Bone Adaptations to a Whole Body Vibration Protocol in Murine Models of Different Ages: A Preliminary Study on Structural Changes and Biomarker Evaluation

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 26 - 26

Published: Jan. 10, 2025

Background/Objectives: Whole body vibration (WBV) is a valuable tool to mitigate physiological adaptations related age and inactivity. Although significant benefits have been found at the musculoskeletal level, including increased bone mass reduced muscle atrophy, underlying biological mechanisms remain largely unknown. Therefore, our study aimed evaluate effects of vibratory training on tissue in murine models different groups by investigating structural distribution changes some crucial biomarkers involved homeostasis. Methods: Specifically, 4-, 12-, 24-month-old mice were trained with WBV protocol characterized three series 2 min 30 s, interspersed recovery period same duration, 3-weekly frequency for 3 months. At end training, histological morphometric analyses conducted, association immunohistochemical analysis investigate fibronectin type III domain-containing protein 5 (FNDC5), NADPH oxidase 4 (NOX4), sirtuin 1 (SIRT1). Results: Our preliminary results showed that improves health preserving architecture promoting up-regulation FNDC5 SIRT1 down-regulation NOX4. Conclusions: confirms as viable alternative counter decline elderly and/or sedentary subjects. Further investigations should be conducted deepen knowledge this field explore role other molecular mediators vibration.

Language: Английский

Irisin: muscle’s novel player in endoplasmic reticulum stress and disease

Molecular and Cellular Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

Language: Английский