral Sclerosis (ALS). However, causal relationship remains unclear.The present study employs a two-sample Mendelian randomization (MR) analysis investigate between atorvastatin, simvastatin, rosuvastatin ALS at nenetic level. Methods: The utilized genome-wide association (GWAS) based on single-nucleotide polymorphisms (SNPs) for three statins (atorvastatin, rosuvastatin), encompassing data 462,933 participants obtained from UK Biobank, 80,610 individuals in genetic level European. investigation effects implemented five methods: inverse variance weighting (IVW), MR-Egger regression, wighted median, simple mode, weighted mode. To detect horizontal pleiotropy, intercept test MR pleiotropy residual sum outlier (MR-PRESSO) global were employed. Instrument heterogeneity was evaluated by Cochran’s Q statistics. Sensitivity performed via leave-one-out method. Results: suggest potential use ALS, odds ratio (OR) confidence interval (CI) providing further insight into strength this association. results estimate revealed significantly elevated atorvastatin (OR = 16.93, 95% CI: 5.42-52.89, p 1.13E-06), simvastatin 5.05, 2.92-8.75, 7.49E-09), 6.93E+5, 247.72-1.94E+9, 8.97-05). sensitivity highlighted stability reliability casual results. Conclusions: The provided evidence rosuvastatin) increased ALS. Given drug's effectiveness side effects, higher should be cautious about th statins. Further robust reserch needed confirm results, findings will provide valuable guidance drug patients.

Language: Английский

Expanding perspectives on the relationship between statin potency and lipophilicity in Alzheimer's disease management DOI Creative Commons
Yixiang Hu, Sen Peng,

Can Xiao

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107594 - 107594

Published: Jan. 10, 2025

Language: Английский

Citations

0
Response to letter to the editor: Expanding perspectives on the relationship between statin potency and lipophilicity in Alzheimer’s disease management DOI Creative Commons

Mar Garcia-Zamora,

Gemma García-Lluch,

Lucrecia Moreno

et al.

Pharmacological Research, Journal Year: 2025, Volume and Issue: 212, P. 107595 - 107595

Published: Jan. 9, 2025

Language: Английский

Citations

0
Atorvastatin, simvastatin, rosuvastatin and Amyotrophic lateral sclerosis establishing cause and effect DOI
Min Li, Yaping Li, Xuping Yang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Abstract Background/Objectives: Statins are drugs that lower lipids levels, and widely used to reduce the risk of cardiovascular disease. Previous observational studies experimental investigations have indicated statin is associated with Amyotrophic Lateral Sclerosis (ALS). However, causal relationship remains unclear.The present study employs a two-sample Mendelian randomization (MR) analysis investigate between atorvastatin, simvastatin, rosuvastatin ALS at nenetic level. Methods: The utilized genome-wide association (GWAS) based on single-nucleotide polymorphisms (SNPs) for three statins (atorvastatin, rosuvastatin), encompassing data 462,933 participants obtained from UK Biobank, 80,610 individuals in genetic level European. investigation effects implemented five methods: inverse variance weighting (IVW), MR-Egger regression, wighted median, simple mode, weighted mode. To detect horizontal pleiotropy, intercept test MR pleiotropy residual sum outlier (MR-PRESSO) global were employed. Instrument heterogeneity was evaluated by Cochran’s Q statistics. Sensitivity performed via leave-one-out method. Results: suggest potential use ALS, odds ratio (OR) confidence interval (CI) providing further insight into strength this association. results estimate revealed significantly elevated atorvastatin (OR = 16.93, 95% CI: 5.42-52.89, p 1.13E-06), simvastatin 5.05, 2.92-8.75, 7.49E-09), 6.93E+5, 247.72-1.94E+9, 8.97-05). sensitivity highlighted stability reliability casual results. Conclusions: The provided evidence rosuvastatin) increased ALS. Given drug's effectiveness side effects, higher should be cautious about th statins. Further robust reserch needed confirm results, findings will provide valuable guidance drug patients.

Language: Английский

Citations

0