Exosomes derived from natural killer cells: transforming immunotherapy for aggressive breast cancer

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 18, 2025

Language: Английский

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Enhancer zeste homolog 2 (EZH2) targeting by small interfering RNA (siRNA); recent advances and prospect

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Language: Английский

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Development and validation of an ARID1A-related immune genes risk model in evaluating prognosis and immune therapeutic efficacy for gastric cancer patients: a translational study

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Background Mutations in the ARID1A gene, an integral component of SWI/SNF complex, are prevalent, affecting prognosis and immune response several malignancies, including gastric cancer (GC). The aim this study was to identify mutation-associated genes construct ARID1A-related gene risk model (ARM). Methods GSEA ssGSEA were used explore involved biological pathways degree cell infiltration, respectively. constructed by lasso-COX. Protein expression level tissue verified immunohistochemistry. Small molecule compounds screened using molecular docking techniques their anticancer value validated vitro vivo experiment. Results This revealed immune-related infiltration multiple types enriched MUT group compared WT group. mutations correlated with improved individuals treated checkpoint inhibitor (ICI) analyzed via Cbioportal website. TCGA-STAD cohort randomly divided into a training-group testing-group. Additionally, ARM developed training group, which identified APOD PROC from differential immunity genes. A significantly poorer high-risk low-risk consistent across TCGA-training/testing/all cohorts, five GEO cohorts 55 GC patients Hainan General Hospital. Furthermore, microenvironment components ICI therapeutic efficacy markers different between two groups. Meanwhile, higher tissues para-cancerous tissues. Baicalin capsaicin inhibited proliferation metastatic ability cells. Conclusion provides valuable insights effectiveness ICI, thereby offering novel strategy for clinical decision. promising potential drugs treatment.

Language: Английский

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Mesenchymal stem cell derived exosomes as Nanodrug carrier of doxorubicin combined with PVT1 siRNA inhibits the progression of gastric cancer

Arab Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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